CAS Chem.name Chem.SMILES #Obs_CA_with_S9 Bioassay - Reference(s) - 106-47-8 p-Chloroaniline Nc1ccc(Cl)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 108-69-0 "3,5-Xylidine" Cc1cc(C)cc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 121-14-2 "2,4-Dinitrotoluene (purified)" Cc1ccc(N(=O)=O)cc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Sub., JETOC(Ed.) pp. 482 (1996)(Tables in English); http://www.j-ems.org/the-mutants/mo-ishidate/D-11.html" 55-80-1 3-Methyl-4'-(dimethylamino)azobenzene Cc1cccc(N=Nc2ccc(N(C)C)cc2)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 87-59-2 "2,3-Xylidine" Cc1cccc(N)c1C in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-51-2 o-Chloroaniline Nc1ccccc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 97-52-9 "benzenamine, 2-methoxy-4-nitro-" COc1cc(N(=O)=O)ccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-09-2 m-nitroaniline Nc1cccc(N(=O)=O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 134-32-7 1-Naphthylamine Nc1cccc2ccccc12 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 54-88-6 "n,n-dimethyl-4-(phenylazo)-m-toluidine" Cc1cc(N(C)C)ccc1N=Nc1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan." 91-23-6 o-nitroanizole COc1ccccc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996" 100-17-4 4-nitroanisole COc1ccc(N(=O)=O)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996" 570-24-1 1-amino-2-methyl-6-nitrobenzene Cc1cccc(N(=O)=O)c1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning 6-Nitro-O-Toluidine COLIPA N° B56 Adopted By The SCCNFP During The 24th Plenary Meeting Of 24-25 June 2003 54381-16-7 "ethanol, 2,2'-o(4-aminophenyl)iminoabis-, sulfate (1:1) (salt)" Nc1ccc(N(CCO)CCO)cc1_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "European Commission Health & Consumer Protection Directorate-GeneraL Directorate C - Public Health and Risk Assessment C7 - Risk assessment Scientific Committee On Consumer Products Opinion on N,N-bis(2-hydroxyethyl)-p-phenylenediamine sulfate COLIPA N° A50. Adopted by the SCCP during the 8th plenary meeting of 20 June 2006" 53-96-3 2-Acetylaminofluorene CC(=O)Nc1ccc2c(Cc3ccccc-23)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Matsuoka, A., M. Hayashi and M. Ishidate Jr. (1979), Mutation Res., 66, 277-290" 90-04-0 o-Anisidine COc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 93-05-0 "N,N-Diethyl-p-Phenylenediamine" CCN(CC)c1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 95-54-5 o-Phenylenediamine Nc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 97-00-7 "2,4-Dinitrochlorobenzene" O=N(=O)c1ccc(Cl)c(N(=O)=O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 99-56-9 4-Nitro-o-Phenylenediamine Nc1ccc(N(=O)=O)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 99-98-9 "N,N-Dimethyl-p-Phenylenediamine" CN(C)c1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 100-22-1 "N,N,N',N'-Tetramethyl-p-Phenylenediamine" CN(C)c1ccc(N(C)C)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 101-14-4 "4,4'-Methylenebis(2-Chloroaniline)" Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 104-94-9 p-Anisidine COc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 108-45-2 m-Phenylenediamine Nc1cccc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 156-43-4 p-Phenetidine CCOc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 536-90-3 m-Anisidine COc1cccc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1239-45-8 Homidium bromide CCn{+}1(.Br{-})c2cc(N)ccc2c2ccc(N)cc2c1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 15481-70-6 "Toluene-2,6-diamine, dihydrochloride" Cc1c(N)cccc1N_Cl_Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 823-40-5 "2,6-diaminotoluene" Cc1c(N)cccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "ARMSTRONG,MJ, BEAN,CL AND GALLOWAY,SM; A QUANTITATIVE ASSESSMENT OF THE CYTOTOXICITY ASSOCIATED WITH CHROMOSOMAL ABERRATION DETECTION IN CHINESE HAMSTER OVARY CELLS; MUTAT. RES. 265(1):45-60, 1992" 42397-64-8 "1,6-Dinitropyrene" O=N(=O)c1ccc2ccc3c(N(=O)=O)ccc4ccc1c2c34 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 42397-65-9 "1,8-Dinitropyrene" O=N(=O)c1ccc2ccc3ccc(N(=O)=O)c4ccc1c2c34 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 95-53-4 2-methylbenzenamine Cc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213." 60-27-5 "4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; Creatinine" CN1CC(=O)NC1=N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan." 7532-20-9 "1,3-Dinitropyrene" O=N(=O)c1cc(N(=O)=O)c2ccc3cccc4ccc1c2c34 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan." 67730-11-4 "2-amino-6-methyldipyrido(1,2-a:3',2'-d)imidazole; GLU-P-1" CC1=CC=CN2C1=Nc1ccc(N)nc21 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan." 154-42-7 "6-Thioguanine; 2-Amino-1,7-dihydro-6H-purin-6-thion" NC1NC(=S)C2=C(NC=N2)N=1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Yajima N., et al., Mutation Res., 88, 241-254, 1981." 106-49-0 4-Aminotoluene; p-toluidine Cc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213." 127-07-1 Hydroxyurea NC(=O)NO in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Borenfreund E., Krim M., Bendich A., Chromosomal aberrations induced by hyponitrile and hydroxylamine derivatives, J. Natl. Cancer Inst., 1964, 32(3), 667-679." 6098-44-8 n-acetoxy-2-acetylaminofluorene CC(=O)N(c1ccc2c(Cc3ccccc-23)c1)OC(C)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Tates AD & Kriek E: Mutation Res., 88, 397-410 (1981)" 117-79-3 2-Aminoanthraquinone Nc1ccc2c(c1)C(=O)c1ccccc1C2=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996" 100-00-5 1-Chloro-4-nitrobenzene O=N(=O)c1ccc(Cl)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996" 5131-60-2 4-Chloro-m-phenylenediamine Nc1ccc(Cl)c(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996; Loveday, Ks., Anderson, Be., Resnick, Ma., Zeiger, E.; Chromosome Aberration And Sister Chromatid Exchange Tests In Chinese Hamster Ovary Cells In Vitro, V: Results With 46 Chemicals; Environ. Mol. Mutagen. 16(9):272-303, 1990" 95-83-0 4-chloro-o-phenylenediamine Nc1ccc(Cl)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; " 95-80-7 "Toluene-2,4-diamine" Cc1ccc(N)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; " 95-70-5 "2,5-diaminotoluene" Cc1cc(N)ccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Scientific Committee on Consumer Products OPINION ON Toluene-2,5-diamine COLIPA n° A5 The SCCP adopted this opinion at its 13th plenary meeting on 2 October 2007" 119-93-7 Orthotolidine Cc1cc(-c2ccc(N)c(C)c2)ccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987" 20721-50-0 "2,2'-((4-((4-Aminophenyl)azo)phenyl)imino)bisethanol" Nc1ccc(N=Nc2ccc(N(CCO)CCO)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety OPINION ON Disperse Black 9 COLIPA n° C106 The SCCS adopted this opinion at its 6th plenary meeting of 23 March 2010 88-74-4 2-nitroaniline Nc1ccccc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL), 1997" 100-01-6 4-nitroaniline Nc1ccc(N(=O)=O)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987" 101-80-4 "4,4'-oxydianiline" Nc1ccc(Oc2ccc(N)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989" 137-17-7 "2,4,5-trimethylaniline; trimethylaniline, 2,4,5-; 2,4,5trimethylaniline[1]" Cc1cc(C)c(C)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "LOVEDAY,KS ANDERSON,BE RESNICK,MA ZEIGER,E; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO, V: RESULTS WITH 46 CHEMICALS; ENVIRON. MOL. MUTAGEN. 16(9):272-303, 1990" 13552-44-8 Methylenedianiline dihydrochloride Cl_Cl_Nc1ccc(Cc2ccc(N)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989" 2185-92-4 2-Biphenylamine hydrochloride Cl_Nc1ccccc1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193" 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(N=Nc2ccccc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate, M. Jr, Harnois, M.C., Sofuni, T., A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 1988, 195(2), 151-213." 39156-41-7 "2,4-Diaminoanisole Sulfate" COc1ccc(N)cc1N_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 56-57-5 4-Nitroquinoline-N-oxide O=n1ccc(N(=O)=O)c2ccccc12 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate Jr., M., and S. Odashima (1977) Mutation Res.,48, 337-354" 95-64-7 "3,4-Xylidine" Cc1ccc(N)cc1C in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 97-56-3 C.I. Solvent Yellow 3 Cc1ccccc1N=Nc1ccc(N)c(C)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 108-44-1 3-Aminotoluene Cc1cccc(N)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-88-7 4-isopropylaniline;_p-Isopropylaniline CC(C)c1ccc(N)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 6459-94-5 "1,3-naphthalenedisulfonic acid, 8-[[3,3-dimethyl-4-[[4-[[(4-methylphenyl)sulfonyl]oxy]phenyl]azo][1,1-biphenyl]-4-yl]azo]-7-hydroxy-, disodium salt" Cc1ccc(S(=O)(=O)Oc2ccc(/N=N/c3ccc(-c4ccc(/N=N/c5c(O)ccc6cc(S(=O)(=O)O{-}.[Na]{+})cc(S(=O)(=O)O{-}.[Na]{+})c56)c(C)c4)cc3C)cc2)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "NTP Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1991, 405,1-236." 1937-37-7 direct black 38 Nc1ccc(N=Nc2ccc(-c3ccc(N=Nc4c(S(=O)(=O)O{-}.[Na]{+})cc5cc(S(=O)(=O)O{-}.[Na]{+})c(N=Nc6ccccc6)c(O)c5c4N)cc3)cc2)c(N)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test http://ntp.niehs.nih.gov/testing/status/agents/ts-10886-n.html#Genetic-Toxicology 34432-92-3 n-ethyl-n-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline CCN(CCOC(C)OCC(C)C)c1ccc(N=Nc2ccccc2)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "N-Ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline, CAS No 34432-92-3. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/5682" 90-41-5 2-aminobiphenyl (2-phenylaniline) Nc1ccccc1-c1ccccc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test http://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF90-41-5f.pdf