CAS Chem.name Chem.SMILES #Observed Mutagenicity Bioassay - Reference(s) - 553-30-0 Proflavine sulfate Nc1ccc2cc3ccc(N)cc3nc2c1_OS(O)(=O)=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G Inventory 8048-52-0 Acriflavine Cn{+}1(.Cl{-})c2cc(N)ccc2cc2ccc(N)cc12_Nc1ccc2cc3ccc(N)cc3nc2c1 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) CCRIS database, Toxnet database: Brown, Jp. and Brown, Rj.; Mutagenesis by 9,10-Anthraquinone Derivatives and Related Compounds in Salmonella Typhimurium; Mutat. Res. 40:203-224, 1976 89459-25-6 n-[2-(dimethylamino)ethyl]-4-acridinecarboxamide;acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide CN(C)CCNC(=O)c1cccc2cc3ccccc3nc12 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 103554-58-1 n-[2-(dimethylamino)ethyl]-9,10-dihydro-9-oxo-4-acridinecarboxamide CN(C)CCNC(=O)c1cccc2c1Nc1ccccc1C2=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 103942-97-8 n-[2-(dimethylamino)ethyl]-1-phenazinecarboxamide CN(C)CCNC(=O)c1cccc2c1nc1ccccc1n2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 106626-55-5 n-[2-(dimethylamino)ethyl]-1-acridinecarboxamide;acridine-1-carboxylic acid (2-dimethylamino-ethyl)-amide CN(C)CCNC(=O)c1cccc2c1cc1ccccc1n2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 112022-07-8 n-[2-(dimethylamino)ethyl]-9-oxo-9h-thioxanthene-4-carboxamide CN(C)CCNC(=O)c1cccc2c1Sc1ccccc1C2=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 112022-08-9 n-[2-(dimethylamino)ethyl]-9-oxo-9h-xanthene-4-carboxamide CN(C)CCNC(=O)c1cccc2c1Oc1ccccc1C2=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 10048-13-2 Sterigmatocystin COc1cc2c(C3C=COC3O2)c2c1C(=O)c1c(cccc1O)O2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 479-50-5 lucanthone;miracild;1-{[2-(diethylamino)ethyl]amino}-4-methyl-9h-thioxanthen-9-one CCN(CC)CCNc1ccc(C)c2c1C(=O)c1ccccc1S2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Shubber, Ek, Jacobson-Kram, D And Williams, Jr; Comparison Of The Ames Assay And The Induction Of Sister Chromatid Exchanges: Results With Ten Pharmaceuticals And Five Selected Agents; Cell Biol. Toxicol. 2(3):379-399, 1986; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2798-25-6 bellidifolin COc1cc2c(c(O)c1)C(=O)c1c(O)ccc(O)c1O2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Matsushima, T, Araki, A, Yagame, O, Muramatsu, M, Koyama, K, Ohsawa, K, Natori, S And Tomimori, H; Mutagenicities Of Xanthone Derivatives In Salmonella Typhimurium Ta100, Ta98, Ta97, And Ta2637; Mutat. Res. 150(1-2):141-146, 1985; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2980-32-7 desmethylbellidifolin Oc1ccc(O)c2c1C(=O)c1c(cc(O)cc1O)O2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Matsushima, T, Araki, A, Yagame, O, Muramatsu, M, Koyama, K, Ohsawa, K, Natori, S And Tomimori, H; Mutagenicities Of Xanthone Derivatives In Salmonella Typhimurium TA100, TA98, TA97, And TA2637; Mutat. Res. 150(1-2):141-146, 1985; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 3722-54-1 1,3,7-trimethoxyxanthone COc1ccc2c(c1)C(=O)c1c(OC)cc(OC)cc1O2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Matsushima, T, Araki, A, Yagame, O, Muramatsu, M, Koyama, K, Ohsawa, K, Natori, S And Tomimori, H; Mutagenicities Of Xanthone Derivatives In Salmonella Typhimurium TA100, TA98, TA97, And TA2637; Mutat. Res. 150(1-2):141-146, 1985; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 5557-27-7 dimethylbellidifolin COc1ccc(O)c2c1Oc1cc(OC)cc(OC)c1C2=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Matsushima, T, Araki, A, Yagame, O, Muramatsu, M, Koyama, K, Ohsawa, K, Natori, S And Tomimori, H; Mutagenicities Of Xanthone Derivatives In Salmonella Typhimurium TA100, TA98, TA97, And TA2637; Mutat. Res. 150(1-2):141-146, 1985; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 17948-33-3 rutacridone CC(=C)C1Cc2c(cc(O)c3c2N(C)c2ccccc2C3=O)O1 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Paulini, H And Schimmer, O; Mutagenicity Testing Of Rutacridone Epoxide And Rutacridone, Alkaloids In Rutagraveolens L., Using The Salmonella/Microsome Assay; Mutagenesis 4(1):45-50, 1989; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-53-6 Austocystin d CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(c(O)c1C2=O)C1(O)C=COC1O3 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kfir, R, Johannsen, E And Vleggaar, R; Bull. Environ. Contam. Toxicol. 37(5):643650, 1986 55256-55-8 austocystin c CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(C4C=COC4O3)c(OC)c1C2=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kfir, R, Johannsen, E And Vleggaar, R; Mutagenic Activity Of Austocystins - Secondary Metabolites Of Aspergillus Ustus;Bull. Environ. Contam. Toxicol. 37(5):643-650, 1986; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-57-0 austocystin b CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(C4C=COC4O3)c(O)c1C2=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kfir, R, Johannsen, E And Vleggaar, R; Mutagenic Activity Of Austocystins - Secondary Metabolites Of Aspergillus Ustus;Bull. Environ. Contam. Toxicol. 37(5):643-650, 1986; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-58-1 Austocystin A COc1c(Cl)ccc2c1C(=O)c1c(cc3c(C4C=COC4O3)c1OC)O2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kfir, R, Johannsen, E And Vleggaar, R; Mutagenic Activity Of Austocystins - Secondary Metabolites Of Aspergillus Ustus;Bull. Environ. Contam. Toxicol. 37(5):643-650, 1986; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 58775-50-1 austocystin h CC(C)=CCc1ccc(O)c2c1Oc1cc3c(c(O)c1C2=O)C1(O)C=COC1O3 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kfir, R, Johannsen, E And Vleggaar, R; Mutagenic Activity Of Austocystins - Secondary Metabolites Of Aspergillus Ustus;Bull. Environ. Contam. Toxicol. 37(5):643-650, 1986 62512-94-1 isogravacridone chlorine CC(O)(CCl)C1Cc2c(cc(O)c3c2N(C)c2ccccc2C3=O)O1 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 77996-03-3 rutacridone epoxide CC1(C2Cc3c(cc(O)c4c3N(C)c3ccccc3C4=O)O2)CO1 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Paulini, H And Schimmer, O; Mutagenicity Testing Of Rutacridone Epoxide And Rutacridone, Alkaloids In Rutagraveolens L., Using The Salmonella/Microsome Assay; Mutagenesis 4(1):45-50, 1989; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 138154-39-9 5-((2-diethylamino)ethyl)amino)-8-hydroxy-6h-imidazo(4,5,1-de)acridin-6-one;c 1311 CCN(CC)CCNc1ccc2c3c1C(=O)c1cc(O)ccc1N3C=N2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Berger, B., Marquardt, H. and Westendorf, J.; Pharmacological and Toxicological Aspects of new Imidazoacridinone Antitumor Agents; Cancer Res. 56(9):2094-2104, 1996 138154-40-2 5-((2-(diethylamino)ethyl)amino)-8-hydroxy-1-methyl-6h-imidazo(4,5,1-de)acidin-6-one;c 1310 CCN(CC)CCNc1ccc2c3c1C(=O)c1cc(O)ccc1N3C(C)=N2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Berger, B., Marquardt, H. and Westendorf, J.; Pharmacological and Toxicological Aspects of new Imidazoacridinone Antitumor Agents; Cancer Res. 56(9):2094-2104, 1996 89458-99-1 n-[2-(dimethylamino)ethyl]-4-acridinecarboxamide, dihydrochloride Cl_Cl_CN(C)CCNC(=O)c1cccc2cc3ccccc3nc12 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Iwamoto, Y, Ferguson, Lr, Pearson, A And Baguley, B; Photoenhancement Of The Mutagenicity Of 9-Anilinoacridine Derivatives Related To The Antitumor Agent Amsacrine; Mutat. Res. 268(1):35-41, 1992; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 23255-93-8 Hycanthone methanesulfonate; Hycanthone mesylate CCN{+}(CC)(CCNc1ccc(CO)c2c1C(=O)c1ccccc1S2).O{-}S(C)(=O)=O in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G Inventory; Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 3105-97-3 Hycanthone CCN(CC)CCNc1ccc(CO)c2c1C(=O)c1ccccc1S2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 *10010-72-0 2-(acetyloxyiminomethyl)-9H-thioxanthene-9-one CC(=O)O/N=C/c1ccc2c(c1)C(=O)c1ccccc1S2 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. Divizion of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html; Last update; June 2019 *10012-90-9 3,7-bis(dimethylamino)-10H-phenothiazine-10-carboxylic acid triisopropylsilyl ester CC(C)[Si](C(C)C)(C(C)C)OC(=O)N1c2ccc(N(C)C)cc2Sc2cc(N(C)C)ccc12 in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. Divizion of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html; Last update; June 2019 116353-24-3 sodium 2-hydroxy-11H-benzo[a]carbazole-3-carboxylate Oc1cc2c(ccc3c2Nc2ccccc-32)cc1C(=O)O{-}.[Na]{+} in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Division of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html. Divizion of Genetic and Mutagenesis, National Institute of Health Science, Japan. ANEI-HOU, AMES/ QSAR International Collaborative Study; http://www.nihs.go.jp/dgm/amesqsar.html; Last update; June 2019