CAS Chem.name Chem.SMILES #Obs_CA_with_S9 Bioassay - Reference(s) - 92-52-4 Biphenyl c1ccccc1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 83-32-9 Acenaphthene C1Cc2cccc3cccc1c23 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 89-83-8 5-methyl-2-(1-methylethyl)phenol; Thymol CC(C)c1ccc(C)cc1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1570-64-5 4-Chloro-2-methyl-phenol Cc1cc(Cl)ccc1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 51630-58-1 Fenvalerate CC(C)C(c1ccc(Cl)cc1)C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Caballo C., Herrara A., Barrueco C., Santa-Maria A., Sanz F., De La Plena E., Analysis Of Cytogenetic Damage Induced In CHO Cells By The Pyrethroid Insecticide Fenvalerate, Terato. Carcino. Mutagen., 1992, 12(6), 243-249 92-88-6 [1,1'-biphenyl]-4,4'-diol Oc1ccc(-c2ccc(O)cc2)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 108-39-4 m-Cresol Cc1cccc(O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 108-73-6 Phloroglucinol; 1,3,5-Benzenetriol Oc1cc(O)cc(O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 121-79-9 Propyl Gallate CCCOC(=O)c1cc(O)c(O)c(O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 149-91-7 Gallic Acid Oc1cc(C(O)=O)cc(O)c1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 154-23-4 Catechin OC1Cc2c(cc(O)cc2O)OC1c1ccc(O)c(O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 396-01-0 Triamterene Nc1c2c(nc(N)c(-c3ccccc3)n2)nc(N)n1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 477-30-5 Colcemid CNC1CCc2cc(OC)c(OC)c(OC)c2C2=CC=C(OC)C(=O)C=C12 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1129-41-5 3-Methylphenyl_N-methylcarbamate Cc1cccc(OC(=O)NC)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1401-55-4 Tannic_acid OC1C(COC(=O)c2cc(O)c(O)c(O)c2)OC(OC(=O)c2cc(O)c(O)c(O)c2)C(O)C1OC(=O)c1cc(O)c(O)c(O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 2425-10-7 Phenol, 3,4-dimethyl-, methylcarbamate; Xylylcarb Cc1ccc(OC(=O)NC)cc1C in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 58139-33-6 3,4-Dimethylphenyl-N-nitroso-N-methylcarbamate Cc1ccc(OC(=O)N(C)N=O)cc1C in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 58139-35-8 3-Methylphenyl_N-nitroso_N-methylcarbamate Cc1cccc(OC(=O)N(C)N=O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Ishidate Jr., M., and S. Odashima (1977) Mutation Res.,48, 337-354. 60687-93-6 Lacchaic_acid CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(O)=O)c2C(O)=O)C3=O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 62450-06-0 Trp-P-1 Cc1c2c(c(C)c(N)n1)Nc1ccccc-21 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 62450-07-1 1-Methyl-9H-pyrido(4,3-b)indol-3-amine Cc1c2c(cc(N)n1)Nc1ccccc-21 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 2581-34-2 4-Nitro-3-cresol Cc1cc(O)ccc1N(=O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 91-76-9 1,3,5-triazine-2,4-diamine,_6-phenyl- Nc1nc(-c2ccccc2)nc(N)n1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 2416-94-6 2,3,6-trimethylphenol Cc1ccc(C)c(C)c1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 123-07-9 Phenol,_4-ethyl- CCc1ccc(O)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 620-17-7 Phenol, 3-ethyl- CCc1cccc(O)c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test SCREENING-LEVEL HAZARD CHARACTERIZATION OF HIGH PRODUCTION VOLUME CHEMICALS, March, 2008, INTERIM 89-72-5 O-sec-Butylphenol CCC(C)c1ccccc1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test M.Matsumoto, et.al, Bull.Natl.Inst. health Sci., 2011,129, 68-75 99-71-8 Phenol,_4-(1-methylpropyl)- CCC(C)c1ccc(O)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Kusakabe, H., Yamakage, K., Wakuri, S., Sasaki, K., Nakagawa, Y., Watanabe, M., Hayashi, M., Sofuni, T., Ono, H., Tanaka, N., Relevance of chemical structure and cytotoxicity to the induction of chromosome aberrations based on the testing results of 98 high production volume industrial chemicals. Mutat. Res., 2002, 517(1-2), 187-198. 59-92-7 Levodopa NC(Cc1ccc(O)c(O)c1)C(O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 90-43-7 1,1'-biphenyl-2-ol Oc1ccccc1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Tayama-Nawai, S., Yoshida, S., Nakao, T., Hiraga, K., Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol. Mutat. Res., 1984, 141(2), 95-99. 117-39-5 Quercetin Oc1ccc(C2=C(O)C(=O)c3c(cc(O)cc3O)O2)cc1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 132-27-4 O-Phenylphenate Sodium [Na]{+}.O{-}c1ccccc1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test ortho-PHENYLPHENOL AND ITS SODIUM SALT, IARC MONOGRAPHS VOLUME 73, p.451-480; Tayama, S. & Nakagawa, Y., Mutat. Res., 1991, 259, 1–12 550-10-7 Hydrocotarnine_hydrochloride CN1CCc2cc3c(c(OC)c2C1)OCO3 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 555-30-6 2-methyl-3-(3,4-dihydroxyphenyl)-L-alanine CC{P+}(N)(Cc1ccc(O)c(O)c1)C(O)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 1079-21-6 2,5-Dihydroxybiphenyl Oc1ccc(O)cc1-c1ccccc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test S.Tayama et al., Mutat.Res., 1989, 223(1), 23-33 58-90-2 2,3,4,6-Tetrachlorophenol Oc1c(Cl)cc(Cl)c(Cl)c1Cl in vitro CA positive in Vitro Mammalian Chromosome Aberration Test WORLD HEALTH ORGANIZATION, INTERNATIONAL AGENCY FOR RESEARCH ON CANCER - IARC, MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide VOLUME 71, p.796-816 6098-44-8 n-acetoxy-2-acetylaminofluorene CC(=O)N(c1ccc2c(Cc3ccccc-23)c1)OC(C)=O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Tates AD & Kriek E: Mutation Res., 88, 397-410 (1981) 68808-54-8 3-amino-1,4-dimethyl-5h-pyrido[4,3-b]indole acetate; (trp-p-1 acetate) Cc1c2c(c(C)c(N{+}.O{-}C(C)=O)n1)Nc1ccccc-21 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Motomichi SASAKI, Keiko SUGIMURA, Mitsuaki A. YoSHIDA, and Takashi KAWACHI. Chromosome Aberrations and Sister Chromatid Exchanges Induced by Tryptophan Pyrolysates, Trp.P.1 and Trp.P.2, in Cultured Human and Chinese Hamster Cells. Proc. Japan Acad., 56, Ser. B (1980) [Vol. 56(B) 26148-68-5 2-amino-9h-pyrido[2,3-b]indole; a-alpha-c; 2-amino-9h-pyrido(2,3-b)indole Nc1ccc2c(Nc3ccccc-23)n1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test IARC Monographs on the evaluation of the carcinogenic risk of chemicals to human, v. 40, 1986, pp. 245-252 518-28-5 podophyllotoxin COc1cc(C2C3C(COC3=O)C(O)c3cc4c(cc23)OCO4)cc(OC)c1OC in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Mei Chih Lin, Hui Wen Cheng, Yi Chen Tsai, Po Lin Liao, Jaw Jou Kang, and Yu Wen Cheng; Podophyllin, but not the constituents quercetin or kaempferol, induced genotoxicity in vitro and in vivo through ROS production; Drug Chem Toxicol, January 2009, Vol. 32, No. 1 , Pages 68-76 87-66-1 pyrogallol (1,2,3-trihydroxybenzene) Oc1cccc(O)c1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test SILVA,MDC GASPAR,J SILVA,ID LEAO,D AND RUEFF,J INDUCTION OF CHROMOSOMAL ABERRATIONS BY PHENOLIC COMPOUNDS: POSSIBLE ROLE OF REACTIVE OXYGEN SPECIES; MUTAT. RES. 540(1):29-42, 2003 2380-86-1 6-Hydroxyindole Oc1ccc2C=CNc2c1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS Opinion on 6-Hydroxyindole COLIPA N° A128 Adopted by the SCCP during the 7th plenary meeting of 28 March 2006 SCCP/0947/05 23214-92-8 doxorubicin; adriamycin CC1C(O)C(N)CC(OC2CC(O)(C(=O)CO)Cc3c2c(O)c2c(c3O)C(=O)c3cccc(OC)c3C2=O)O1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Dr. William W. Au, Dennis A. Johnston, Cheryl Collie-Bruyere andT. C. Hsu; Short-term cytogenetic assays of nine cancer chemotherapeutic drugs with metabolic activation, Environmental Mutagenesis Volume 2, Issue 4, pages 455–464, 1980 123577-49-1 4-Hydroxymethyl-4',5'-benzopsoralen OCC1=CC(=O)Oc2cc3c(cc12)-c1ccccc1O3 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Pani, B., M. Barbisin, E. Russo, M. Tamaro, F. Baccichetti, F. Carlassare, C. Marzano, P. Rodighiero, F. Bordin, DNA Damage and Topoisomerase II Inhibition Induced by a Benzopsoralen Derivative, Mutat. Res. 311 (1994), 277 – 285 106-44-5 p-cresol Cc1ccc(O)cc1 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test p-Cresol, CAS No 106-44-5. ECHA Legal notice, Registration dossier. https://echa.europa.eu/registration-dossier/-/registered-dossier/15980 912-60-7 Noscapine hydrochloride CN{+}1(.Cl{-})CCc2cc3c(c(OC)c2C{P+}1C{P-}1c2ccc(OC)c(OC)c2C(=O)O1)OCO3 in vitro CA positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1333-16-0 Bisphenol F (mixed isomers) Oc1ccccc1Cc1ccccc1O in vitro CA positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 108-88-3 Toluene Cc1ccccc1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1843-05-6 Octabenzone; (2-Hydroxy-4-(octyloxy)phenyl)phenylmethanone CCCCCCCCOc1ccc(C(=O)c2ccccc2)c(O)c1 in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 6165-51-1 Benzene, 1,4-dimethyl-2-(1-phenylethyl)- CC(c1ccccc1)c1cc(C)ccc1C in vitro CA negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan