CAS Chem.name SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 87-61-6 1,2,3-Trichlorobenzene Clc1cccc(Cl)c1Cl negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 94-74-6 MCPA Cc1cc(Cl)ccc1OCC(O)=O negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 100-41-4 Ethyl Benzene CCc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-88-3 Toluene Cc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 26967-76-0 Tris(isopropylphenyl)phosphates CC(C)c1ccc(OP(=O)(Oc2ccc(cc2)C(C)C)Oc2ccc(cc2)C(C)C)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 89-83-8 5-methyl-2-(1-methylethyl)phenol; Thymol CC(C)c1ccc(C)cc1O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 92-52-4 Biphenyl c1ccc(cc1)-c1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 95-50-1 1,2-Dichlorobenzene Clc1ccccc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1570-64-5 4-Chloro-2-methyl-phenol Cc1cc(Cl)ccc1O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 26444-49-5 Diphenyl cresyl phosphate Cc1ccc(OP(=O)(Oc2ccccc2)Oc2ccccc2)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 611-19-8 benzene, 1-chloro-2-(chloromethyl)- ClCc1ccccc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 106-37-6 p-Dibromobenzene Brc1ccc(Br)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1918-16-7 propachlor CC(C)N(C(=O)CCl)c1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test UNITED STATES ENVIRONMENTAL PROTECTION AGENCY, Prevention, Pesticides And Toxic Substances (7508C), EPA 738-R-015, November 1998 90-41-5 2-aminobiphenyl (2-phenylaniline) Nc1ccccc1-c1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test http://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF90-41-5f.pdf 91-64-5 2h-1-benzopyran-2-one O=C1Oc2ccccc2C=C1 negative positive in Vitro Mammalian Chromosome Aberration Test Galloway, Sm., Armstrong, Mj., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, Bh., Resnick, Ma., Anderson, B. and Zeiger, E.; Chromosome Aberrations and Sister Chromatid Exchanges in Chinese Hamster Ovary Cells: Evaluations Of 108 Chemicals; Environ. Mol. Mutagen. 10(Suppl. 10):1-175, 1987 51630-58-1 Fenvalerate CC(C)C(C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1)c1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Caballo C., Herrara A., Barrueco C., Santa-Maria A., Sanz F., De La Plena E., Analysis Of Cytogenetic Damage Induced In CHO Cells By The Pyrethroid Insecticide Fenvalerate, Terato. Carcino. Mutagen., 1992, 12(6), 243-249 50-78-2 Acetylsalicylic Acid CC(=O)Oc1ccccc1C(O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 59-98-3 Tolazoline C1CN=C(Cc2ccccc2)N1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 65-45-2 Salicylamide NC(=O)c1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 90-02-8 salicylaldehyde Oc1ccccc1C=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 92-88-6 [1,1'-biphenyl]-4,4'-diol Oc1ccc(cc1)-c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 93-68-5 butanamide,_n-(2-methylphenyl)-3-oxo- CC(=O)CC(=O)Nc1ccccc1C positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-57-8 o-Chlorophenol Oc1ccccc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 97-53-0 1-Allyl-3-Methoxy-4-Hydroxybenzene COc1cc(CC=C)ccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 103-90-2 Acetaminophen CC(=O)Nc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-39-4 m-Cresol Cc1cccc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 118-79-6 2,4,6-Tribromophenol Oc1c(Br)cc(Br)cc1Br positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 458-37-7 Curcumin COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 637-07-0 Clofibrate CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 882-09-7 Colfibric_acid CC(C)(Oc1ccc(Cl)cc1)C(O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 938-73-8 ethenzamide;_Benzamide,_2-ethoxy-;_Benzamide,_o-ethoxy- CCOc1ccccc1C(N)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1129-41-5 3-Methylphenyl_N-methylcarbamate CNC(=O)Oc1cccc(C)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 2425-10-7 Phenol, 3,4-dimethyl-, methylcarbamate; Xylylcarb CNC(=O)Oc1ccc(C)c(C)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 58139-33-6 3,4-Dimethylphenyl-N-nitroso-N-methylcarbamate CN(N=O)C(=O)Oc1ccc(C)c(C)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 58139-35-8 3-Methylphenyl_N-nitroso_N-methylcarbamate CN(N=O)C(=O)Oc1cccc(C)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate Jr., M., and S. Odashima (1977) Mutation Res.,48, 337-354. 2416-94-6 2,3,6-trimethylphenol Cc1ccc(C)c(O)c1C positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 123-07-9 Phenol,_4-ethyl- CCc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 620-92-8 4,4'-Methylenebis(phenol) Oc1ccc(Cc2ccc(O)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 88-06-2 2,4,6-Trichlorophenol Oc1c(Cl)cc(Cl)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test WORLD HEALTH ORGANIZATION, INTERNATIONAL AGENCY FOR RESEARCH ON CANCER - IARC, MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide VOLUME 71, p.796-816 95-95-4 2,4,5-Trichlorophenol Oc1cc(Cl)c(Cl)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test Armstrong MJ, et. al., 2,4,6-Trichlorophenol (TCP) induces chromosome breakage and aneuploidy in vitro, Mutat Res,303(3),1993,101-108 98-54-4 p-tert-Butylphenol; Phenol, 4-(1,1-dimethylethyl)- CC(C)(C)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test p-tert-Butylphenol, CAS No 98-54-4,OECD SIDS Initial Assessment Report for 10th SIAM, Japan, march 15-17,2000 620-17-7 Phenol, 3-ethyl- CCc1cccc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test SCREENING-LEVEL HAZARD CHARACTERIZATION OF HIGH PRODUCTION VOLUME CHEMICALS, March, 2008, INTERIM 80-05-7 4,4'-Isopropylidenediphenol CC(C)(c1ccc(O)cc1)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tayama S., Nakagava Y., Tayama K., Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells, Mutat. Research649 (2008), 114-125Issues 1-2 89-72-5 O-sec-Butylphenol CCC(C)c1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test M.Matsumoto, et.al, Bull.Natl.Inst. health Sci., 2011,129, 68-75 106-48-9 p-Chlorophenol Oc1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS 120-83-2 2,4-Dichlorophenol Oc1ccc(Cl)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test HILLIARD,CA et al ; ENVIRON. MOL. MUTAGEN. 31(4):316-326, 1998 599-64-4 phenol,_4-(1-methyl-1-phenylethyl)- CC(C)(c1ccccc1)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Miller, J.E., Armstrong, M.J., Bean, C.L., Skopek, T.R., Nichols, W.W., DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens. Mutat. Res., 1998, 400(1-2), 169-186. 99-71-8 Phenol,_4-(1-methylpropyl)- CCC(C)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Kusakabe, H., Yamakage, K., Wakuri, S., Sasaki, K., Nakagawa, Y., Watanabe, M., Hayashi, M., Sofuni, T., Ono, H., Tanaka, N., Relevance of chemical structure and cytotoxicity to the induction of chromosome aberrations based on the testing results of 98 high production volume industrial chemicals. Mutat. Res., 2002, 517(1-2), 187-198. 69-72-7 2-hydroxybenzoic acid OC(=O)c1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 90-43-7 1,1'-biphenyl-2-ol Oc1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tayama-Nawai, S., Yoshida, S., Nakao, T., Hiraga, K., Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol. Mutat. Res., 1984, 141(2), 95-99. 132-27-4 O-Phenylphenate Sodium [Na+].[O-]c1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test ortho-PHENYLPHENOL AND ITS SODIUM SALT, IARC MONOGRAPHS VOLUME 73, p.451-480; Tayama, S. & Nakagawa, Y., Mutat. Res., 1991, 259, 1–12 933-75-5 2,3,6-trichlorophenol Oc1c(Cl)ccc(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test SOFUNI,T, et al; A COMPARISON OF CHROMOSOME ABERRATION INDUCTION BY 25 COMPOUNDS TESTED BY TWO CHINESE HAMSTER CELL (CHL AND CHO) SYSTEMS IN CULTURE; MUTAT. RES. 241(2), 1990, 175-213 1466-82-6 Aspirin anhydride CC(=O)Oc1ccccc1C(=O)OC(=O)c1ccccc1OC(C)=O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 15950-66-0 2,3,4-trichlorophenol Oc1ccc(Cl)c(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Sofuni, T., Shelby, M.D., Thilagar, A., Kumaroo, V., Kaur, P., Gulati, D., Putman, D.L., Murli, H., Marshall, R., Tanaka, N., Anderson, B., Zeiger, E., Ishidate, M. Jr, Multilaboratory comparison of in vitro tests for chromosome aberrations in CHO and CHL cells tested under the same protocols. Environ. Mol. Mutagen., 1997, 29(2), 189-207. 58-90-2 2,3,4,6-Tetrachlorophenol Oc1c(Cl)cc(Cl)c(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test WORLD HEALTH ORGANIZATION, INTERNATIONAL AGENCY FOR RESEARCH ON CANCER - IARC, MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide VOLUME 71, p.796-816 2185-92-4 2-Biphenylamine hydrochloride Cl_Nc1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193 106-44-5 p-cresol Cc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test p-Cresol, CAS No 106-44-5. ECHA Legal notice, Registration dossier. https://echa.europa.eu/registration-dossier/-/registered-dossier/15980 58-89-9 Lindane ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 912-60-7 Noscapine hydrochloride [Cl-].COc1ccc2[C@@H](OC(=O)c2c1OC)[C@@H]1[N+](C)CCc2cc3OCOc3c(OC)c12 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1333-16-0 Bisphenol F (mixed isomers) Oc1ccccc1Cc1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan