CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity	Bioassay - 	Reference(s) -
4424-06-0	C.I. Pigment Orange 43	O=C1c2ccc3c4c2c(ccc4C(=O)N2C3=Nc3ccccc23)C2=Nc3ccccc3N12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
85721-33-1	Ciprofloxacin	OC(=O)C1=CN(C2CC2)c2cc(N3CCNCC3)c(F)cc2C1=O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Clerch, B., Barbe, J. and Llagostera, M.; The Role Of The Excision And Error-Prone Repair Systems In Mutagenesis By Fluorinated Quinolones In Salmonella Typhimurium; Mutat. Res. 281(3):207-213, 1992
98079-51-7	Lomefloxacin	CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	CCRIS database,Toxnet databases: Mamber, S.W., Kolek, B., Brookshire, K.W., Bonner, D.P., Fung-Tomc, J., Activity of Quinolones in the Ames Salmonella TA102 Mutagenicity Test and Other Bacterial Genotoxicity Assays. Antimicrob. Agents Chemother., 1993, 37(2), 213 – 217
389-08-2	1-ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid	CCN1C=C(C(O)=O)C(=O)c2ccc(C)nc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	CCRIS database,Toxnet databases: Heddle, J., A. Maxwell, Quinolone-Binding Pocket of DNA Gyrase: Role of GyrB, Antimicrob. Agents and Chemother. 46(6) (2002), 1805 – 1815
14698-29-4	oxolinic acid	CCN1C=C(C(O)=O)C(=O)c2cc3c(cc12)OCO3	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Mamber, S.W., Kolek, B., Brookshire, K.W., Bonner, D.P., Fung-Tomc, J., Activity of Quinolones in the Ames Salmonella TA102 Mutagenicity Test and Other Bacterial Genotoxicity Assays. Antimicrob. Agents Chemother., 1993, 37(2), 213 – 217
74011-58-8	1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid (Enoxacin)	CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCNCC3)nc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 Gyrase- and Four Mammalian Topoisomerase II-Poisons in Prokaryotic and Eukaryotic Test Systems, Mutagenesis 10(4) (1995), 343 – 351.
70458-96-7	1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (Norfloxacin)	CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCNCC3)cc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 Gyrase- and Four Mammalian Topoisomerase II-Poisons in Prokaryotic and Eukaryotic Test Systems, Mutagenesis 10(4) (1995), 343 – 351.
115550-35-1	Marbofloxacin	CN1CCN(c2c(F)cc3c4c2OCN(C)N4C=C(C(O)=O)C3=O)CC1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 Gyrase- and Four Mammalian Topoisomerase II-Poisons in Prokaryotic and Eukaryotic Test Systems, Mutagenesis 10(4) (1995), 343 – 351.
82419-36-1	Ofloxacin	CC1COc2c(N3CCN(C)CC3)c(F)cc3c2N1C=C(C(O)=O)C3=O	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 Gyrase- and Four Mammalian Topoisomerase II-Poisons in Prokaryotic and Eukaryotic Test Systems, Mutagenesis 10(4) (1995), 343 – 351.
103978-08-1	CP 67804; 1-Ethyl-6,8-difluoro-7-(4-hydroxyphenyl)-4-quinolone-3-carboxylic acid	CCN1C=C(C(O)=O)C(=O)c2cc(F)c(-c3ccc(O)cc3)c(F)c12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 Gyrase- and Four Mammalian Topoisomerase II-Poisons in Prokaryotic and Eukaryotic Test Systems, Mutagenesis 10(4) (1995), 343 – 351.
93106-60-6	Enrofloxacin	CCN1CCN(c2cc3c(cc2F)C(=O)C(C(O)=O)=CN3C2CC2)CC1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 Gyrase- and Four Mammalian Topoisomerase II-Poisons in Prokaryotic and Eukaryotic Test Systems, Mutagenesis 10(4) (1995), 343 – 351.
28657-80-9	Cinoxacin	CCN1c2cc3c(cc2C(=O)C(C(O)=O)=N1)OCO3	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 Gyrase- and Four Mammalian Topoisomerase II-Poisons in Prokaryotic and Eukaryotic Test Systems, Mutagenesis 10(4) (1995), 343 – 351.
70458-92-3	Pefloxacin	CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCN(C)CC3)cc12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 Gyrase- and Four Mammalian Topoisomerase II-Poisons in Prokaryotic and Eukaryotic Test Systems, Mutagenesis 10(4) (1995), 343 – 351.
23749-58-8	7H-benzimidazo[2,1-a]benz[de]isoquinolin-7-one	O=C1c2cccc3cccc(c23)C2=Nc3ccccc3N12	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
479-59-4	julolidine	C1CCc2cccc3CCCN1c23	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
88283-76-5	5-chloro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one	O=C1C(Cl)=Cc2cccc3CCN1c23	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.
913613-82-8	7-(4-chlorobutoxy)-1H-quinolin-2-one	O=C1C=Cc2ccc(OCCCCCl)cc2N1	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html.