CAS Chem.name SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 108-44-1 3-Aminotoluene Cc1cccc(N)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 584-84-9 Toluene 2,4-diisocyanate Cc1ccc(cc1N=C=O)N=C=O negative negative in Vitro Mammalian Chromosome Aberration Test GULATI,DK. et al; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 55-80-1 3-Methyl-4'-(dimethylamino)azobenzene CN(C)c1ccc(cc1)N=Nc1cccc(C)c1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-59-2 2,3-Xylidine Cc1cccc(N)c1C negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 97-52-9 benzenamine, 2-methoxy-4-nitro- COc1cc(ccc1N)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-09-2 m-nitroaniline Nc1cccc(c1)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-68-8 4,4'-Diphenylmethane Diisocyanate O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 26630-87-5 Disperse Red 206 CC(=O)OCCN(CCOC(C)=O)c1ccc(N=Nc2nc3ccc(Cl)cc3s2)c(NC(=O)c2ccccc2)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 54-88-6 n,n-dimethyl-4-(phenylazo)-m-toluidine CN(C)c1ccc(N=Nc2ccccc2)c(C)c1 negative positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 91-23-6 o-nitroanizole COc1ccccc1[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 100-17-4 4-nitroanisole COc1ccc(cc1)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 570-24-1 1-amino-2-methyl-6-nitrobenzene Cc1cccc(c1N)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning 6-Nitro-O-Toluidine COLIPA N° B56 Adopted By The SCCNFP During The 24th Plenary Meeting Of 24-25 June 2003 54381-16-7 ethanol, 2,2'-o(4-aminophenyl)iminoabis-, sulfate (1:1) (salt) Nc1ccc(N(CCO)CCO)cc1_OS(O)(=O)=O negative positive in Vitro Mammalian Chromosome Aberration Test European Commission Health & Consumer Protection Directorate-GeneraL Directorate C - Public Health and Risk Assessment C7 - Risk assessment Scientific Committee On Consumer Products Opinion on N,N-bis(2-hydroxyethyl)-p-phenylenediamine sulfate COLIPA N° A50. Adopted by the SCCP during the 8th plenary meeting of 20 June 2006 136-40-3 Phenazopyridine hydrochloride Cl_Nc1ccc(/N=N/c2ccccc2)c(N)n1 negative positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 1936-15-8 c.i. acid orange 10 [Na+].[Na+].Oc1ccc2cc(cc(c2c1N=Nc1ccccc1)S([O-])(=O)=O)S([O-])(=O)=O negative positive in Vitro Mammalian Chromosome Aberration Test Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ. Mol. Mutagen., 1989, 14(3), 165-187. 34432-92-3 n-ethyl-n-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline CCN(CCOC(C)OCC(C)C)c1ccc(cc1)N=Nc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test N-Ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline, CAS No 34432-92-3. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/5682 51-28-5 2,4-Dinitro-phenol Oc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 90-04-0 o-Anisidine COc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-05-0 N,N-Diethyl-p-Phenylenediamine CCN(CC)c1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-68-5 butanamide,_n-(2-methylphenyl)-3-oxo- CC(=O)CC(=O)Nc1ccccc1C positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-54-5 o-Phenylenediamine Nc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-56-9 4-Nitro-o-Phenylenediamine Nc1ccc(cc1N)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-57-0 2-Amino-4-Nitrophenol Nc1cc(ccc1O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-98-9 N,N-Dimethyl-p-Phenylenediamine CN(C)c1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 100-22-1 N,N,N',N'-Tetramethyl-p-Phenylenediamine CN(C)c1ccc(cc1)N(C)C positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 100-61-8 Methyl-phenyl-amine CNc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 104-94-9 p-Anisidine COc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 106-50-3 p-Phenylenediamine Nc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-45-2 m-Phenylenediamine Nc1cccc(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 121-88-0 2-Amino-5-Nitrophenol Nc1ccc(cc1O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 123-30-8 4-Aminophenol Nc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 156-43-4 p-Phenetidine CCOc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 536-90-3 m-Anisidine COc1cccc(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 591-27-5 3-Aminophenol Nc1cccc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 5307-14-2 2-Nitro-p-Phenylenediamine Nc1ccc(N)c(c1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 15481-70-6 Toluene-2,6-diamine, dihydrochloride Cc1c(N)cccc1N_Cl_Cl positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 823-40-5 2,6-diaminotoluene Cc1c(N)cccc1N positive positive in Vitro Mammalian Chromosome Aberration Test ARMSTRONG,MJ, BEAN,CL AND GALLOWAY,SM; A QUANTITATIVE ASSESSMENT OF THE CYTOTOXICITY ASSOCIATED WITH CHROMOSOMAL ABERRATION DETECTION IN CHINESE HAMSTER OVARY CELLS; MUTAT. RES. 265(1):45-60, 1992 824-78-2 p-Nitrophenol sodium salt [Na+].[O-]c1ccc(cc1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 91-08-7 2,6-Toluene diisocyanate Cc1c(cccc1N=C=O)N=C=O positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK.et al; III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989; JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996 95-53-4 2-methylbenzenamine Cc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 91-97-4 Bitolylene diisocyanate Cc1cc(ccc1N=C=O)-c1ccc(N=C=O)c(C)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology Toxicology & Information Center, Japan (JETOC), Mutagenicity Test Data of Existing Chemical Substances, 1995/12/31; Test guideline equivalent or similar to OECD Guideline 473 (In vitro Mammalian Chromosome Aberration Test) and EU Method B.10 (Mutagenicity - In Vitro Mammalian Chromosome Aberration Test); http://apps.echa.europa.eu/registered/data/dossiers/DISS-9d9568c1-3c26-0b72-e044-00144f67d249/AGGR-6ce1eaf3-4cda-40c4-93ac-8c7f98960912_DISS-9d9568c1-3c26-0b72-e044-00144f67d249.html#GEN_RESULTS_HD 106-49-0 4-Aminotoluene; p-toluidine Cc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 16055-80-4 L-Kynurenine_sulfate NC{P-}(CC(=O)c1ccccc1N)C(O)=O_OS(O)(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 26381-41-9 Basic brown 16 [Cl-].C[N+](C)(C)c1ccc2ccc(O)c(N=Nc3ccc(N)cc3)c2c1 positive positive in Vitro Mammalian Chromosome Aberration Test OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS; CONCERNING BASIC BROWN 16COLIPA n° C9, adopted by the SCCNFP during the 23rd plenary meeting of 18 March 2003 95-80-7 Toluene-2,4-diamine Cc1ccc(N)cc1N positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; 95-70-5 2,5-diaminotoluene Cc1cc(N)ccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Products OPINION ON Toluene-2,5-diamine COLIPA n° A5 The SCCP adopted this opinion at its 13th plenary meeting on 2 October 2007 119-93-7 Orthotolidine Cc1cc(ccc1N)-c1ccc(N)c(C)c1 positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 20721-50-0 2,2'-((4-((4-Aminophenyl)azo)phenyl)imino)bisethanol Nc1ccc(cc1)N=Nc1ccc(cc1)N(CCO)CCO positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety OPINION ON Disperse Black 9 COLIPA n° C106 The SCCS adopted this opinion at its 6th plenary meeting of 23 March 2010 88-74-4 2-nitroaniline Nc1ccccc1[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL), 1997 100-01-6 4-nitroaniline Nc1ccc(cc1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 13552-44-8 Methylenedianiline dihydrochloride Cl_Cl_Nc1ccc(Cc2ccc(N)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(cc1)N=Nc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate, M. Jr, Harnois, M.C., Sofuni, T., A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 1988, 195(2), 151-213. 85-86-9 2-naphthalenol, 1- 4-(phenylazo)phenyl azo - Oc1ccc2ccccc2c1N=Nc1ccc(cc1)N=Nc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Au, W, Hsu, T.C., Studies on the clastogenic effects of biologic stains and dyes. Environ. Mutagen., 1979,1(1), 27-35. 6459-94-5 1,3-naphthalenedisulfonic acid, 8-[[3,3-dimethyl-4-[[4-[[(4-methylphenyl)sulfonyl]oxy]phenyl]azo][1,1-biphenyl]-4-yl]azo]-7-hydroxy-, disodium salt [Na+].[Na+].Cc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)\N=N\c1ccc(cc1C)-c1ccc(\N=N\c2c(O)ccc3cc(cc(c32)S([O-])(=O)=O)S([O-])(=O)=O)c(C)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1991, 405,1-236. 1937-37-7 direct black 38 [Na+].[Na+].Nc1ccc(N=Nc2ccc(cc2)-c2ccc(cc2)N=Nc2c(N)c3c(O)c(N=Nc4ccccc4)c(cc3cc2S([O-])(=O)=O)S([O-])(=O)=O)c(N)c1 negative negative in Vitro Mammalian Chromosome Aberration Test http://ntp.niehs.nih.gov/testing/status/agents/ts-10886-n.html#Genetic-Toxicology 39156-41-7 2,4-Diaminoanisole Sulfate COc1ccc(N)cc1N_OS(O)(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan