CAS Chem.name Chem.SMILES #Observed Mutagenicity Bioassay - Reference(s) - 96-18-4 1,2,3-Trichloropropane ClCC(Cl)CCl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G Inventory 3234-02-4 Trans-2,3-Dibromo-2-Butene-1,4-Diol OCC(Br)=C(Br)CO in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G Inventory 920-37-6 2-Chloroacrylonitrile ClC(=C)C#N in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Eder, E., C. Deininger, E. Weinfurtner, Genotoxicity of 2-Halosubstituted Enals and 2-Chloroacrylonitrile in the Ames Test and the SOS Chromotest, Mutat. Res. 322 (1994), 321 – 328 2303-16-4 Diallate; Carbamic acid, diisopropylthio-, S-(2,3-dichloroallyl) ester CC(C)N(C(C)C)C(=O)SCC(Cl)=CCl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) CCRIS database,Toxnet databases: Sandhu, SS et al.; Evaluation Of Diallate And Triallate Herbicides For Genotoxic Effects In A Battery Of In Vitro And Short-Term In Vivo Tests; Mutat. Res. 136(6):173-183, 1984 2303-17-5 Tri-allate CC(C)N(C(C)C)C(=O)SCC(Cl)=C(Cl)Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) CCRIS database,Toxnet databases: De Lorenzo, F., Staiano, N., Silengo, L., Cortese, R., Mutagenicity of Diallate, Sulfallate, and Triallate and Relationship Between Structure and Mutagenic Effects of Carbamates Used Widely in Agriculture. Cancer Res., 1978, 38(1), 13 – 15 78-87-5 1,2-Dichloro-propane CC(Cl)CCl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 542-75-6 1-Propene, 1,3-dichloro ClCC=CCl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 616-23-9 2,3-Dichloropropan-1-ol OCC(Cl)CCl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55965-84-9 Kathon 886 CN1C(=O)C=C(Cl)S1_CN1C(=O)C=CS1 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Connor, TH., Tee, PG., Afshar, M. and Connor, KM.; Mutagenicity of Cosmetic Products Containing Kathon; Environ. Mol. Mutagen. 28(2):127-132, 1996 87619-82-7 s-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine NC(CSC(Cl)=C(Cl)C(Cl)=C(Cl)Cl)C(O)=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Dekant, W, Vamvakas, S, Berthold, K, Schmidt, S, Wild, D And Henschler, D; Bacterial Beta-Lyase-Mediated Cleavage And Mutagenicity Of Cysteine Conjugates Derived From The Nephrocarcinogenic Alkenes Trichloroethylene, Tetrachloroethylene And Hexachlorobutadiene; Chem.-Biol. Interact. 60(1):31-45, 1986; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 115453-72-0 s-(1,2,3,3,3-pentachloroprop-1-enyl)-l-cysteine NC(CSC(Cl)=C(Cl)C(Cl)(Cl)Cl)C(O)=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Vamvakas, S, Berthold, K, Dekant, W And Henschler, D; Bacterial Cysteine Conjugate Beta-Lyase And The Metabolism Of Cysteine S-Conjugates. Structural Requirements For The Cleavage Of S-Conjugates And The Formation Of Reactive Intermediates; Chem.-Biol. Interact. 65(1):59-71, 1988 77439-76-0 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone;mx;3-chloro-4-dichloromethyl-5-hydroxy-2-furanone OC1OC(=O)C(Cl)=C1C(Cl)Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Meier, Jr, Blazak, Wf And Knohl, Rb; Mutagenic And Clastogenic Properties Of 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5h)-Furanone: A Potent Bacterial Mutagen In Drinking Water; Environ. Mol. Mutagen. 10:411-424, 1987; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 766-40-5 3,4-dichloro-5-hydroxy-2(5h)-furanone;3,4-dichloro-5-hydroxyfuran-2(5h)-one OC1OC(=O)C(Cl)=C1Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 112309-61-2 3-chloro-4-methyl-5-hydroxy-2(5h)-furanone;3-chloro-4-methyl-5-hydroxy-2(5h) furanone (mcf) CC1C(O)OC(=O)C=1Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 31555-54-1 3,4-dichloro-5-dichloromethylene-2-furanone ClC(Cl)=C1OC(=O)C(Cl)=C1Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Smeds, A, Franzen, R And Kronberg, L; Occurrence Of Some Chlorinated Enol Lactones And Cyclopentene-1,3-Diones In Chlorine-Treated Waters; Environ. Sci. Technol. 29(9):1839-1844, 1995; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 97055-38-4 3-chloro-4-(dichloromethyl)-5-methoxy-2(5h)-furanone COC1OC(=O)C(Cl)=C1C(Cl)Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ishiguro, Y, Lalonde, Rt, Dence, Cw And Santodonato ,J; Mutagenicity Of Chlorine-Substituted Furanones And Their Inactivation By Reaction With Nucleophiles;Environ. Toxicol. Chem; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 112654-68-9 3-chloro-5-dichloromethylene-2-furanone ClC(Cl)=C1OC(=O)C(Cl)=C1 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Smeds, A, Franzen, R And Kronberg, L; Occurrence Of Some Chlorinated Enol Lactones And Cyclopentene-1,3-Diones In Chlorine-Treated Waters; Environ. Sci. Technol. 29(9):1839-1844, 1995 122551-89-7 3-chloro-4-(dichloromethyl)-2(5h)-furanone;3-chloro-4-(dichloromethyl)-2-(5h)-furanone ClC(Cl)C1COC(=O)C=1Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 125974-01-8 3-chloro-4-(chloromethyl)-2(5h)-furanone ClCC1COC(=O)C=1Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 125974-08-5 3-chloro-4-(chloromethyl)-5-hydroxy-2(5h)-furanone OC1OC(=O)C(Cl)=C1CCl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 132059-51-9 3-chloro-4-(bromochloromethyl)-5-hydroxy-2(5h)-furanone OC1OC(=O)C(Cl)=C1C(Cl)Br in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Suzuki, N And Matsuo, T; Fractionation And Identification Of Mutagens In Chlorinated Tap Water; J. Fac. Eng. Univ. Tokyo, Ser.B 42(4):307-315, 1994 132059-52-0 3-chloro-4-(dibromomethyl)-5-hydroxy-2(5h)-furanone OC1OC(=O)C(Cl)=C1C(Br)Br in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Suzuki, N And Matsuo, T; Fractionation And Identification Of Mutagens In Chlorinated Tap Water; J. Fac. Eng. Univ. Tokyo, Ser.B 42(4):307-315, 1994 132059-53-1 3-bromo-4-(dibromomethyl)-5-hydroxy-2(5h)-furanone OC1OC(=O)C(Br)=C1C(Br)Br in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Suzuki, N And Matsuo, T; Fractionation And Identification Of Mutagens In Chlorinated Tap Water; J. Fac. Eng. Univ. Tokyo, Ser.B 42(4):307-315, 1994 149418-41-7 3,4-dibromo-2(5h)-furanone BrC1COC(=O)C=1Br in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 199536-62-4 3-bromo-4-(bromomethyl)-2(5h)-furanone BrCC1COC(=O)C=1Br in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 199536-64-6 3-bromo-4-(bromomethyl)-5-hydroxy-2(5h)-furanone OC1OC(=O)C(Br)=C1CBr in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 199536-65-7 3-chloro-4-(bromomethyl)-2(5h)-furanone ClC1C(=O)OCC=1CBr in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 199536-79-3 3-bromo-4-(dibromomethyl)-2(5h)-furanone BrC(Br)C1COC(=O)C=1Br in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 199536-82-8 3-chloro-4-(dibromomethyl)-2(5h)-furanone ClC1C(=O)OCC=1C(Br)Br in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 199536-84-0 3-bromo-4-(chloromethyl)-2(5h)-furanone ClCC1COC(=O)C=1Br in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lalonde, Rt And Leo, Hr; Interactive Chlorine-By-Bromine And Hydrogen-By-Hydroxyl Group Replacement Effects In 2(5h)-Furanone Mutagenicity; Chem. Res. Toxicol. 7(6):779-783, 1994 87-68-3 Hexachloro-1,3-butadiene ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25; Simmon, Vf; Structural Correlations Of Carcinogenic And Mutagenic Alkyl Halides; In: Asher, Im And Zervos,C (Eds.), Structural Correlates Of Carcinogenesis And Mutagenesis, A Guide To Testing Priorities, Proceedings Of The 2nd FDA Office Of Science Summer Symposium, August 31-September 2, 1977 13171-21-6 phosphamidon CCN(CC)C(=O)C(Cl)=C(C)OP(=O)(OC)OC in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) CCRIS database,Toxnet databases 21739-91-3 Cytembena [Na+].COc1ccc(cc1)C(=O)C(/Br)=C\C([O-])=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 14214-31-4 2-chloro-3-isothiocyanato-1-propene ClC(=C)CN=C=S in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. 178043-48-6 3-[2,6-dichloro-4-(3,3-dichloroprop-2-enoxy)phenoxy]propan-1-ol OCCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. 6684-16-8 N-(2-chloro-3-phenyliminoprop-1-enyl)aniline hydrochloride Cl_Cl/C(=C\Nc1ccccc1)/C=N/c1ccccc1 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. 701909-41-3 2-chloroacrylic acid 3,3,4,4,5,5,6,6,6-nonafluorohexyl ester FC(F)(F)C(F)(F)C(F)(F)C(F)(F)CCOC(=O)C(Cl)=C in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. 78-88-6 2,3-Dichloro-1-propene; 2,3-dichloropropene; 2,3-dichloropropene ClCC(Cl)=C in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. 179101-81-6 Pyridalyl FC(F)(F)c1cccc(OCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)n1 in vitro Ame negative United States Environmental Protection Agency (2009) Pyridalyl: Revised Human-Health Risk Assessment for Uses on Cotton, Fruiting Vegetables, Leafy Vegetables, Head & Stem Brassica Vegetables, Brassica Leafy Greens, and Turnip Greens, Shrubs, Ornamentals and Non-bearing Trees. https://www3.epa.gov/pesticides/chem_search/hhbp/R169200.pdf