CAS Chem.name Chem.SMILES #Obs_CA_with_S9 Bioassay - Reference(s) - 106-47-8 p-Chloroaniline Nc1ccc(Cl)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-69-0 3,5-Xylidine Cc1cc(C)cc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 55-80-1 3-Methyl-4'-(dimethylamino)azobenzene Cc1cccc(N=Nc2ccc(N(C)C)cc2)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-59-2 2,3-Xylidine Cc1cccc(N)c1C in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-51-2 o-Chloroaniline Nc1ccccc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-09-2 m-nitroaniline Nc1cccc(N(=O)=O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 134-32-7 1-Naphthylamine Nc1cccc2ccccc12 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 554-00-7 2,4-Dichloroaniline Nc1ccc(Cl)cc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 54-88-6 n,n-dimethyl-4-(phenylazo)-m-toluidine Cc1cc(N(C)C)ccc1N=Nc1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 91-23-6 o-nitroanizole COc1ccccc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 100-17-4 4-nitroanisole COc1ccc(N(=O)=O)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 54381-16-7 ethanol, 2,2'-o(4-aminophenyl)iminoabis-, sulfate (1:1) (salt) Nc1ccc(N(CCO)CCO)cc1_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test European Commission Health & Consumer Protection Directorate-GeneraL Directorate C - Public Health and Risk Assessment C7 - Risk assessment Scientific Committee On Consumer Products Opinion on N,N-bis(2-hydroxyethyl)-p-phenylenediamine sulfate COLIPA N° A50. Adopted by the SCCP during the 8th plenary meeting of 20 June 2006 89-61-2 1,4-Dichloro-2-nitrobenzene O=N(=O)c1cc(Cl)ccc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 90-04-0 o-Anisidine COc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-05-0 N,N-Diethyl-p-Phenylenediamine CCN(CC)c1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-98-9 N,N-Dimethyl-p-Phenylenediamine CN(C)c1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 101-14-4 4,4'-Methylenebis(2-Chloroaniline) Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 104-94-9 p-Anisidine COc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-45-2 m-Phenylenediamine Nc1cccc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 156-43-4 p-Phenetidine CCOc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 536-90-3 m-Anisidine COc1cccc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1239-45-8 Homidium bromide CCn{+}1(.Br{-})c2cc(N)ccc2c2ccc(N)cc2c1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 3209-22-1 2,3-Dichloronitrobenzene O=N(=O)c1cccc(Cl)c1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 15481-70-6 Toluene-2,6-diamine, dihydrochloride Cc1c(N)cccc1N_Cl_Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 823-40-5 2,6-diaminotoluene Cc1c(N)cccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test ARMSTRONG,MJ, BEAN,CL AND GALLOWAY,SM; A QUANTITATIVE ASSESSMENT OF THE CYTOTOXICITY ASSOCIATED WITH CHROMOSOMAL ABERRATION DETECTION IN CHINESE HAMSTER OVARY CELLS; MUTAT. RES. 265(1):45-60, 1992 42397-64-8 1,6-Dinitropyrene O=N(=O)c1ccc2ccc3c(N(=O)=O)ccc4ccc1c2c34 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 42397-65-9 1,8-Dinitropyrene O=N(=O)c1ccc2ccc3ccc(N(=O)=O)c4ccc1c2c34 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 95-53-4 2-methylbenzenamine Cc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 106-49-0 4-Aminotoluene; p-toluidine Cc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 100-00-5 1-Chloro-4-nitrobenzene O=N(=O)c1ccc(Cl)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 5131-60-2 4-Chloro-m-phenylenediamine Nc1ccc(Cl)c(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996; Loveday, Ks., Anderson, Be., Resnick, Ma., Zeiger, E.; Chromosome Aberration And Sister Chromatid Exchange Tests In Chinese Hamster Ovary Cells In Vitro, V: Results With 46 Chemicals; Environ. Mol. Mutagen. 16(9):272-303, 1990 95-83-0 4-chloro-o-phenylenediamine Nc1ccc(Cl)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; 95-80-7 Toluene-2,4-diamine Cc1ccc(N)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; 95-70-5 2,5-diaminotoluene Cc1cc(N)ccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Products OPINION ON Toluene-2,5-diamine COLIPA n° A5 The SCCP adopted this opinion at its 13th plenary meeting on 2 October 2007 99-54-7 3,4-dichloronitrobenzene O=N(=O)c1ccc(Cl)c(Cl)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005 609-20-1 2,6-dichloro-p-phenylenediamine Nc1cc(Cl)c(N)c(Cl)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 119-93-7 Orthotolidine Cc1cc(-c2ccc(N)c(C)c2)ccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 20721-50-0 2,2'-((4-((4-Aminophenyl)azo)phenyl)imino)bisethanol Nc1ccc(N=Nc2ccc(N(CCO)CCO)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety OPINION ON Disperse Black 9 COLIPA n° C106 The SCCS adopted this opinion at its 6th plenary meeting of 23 March 2010 101-80-4 4,4'-oxydianiline Nc1ccc(Oc2ccc(N)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 137-17-7 2,4,5-trimethylaniline; trimethylaniline, 2,4,5-; 2,4,5trimethylaniline[1] Cc1cc(C)c(C)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test LOVEDAY,KS ANDERSON,BE RESNICK,MA ZEIGER,E; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO, V: RESULTS WITH 46 CHEMICALS; ENVIRON. MOL. MUTAGEN. 16(9):272-303, 1990 13552-44-8 Methylenedianiline dihydrochloride Cl_Cl_Nc1ccc(Cc2ccc(N)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 2185-92-4 2-Biphenylamine hydrochloride Cl_Nc1ccccc1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(N=Nc2ccccc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Ishidate, M. Jr, Harnois, M.C., Sofuni, T., A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 1988, 195(2), 151-213. 39156-41-7 2,4-Diaminoanisole Sulfate COc1ccc(N)cc1N_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 95-64-7 3,4-Xylidine Cc1ccc(N)cc1C in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 108-44-1 3-Aminotoluene Cc1cccc(N)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 611-06-3 2,4-Dichloronitrobenzene O=N(=O)c1ccc(Cl)cc1Cl in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-88-7 4-isopropylaniline;_p-Isopropylaniline CC(C)c1ccc(N)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 34432-92-3 n-ethyl-n-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline CCN(CCOC(C)OCC(C)C)c1ccc(N=Nc2ccccc2)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test N-Ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline, CAS No 34432-92-3. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/5682 90-41-5 2-aminobiphenyl (2-phenylaniline) Nc1ccccc1-c1ccccc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test http://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF90-41-5f.pdf