CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity	Bioassay - 	Reference(s) -
3234-02-4	Trans-2,3-Dibromo-2-Butene-1,4-Diol	OCC(Br)=C(Br)CO	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	P&G Inventory
75-35-4	1,1-Dichloroethylene	ClC(Cl)=C	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Strobel, K. and Grummt, T.; Aliphatic and Aromatic Halocarbons as Potential Mutagens an Drinking Water. III. Halogenated Ethanes and Ethenes; Toxicol. Environ. Chem. 15(1-2):101-128, 1987
127-18-4	Tetrachloroethylene	ClC(Cl)=C(Cl)Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Vamvakas, S. et. al.; mutagenicity of tetrachloroethene in the ames test-metabolic activation by conjugation with glutathione; J. Biochem. Toxicol. 4(1):21-27, 1989; Shimada, T.  et. al.; Activities of chlorinated ethane and ethylene compounds in the salmonella/rat microsome mutagenesis and rat hepatocyte/DNA repair assays under vapor phase exposure conditions; Cell Biol. Toxicol. 1(3):159-179, 1985
920-37-6	2-Chloroacrylonitrile	ClC(=C)C#N	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Eder, E., C. Deininger, E. Weinfurtner, Genotoxicity of 2-Halosubstituted Enals and 2-Chloroacrylonitrile in the Ames Test and the SOS Chromotest, Mutat. Res. 322 (1994), 321 – 328
2303-16-4	Diallate; Carbamic acid, diisopropylthio-, S-(2,3-dichloroallyl) ester	CC(C)N(C(C)C)C(=O)SCC(Cl)=CCl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	CCRIS database,Toxnet databases: Sandhu, SS et al.; Evaluation Of Diallate And Triallate Herbicides For Genotoxic Effects In A Battery Of In Vitro And Short-Term In Vivo Tests; Mutat. Res. 136(6):173-183, 1984
2303-17-5	Tri-allate	CC(C)N(C(C)C)C(=O)SCC(Cl)=C(Cl)Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	CCRIS database,Toxnet databases: De Lorenzo, F., Staiano, N., Silengo, L., Cortese, R., Mutagenicity of Diallate, Sulfallate, and Triallate and Relationship Between Structure and Mutagenic Effects of Carbamates Used Widely in Agriculture. Cancer Res., 1978, 38(1), 13 – 15
126-99-8	2-Cloro-1,3-butadiene; Chloroprene	ClC(=C)C=C	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	ECHA, Registration dossier: https://echa.europa.eu/registration-dossier/-/registered-dossier/15226/7/7/2; CCRIS database,Toxnet databases
79-27-6	1,1,2,2-Tetrabromoethane	BrC(Br)C(Br)Br	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Strubel, K., T. Grummt, Aliphatic and Aromatic Halocarbons as Potential Mutagens in Drinking Water. III. Halogenated Ethanes and Ethenes, Toxicol. Environ. Chem. 15(1-2) (1987), 101 – 128
62-73-7	Dichlorvos	COP(=O)(OC)OC=C(Cl)Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	P&G Inventory; U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
7166-19-0	beta-Bromo-beta-nitrostyrene	[O-][N+](=O)C(Br)=Cc1ccccc1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
87619-82-7	s-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine	NC(CSC(Cl)=C(Cl)C(Cl)=C(Cl)Cl)C(O)=O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Dekant, W, Vamvakas, S, Berthold, K, Schmidt, S, Wild, D And Henschler, D; Bacterial Beta-Lyase-Mediated Cleavage And Mutagenicity Of Cysteine Conjugates Derived From The Nephrocarcinogenic Alkenes Trichloroethylene, Tetrachloroethylene And Hexachlorobutadiene; Chem.-Biol. Interact. 60(1):31-45, 1986; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
98025-31-1	s-(1,2,2-trichlorovinyl)-l-cysteine	NC(CSC(Cl)=C(Cl)Cl)C(O)=O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Dekant, W, Vamvakas, S, Berthold, K, Schmidt, S, Wild, D And Henschler, D; Bacterial Beta-Lyase-Mediated Cleavage And Mutagenicity Of Cysteine Conjugates Derived From The Nephrocarcinogenic Alkenes Trichloroethylene, Tetrachloroethylene And Hexachlorobutadiene; Chem.-Biol. Interact. 60(1):31-45, 1986; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
111348-61-9	s-trichlorovinyl-n-acetylcysteine	CC(=O)NC(CSC(Cl)=C(Cl)Cl)C(O)=O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Vamvakas, S, Berthold, K, Dekant, W And Henschler, D; Bacterial Cysteine Conjugate Beta-Lyase And The Metabolism Of Cysteine S-Conjugates. Structural Requirements For The Cleavage Of S-Conjugates And The Formation Of Reactive Intermediates; Chem.-Biol. Interact. 65(1):59-71, 1988
766-40-5	3,4-dichloro-5-hydroxy-2(5h)-furanone;3,4-dichloro-5-hydroxyfuran-2(5h)-one	OC1OC(=O)C(Cl)=C1Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
31555-54-1	3,4-dichloro-5-dichloromethylene-2-furanone	ClC(Cl)=C1OC(=O)C(Cl)=C1Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Smeds, A, Franzen, R And Kronberg, L; Occurrence Of Some Chlorinated Enol Lactones And Cyclopentene-1,3-Diones In Chlorine-Treated Waters; Environ. Sci. Technol. 29(9):1839-1844, 1995; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
112654-68-9	3-chloro-5-dichloromethylene-2-furanone	ClC(Cl)=C1OC(=O)C(Cl)=C1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Smeds, A, Franzen, R And Kronberg, L; Occurrence Of Some Chlorinated Enol Lactones And Cyclopentene-1,3-Diones In Chlorine-Treated Waters; Environ. Sci. Technol. 29(9):1839-1844, 1995
149418-41-7	3,4-dibromo-2(5h)-furanone	BrC1COC(=O)C=1Br	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994
630-20-6	1,1,1,2-Tetrachloroethane	ClCC(Cl)(Cl)Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Strobel, K And Grummt, T; Aliphatic And Aromatic Halocarbons As Potential Mutagens In Drinking Water. Iii. Halogenated Ethanes And Ethenes; Toxicol. Environ. Chem. 15(1-2):101-128, 1987
79-01-6	Trichloroethylene	ClC=C(Cl)Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Strobel, K And Grummt, T; Aliphatic And Aromatic Halocarbons As Potential Mutagens In Drinking Water. III. Halogenated Ethanes And Ethenes; Toxicol. Environ. Chem. 15(1-2):101-128, 1987
87-68-3	Hexachloro-1,3-butadiene	ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25; Simmon, Vf; Structural Correlations Of Carcinogenic And Mutagenic Alkyl Halides; In: Asher, Im And Zervos,C (Eds.), Structural Correlates Of Carcinogenesis And Mutagenesis, A Guide To Testing Priorities, Proceedings Of The 2nd FDA Office Of Science Summer Symposium, August 31-September 2, 1977
6061-04-7	1,1-dichloro-2-nitroethene	[O-][N+](=O)C=C(Cl)Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
701909-41-3	2-chloroacrylic acid 3,3,4,4,5,5,6,6,6-nonafluorohexyl ester	FC(F)(F)C(F)(F)C(F)(F)C(F)(F)CCOC(=O)C(Cl)=C	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
*10008-27-5	3-chloro-1-(1-bromovinyl)benzene	Clc1cccc(c1)C(Br)=C	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
*10011-75-9	acetic acid 3-[2,6-dichloro-4-(3,3-dichloroallyloxy)phenoxy]propyl ester	CC(=O)OCCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
178043-48-6	3-[2,6-dichloro-4-(3,3-dichloroprop-2-enoxy)phenoxy]propan-1-ol	OCCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
6684-16-8	N-(2-chloro-3-phenyliminoprop-1-enyl)aniline hydrochloride	Cl_Cl/C(=C\Nc1ccccc1)/C=N/c1ccccc1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
179101-81-6	Pyridalyl	FC(F)(F)c1cccc(OCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)n1	in vitro Ames negative	Bacterial Reverse Mutation Assay (e.g. Ames Test)	United States Environmental Protection Agency (2009) Pyridalyl: Revised Human-Health Risk Assessment for Uses on Cotton, Fruiting Vegetables, Leafy Vegetables, Head & Stem Brassica Vegetables, Brassica Leafy Greens, and Turnip Greens, Shrubs, Ornamentals and Non-bearing Trees. https://www3.epa.gov/pesticides/chem_search/hhbp/R169200.pdf