CAS Chem.name Chem.SMILES #Obs_CA_with_S9 Bioassay - Reference(s) - 106-47-8 p-Chloroaniline Nc1ccc(Cl)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 55-80-1 3-Methyl-4'-(dimethylamino)azobenzene Cc1cccc(N=Nc2ccc(N(C)C)cc2)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 87-59-2 "2,3-Xylidine" Cc1cccc(N)c1C in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-09-2 m-nitroaniline Nc1cccc(N(=O)=O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 54-88-6 "n,n-dimethyl-4-(phenylazo)-m-toluidine" Cc1cc(N(C)C)ccc1N=Nc1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan." 570-24-1 1-amino-2-methyl-6-nitrobenzene Cc1cccc(N(=O)=O)c1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning 6-Nitro-O-Toluidine COLIPA N° B56 Adopted By The SCCNFP During The 24th Plenary Meeting Of 24-25 June 2003 54381-16-7 "ethanol, 2,2'-o(4-aminophenyl)iminoabis-, sulfate (1:1) (salt)" Nc1ccc(N(CCO)CCO)cc1_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "European Commission Health & Consumer Protection Directorate-GeneraL Directorate C - Public Health and Risk Assessment C7 - Risk assessment Scientific Committee On Consumer Products Opinion on N,N-bis(2-hydroxyethyl)-p-phenylenediamine sulfate COLIPA N° A50. Adopted by the SCCP during the 8th plenary meeting of 20 June 2006" 51-28-5 "2,4-Dinitro-phenol" Oc1ccc(N(=O)=O)cc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 93-05-0 "N,N-Diethyl-p-Phenylenediamine" CCN(CC)c1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 95-54-5 o-Phenylenediamine Nc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 97-00-7 "2,4-Dinitrochlorobenzene" O=N(=O)c1ccc(Cl)c(N(=O)=O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 99-56-9 4-Nitro-o-Phenylenediamine Nc1ccc(N(=O)=O)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 99-57-0 2-Amino-4-Nitrophenol Nc1cc(N(=O)=O)ccc1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 99-98-9 "N,N-Dimethyl-p-Phenylenediamine" CN(C)c1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 100-22-1 "N,N,N',N'-Tetramethyl-p-Phenylenediamine" CN(C)c1ccc(N(C)C)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 106-50-3 p-Phenylenediamine Nc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 108-45-2 m-Phenylenediamine Nc1cccc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 121-88-0 2-Amino-5-Nitrophenol Nc1ccc(N(=O)=O)cc1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 5307-14-2 2-Nitro-p-Phenylenediamine Nc1ccc(N)cc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 15972-60-8 Alachlor CCc1cccc(CC)c1N(COC)C(=O)CCl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 15481-70-6 "Toluene-2,6-diamine, dihydrochloride" Cc1c(N)cccc1N_Cl_Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 823-40-5 "2,6-diaminotoluene" Cc1c(N)cccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "ARMSTRONG,MJ, BEAN,CL AND GALLOWAY,SM; A QUANTITATIVE ASSESSMENT OF THE CYTOTOXICITY ASSOCIATED WITH CHROMOSOMAL ABERRATION DETECTION IN CHINESE HAMSTER OVARY CELLS; MUTAT. RES. 265(1):45-60, 1992" 91-08-7 "2,6-Toluene diisocyanate" Cc1c(N=C=O)cccc1N=C=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GULATI,DK.et al; III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989; JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996" 95-53-4 2-methylbenzenamine Cc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213." 88-85-7 dinoseb CCC(C)c1cc(N(=O)=O)cc(N(=O)=O)c1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Dinoseb- Study Report, ECHA Europa, OECD Gideline 473, February 2006; http://apps.echa.europa.eu/registered/data/dossiers/DISS-9d9d5546-37af-1230-e044-00144f67d249/AGGR-5d90f38f-b418-4186-af54-407fd3c8d17b_DISS-9d9d5546-37af-1230-e044-00144f67d249.html#GEN_DATA_SOURCE_HD" 23184-66-9 Butachlor CCCCOCN(C(=O)CCl)c1c(CC)cccc1CC in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Lin MF, Wu CL, Wang TC, Pesticide clastogenicity in CHO cells, Mutat. Res., 1987 Jul; 188(3):241-50" 106-49-0 4-Aminotoluene; p-toluidine Cc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213." 16055-80-4 L-Kynurenine_sulfate NC{P-}(CC(=O)c1ccccc1N)C(O)=O_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan." 95-85-2 2-Amino-4-chlorophenol Nc1cc(Cl)ccc1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 4; 2008" 26381-41-9 Basic brown 16 CN{+}(C)(C)(.Cl{-})c1ccc2ccc(O)c(N=Nc3ccc(N)cc3)c2c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS; CONCERNING BASIC BROWN 16COLIPA n° C9, adopted by the SCCNFP during the 23rd plenary meeting of 18 March 2003" 100-00-5 1-Chloro-4-nitrobenzene O=N(=O)c1ccc(Cl)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996" 5131-60-2 4-Chloro-m-phenylenediamine Nc1ccc(Cl)c(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996; Loveday, Ks., Anderson, Be., Resnick, Ma., Zeiger, E.; Chromosome Aberration And Sister Chromatid Exchange Tests In Chinese Hamster Ovary Cells In Vitro, V: Results With 46 Chemicals; Environ. Mol. Mutagen. 16(9):272-303, 1990" 95-83-0 4-chloro-o-phenylenediamine Nc1ccc(Cl)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; " 95-80-7 "Toluene-2,4-diamine" Cc1ccc(N)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; " 95-70-5 "2,5-diaminotoluene" Cc1cc(N)ccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Scientific Committee on Consumer Products OPINION ON Toluene-2,5-diamine COLIPA n° A5 The SCCP adopted this opinion at its 13th plenary meeting on 2 October 2007" 609-20-1 "2,6-dichloro-p-phenylenediamine" Nc1cc(Cl)c(N)c(Cl)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989" 20721-50-0 "2,2'-((4-((4-Aminophenyl)azo)phenyl)imino)bisethanol" Nc1ccc(N=Nc2ccc(N(CCO)CCO)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety OPINION ON Disperse Black 9 COLIPA n° C106 The SCCS adopted this opinion at its 6th plenary meeting of 23 March 2010 88-74-4 2-nitroaniline Nc1ccccc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL), 1997" 100-01-6 4-nitroaniline Nc1ccc(N(=O)=O)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987" 13552-44-8 Methylenedianiline dihydrochloride Cl_Cl_Nc1ccc(Cc2ccc(N)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989" 2185-92-4 2-Biphenylamine hydrochloride Cl_Nc1ccccc1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193" 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(N=Nc2ccccc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate, M. Jr, Harnois, M.C., Sofuni, T., A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 1988, 195(2), 151-213." 85-86-9 "2-naphthalenol, 1- 4-(phenylazo)phenyl azo -" Oc1ccc2ccccc2c1N=Nc1ccc(N=Nc2ccccc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Au, W, Hsu, T.C., Studies on the clastogenic effects of biologic stains and dyes. Environ. Mutagen., 1979,1(1), 27-35." 39156-41-7 "2,4-Diaminoanisole Sulfate" COc1ccc(N)cc1N_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 99-88-7 4-isopropylaniline;_p-Isopropylaniline CC(C)c1ccc(N)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 584-84-9 "Toluene 2,4-diisocyanate" Cc1ccc(N=C=O)cc1N=C=O in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "GULATI,DK. et al; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989" 1937-37-7 direct black 38 Nc1ccc(N=Nc2ccc(-c3ccc(N=Nc4c(S(=O)(=O)O{-}.[Na]{+})cc5cc(S(=O)(=O)O{-}.[Na]{+})c(N=Nc6ccccc6)c(O)c5c4N)cc3)cc2)c(N)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test http://ntp.niehs.nih.gov/testing/status/agents/ts-10886-n.html#Genetic-Toxicology 2832-40-8 c.i. disperse yellow 3 Cc1ccc(O)c(N=Nc2ccc(NC(C)=O)cc2)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ. Mol. Mutagen., 1989,14(3),165-187." 34432-92-3 n-ethyl-n-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline CCN(CCOC(C)OCC(C)C)c1ccc(N=Nc2ccccc2)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "N-Ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline, CAS No 34432-92-3. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/5682" 121-73-3 1-chloro-3-nitrobenzene O=N(=O)c1cccc(Cl)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175." 569-61-9 c.i. basic red 9 monohydrochloride Cl_Nc1ccc(C(=C2C=CC(=N)C=C2)c2ccc(N)cc2)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "NTP Toxicology and Carcinogenesis Studies of C.I. Basic Red 9 Monohydrochloride (Pararosaniline) (CAS No. 569-61-9) In F344/N Rats and B6C3F1 Mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1986, 285, 1-228." 16071-86-6 c.i. direct brown 95 O=C1C=CC(=NNc2cc3ccc2O{-}.[Cu]{2+}.O{-}S3(=O)=O)C(=O)C1=NNc1ccc(-c2ccc(N=Nc3ccc(O{-}.[Na]{+})c(C(=O)O{-}.[Na]{+})c3)cc2)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175." 137-09-7 "2,4-diaminophenol.2hcl" Cl_Cl_Nc1ccc(O)c(N)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175." 90-41-5 2-aminobiphenyl (2-phenylaniline) Nc1ccccc1-c1ccccc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test http://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF90-41-5f.pdf