CAS Chem.name Chem.SMILES #Obs_CA_with_S9 Bioassay - Reference(s) - 106-47-8 p-Chloroaniline Nc1ccc(Cl)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 108-69-0 "3,5-Xylidine" Cc1cc(C)cc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 55-80-1 3-Methyl-4'-(dimethylamino)azobenzene Cc1cccc(N=Nc2ccc(N(C)C)cc2)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 87-59-2 "2,3-Xylidine" Cc1cccc(N)c1C in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-51-2 o-Chloroaniline Nc1ccccc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 99-09-2 m-nitroaniline Nc1cccc(N(=O)=O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 134-32-7 1-Naphthylamine Nc1cccc2ccccc12 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 554-00-7 "2,4-Dichloroaniline" Nc1ccc(Cl)cc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 54-88-6 "n,n-dimethyl-4-(phenylazo)-m-toluidine" Cc1cc(N(C)C)ccc1N=Nc1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan." 91-23-6 o-nitroanizole COc1ccccc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996" 100-17-4 4-nitroanisole COc1ccc(N(=O)=O)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996" 54381-16-7 "ethanol, 2,2'-o(4-aminophenyl)iminoabis-, sulfate (1:1) (salt)" Nc1ccc(N(CCO)CCO)cc1_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "European Commission Health & Consumer Protection Directorate-GeneraL Directorate C - Public Health and Risk Assessment C7 - Risk assessment Scientific Committee On Consumer Products Opinion on N,N-bis(2-hydroxyethyl)-p-phenylenediamine sulfate COLIPA N° A50. Adopted by the SCCP during the 8th plenary meeting of 20 June 2006" 1936-15-8 c.i. acid orange 10 Oc1ccc2cc(S(=O)(=O)O{-}.[Na]{+})cc(S(=O)(=O)O{-}.[Na]{+})c2c1N=Nc1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ. Mol. Mutagen., 1989, 14(3), 165-187." 89-61-2 "1,4-Dichloro-2-nitrobenzene" O=N(=O)c1cc(Cl)ccc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 90-04-0 o-Anisidine COc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 93-05-0 "N,N-Diethyl-p-Phenylenediamine" CCN(CC)c1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 95-54-5 o-Phenylenediamine Nc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 99-98-9 "N,N-Dimethyl-p-Phenylenediamine" CN(C)c1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 100-61-8 Methyl-phenyl-amine CNc1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-14-4 "4,4'-Methylenebis(2-Chloroaniline)" Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 103-69-5 N-Ethylaniline CCNc1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 104-94-9 p-Anisidine COc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 108-45-2 m-Phenylenediamine Nc1cccc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 156-43-4 p-Phenetidine CCOc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 536-90-3 m-Anisidine COc1cccc(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1239-45-8 Homidium bromide CCn{+}1(.Br{-})c2cc(N)ccc2c2ccc(N)cc2c1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 3209-22-1 "2,3-Dichloronitrobenzene" O=N(=O)c1cccc(Cl)c1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 15481-70-6 "Toluene-2,6-diamine, dihydrochloride" Cc1c(N)cccc1N_Cl_Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 823-40-5 "2,6-diaminotoluene" Cc1c(N)cccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "ARMSTRONG,MJ, BEAN,CL AND GALLOWAY,SM; A QUANTITATIVE ASSESSMENT OF THE CYTOTOXICITY ASSOCIATED WITH CHROMOSOMAL ABERRATION DETECTION IN CHINESE HAMSTER OVARY CELLS; MUTAT. RES. 265(1):45-60, 1992" 42397-64-8 "1,6-Dinitropyrene" O=N(=O)c1ccc2ccc3c(N(=O)=O)ccc4ccc1c2c34 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 42397-65-9 "1,8-Dinitropyrene" O=N(=O)c1ccc2ccc3ccc(N(=O)=O)c4ccc1c2c34 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 87-62-7 "2,6-Xylidine" Cc1cccc(C)c1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-53-4 2-methylbenzenamine Cc1ccccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213." 67730-11-4 "2-amino-6-methyldipyrido(1,2-a:3',2'-d)imidazole; GLU-P-1" CC1=CC=CN2C1=Nc1ccc(N)nc21 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan." 106-49-0 4-Aminotoluene; p-toluidine Cc1ccc(N)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213." 100-00-5 1-Chloro-4-nitrobenzene O=N(=O)c1ccc(Cl)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996" 5131-60-2 4-Chloro-m-phenylenediamine Nc1ccc(Cl)c(N)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996; Loveday, Ks., Anderson, Be., Resnick, Ma., Zeiger, E.; Chromosome Aberration And Sister Chromatid Exchange Tests In Chinese Hamster Ovary Cells In Vitro, V: Results With 46 Chemicals; Environ. Mol. Mutagen. 16(9):272-303, 1990" 95-83-0 4-chloro-o-phenylenediamine Nc1ccc(Cl)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; " 95-80-7 "Toluene-2,4-diamine" Cc1ccc(N)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; " 95-70-5 "2,5-diaminotoluene" Cc1cc(N)ccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Scientific Committee on Consumer Products OPINION ON Toluene-2,5-diamine COLIPA n° A5 The SCCP adopted this opinion at its 13th plenary meeting on 2 October 2007" 99-54-7 "3,4-dichloronitrobenzene" O=N(=O)c1ccc(Cl)c(Cl)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005" 609-20-1 "2,6-dichloro-p-phenylenediamine" Nc1cc(Cl)c(N)c(Cl)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989" 119-93-7 Orthotolidine Cc1cc(-c2ccc(N)c(C)c2)ccc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987" 20721-50-0 "2,2'-((4-((4-Aminophenyl)azo)phenyl)imino)bisethanol" Nc1ccc(N=Nc2ccc(N(CCO)CCO)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety OPINION ON Disperse Black 9 COLIPA n° C106 The SCCS adopted this opinion at its 6th plenary meeting of 23 March 2010 88-74-4 2-nitroaniline Nc1ccccc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL), 1997" 101-80-4 "4,4'-oxydianiline" Nc1ccc(Oc2ccc(N)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989" 137-17-7 "2,4,5-trimethylaniline; trimethylaniline, 2,4,5-; 2,4,5trimethylaniline[1]" Cc1cc(C)c(C)cc1N in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "LOVEDAY,KS ANDERSON,BE RESNICK,MA ZEIGER,E; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO, V: RESULTS WITH 46 CHEMICALS; ENVIRON. MOL. MUTAGEN. 16(9):272-303, 1990" 13552-44-8 Methylenedianiline dihydrochloride Cl_Cl_Nc1ccc(Cc2ccc(N)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989" 2185-92-4 2-Biphenylamine hydrochloride Cl_Nc1ccccc1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193" 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(N=Nc2ccccc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate, M. Jr, Harnois, M.C., Sofuni, T., A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 1988, 195(2), 151-213." 85-86-9 "2-naphthalenol, 1- 4-(phenylazo)phenyl azo -" Oc1ccc2ccccc2c1N=Nc1ccc(N=Nc2ccccc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Au, W, Hsu, T.C., Studies on the clastogenic effects of biologic stains and dyes. Environ. Mutagen., 1979,1(1), 27-35." 39156-41-7 "2,4-Diaminoanisole Sulfate" COc1ccc(N)cc1N_OS(O)(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan" 56-57-5 4-Nitroquinoline-N-oxide O=n1ccc(N(=O)=O)c2ccccc12 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test "Ishidate Jr., M., and S. Odashima (1977) Mutation Res.,48, 337-354" 95-64-7 "3,4-Xylidine" Cc1ccc(N)cc1C in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 108-44-1 3-Aminotoluene Cc1cccc(N)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 611-06-3 "2,4-Dichloronitrobenzene" O=N(=O)c1ccc(Cl)cc1Cl in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-88-7 4-isopropylaniline;_p-Isopropylaniline CC(C)c1ccc(N)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1937-37-7 direct black 38 Nc1ccc(N=Nc2ccc(-c3ccc(N=Nc4c(S(=O)(=O)O{-}.[Na]{+})cc5cc(S(=O)(=O)O{-}.[Na]{+})c(N=Nc6ccccc6)c(O)c5c4N)cc3)cc2)c(N)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test http://ntp.niehs.nih.gov/testing/status/agents/ts-10886-n.html#Genetic-Toxicology 34432-92-3 n-ethyl-n-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline CCN(CCOC(C)OCC(C)C)c1ccc(N=Nc2ccccc2)cc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test "N-Ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline, CAS No 34432-92-3. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/5682" 90-41-5 2-aminobiphenyl (2-phenylaniline) Nc1ccccc1-c1ccccc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test http://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF90-41-5f.pdf