CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity	Bioassay - 	Reference(s) -
50-18-0	Cyclophosphamide	ClCCN(CCCl)P1(=O)NCCCO1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240; P&G Inventory
17070-44-9	ICR 191	COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2c1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
51-75-2	Mechlorethamine	CN(CCCl)CCCl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
154-93-8	carmustine	ClCCNC(=O)N(CCCl)N=O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency, Mutation Research, 168 (1986) 69-240; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
17070-45-0	1,3-Propanediamine, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-, dihydrochloride	[Cl-].[Cl-].COc1ccc2nc3cc(Cl)ccc3c([NH+]CCC[NH+]CCCl)c2c1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency, Mutation Research, 168 (1986) 69-240; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
*6-00-1	ICR 180	COc1ccc2nccc(NCCCNCCCl)c2c1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-2	ICR 449	ClCCNCCCNc1c2ccccc2nc2ccccc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-3	ICR 174 (13441-95-7);	CCN(CCCl)CCCNc1ccnc2ccc(OC)cc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-4	ICR 445	CC1(C)c2nc3ccccc3c(NCCCNCCCl)c2C(C)(C)C(C)(C)C1(C)C	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-5	ICR 360	CCN(CCCl)CCCNc1c2ccccc2nc2c1C(C)(C)C(C)(C)C(C)(C)C2(C)C	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-6	ICR 411	COc1ccc2nc3ccccc3c(NCCNCCCl)c2c1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-7	ICR 376	COc1ccc2nc3ccccc3c(NCCCNCCCl)c2c1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-8	ICR 224	CCN(CCCl)CCCNc1c2ccccc2nc2ccc(OC)cc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-0	ICR 410	COc1cccc2c(NCCNCCCl)c3ccccc3nc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
92279-99-7	ICR 391	COc1cccc2c(NCCCNCCCl)c3ccccc3nc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
*6-01-1	ICR 377	CCN(CCCl)CCCNc1c2ccccc2nc2c(OC)cccc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-2	ICR 171	COc1ccc2nc3cc(Cl)ccc3c(NCCNCCCl)c2c1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-4	ICR 397	CCN(CCCl)CCOCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-5	ICR 364	COc1ccc2nc3cc(Cl)ccc3c(NCCNCCCl)c2n1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-6	ICR 372	COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2n1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-7	ICR 340	CCN(CCCl)CCCNc1c2ccc(Cl)cc2nc2ccc(OC)nc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-8	ICR 415	CCN(CCCl)CCOCCNc1c2ccc(Cl)cc2nc2ccc(OC)nc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-9	ICR 371	CCCCOc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2n1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-0	ICR 355	CCCCOc1ccc2nc3cc(Cl)ccc3c(NCCCN(CC)CCCl)c2n1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-1	ICR 370	ClCCNCCCNc1c2ccccc2nc2c3ccccc3ccc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-2	ICR 292	CCN(CCCl)CCCNc1c2ccccc2nc2c3ccccc3ccc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-3	ICR 395	ClCCNCCCNc1c2ccccc2nc2c1ccc1cccnc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-4	ICR 368	CCN(CCCl)CCCNc1c2ccccc2nc2c1ccc1cccnc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-5	ICR 455	ClCCNCCCNc1c2ccccc2nc2c3ccncc3ccc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
4213-45-0	Quinacrine mustard dihydrochloride	CC(CCCN(CCCl)CCCl)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12_Cl_Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency, Mutation Research, 168 (1986) 69-240; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
146-59-8	Acridine mustard (ICR 170)	CCN(CCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12)CCCl_Cl_Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-6	ICR 312	ClCCNCCNc1c2ccccc2nc2c3ccccc3ccc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
4465-94-5	Cytoxyl alcohol cyclohexylamine salt	NC1CCCCC1_OCCCNP(O)(=O)N(CCCl)CCCl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
38915-49-0	2-Ethanediamine, N-benz(c)acridin-7-yl-N'-(2-chloroethyl)-, dihydrochloride, hydrate; ICR 312	Cl_Cl_ClCCNCCNc1c2ccccc2nc2c1ccc1ccccc21_O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
38914-97-5	ICR 217	CCN(CCCNc1c2ccccc2nc2ccccc12)CCCl_Cl_Cl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
13909-09-6	Semustine; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea	CC1CCC(CC1)NC(=O)N(CCCl)N=O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	CCRIS database,Toxnet databases: Ashby, J, et. el.; Mutagenicity to Salmonella, Drosophila and the Mouse Bone Marrow of the Human Antineoplastic Agent Fotemustine: Prediction Of Carcinogenic Potency; Mutat. Res. 286(1):101- 109, 1993
92118-27-9	fotemustine	CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	CCRIS database,Toxnet databases: Ashby, J, et. el.; Mutagenicity to Salmonella, Drosophila and the Mouse Bone Marrow of the Human Antineoplastic Agent Fotemustine: Prediction Of Carcinogenic Potency; Mutat. Res. 286(1):101- 109, 1993
126-85-2	Nitrogen mustard N-oxide	C[N+]([O-])(CCCl)CCCl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	CCRIS database,Toxnet databases: Sakamoto, Y, et al; Triple Short-Term Tests With Bacteria And Drosophila For Assessment Of Mutagenicity Of Antineoplastics; Takeda Kenkyushoho 44(1/2):96-116, 1985
505-60-2	sulfur mustard	ClCCSCCCl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	CCRIS database,Toxnet databases: Stewart, D., Sass, E., Fritz, L., Sasser, L., Toxicology Studies on Lewisite and Sulfur Mustard Agents: Mutagenicity of Lewisite in the Salmonella Histidine Reversion Assay. U.S. Army Medical Research and Development Command, Ntis AD-A213102, 1989
*10009-32-8	N,N-bis(2-chloroethyl)-a-phenylbenzenemethanamine hydrochloride	Cl_ClCCN(CCCl)C(c1ccccc1)c1ccccc1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. Divizion of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html; Last update; June 2019
821-48-7	bis(2-chloroethyl)amine hydrochloride	Cl_ClCCNCCCl	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. Divizion of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html; Last update; June 2019