CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 89459-25-6 n-[2-(dimethylamino)ethyl]-4-acridinecarboxamide;acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide CN(C)CCNC(=O)c1cccc2cc3ccccc3nc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 103554-58-1 n-[2-(dimethylamino)ethyl]-9,10-dihydro-9-oxo-4-acridinecarboxamide CN(C)CCNC(=O)c1cccc2c1Nc1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 103942-97-8 n-[2-(dimethylamino)ethyl]-1-phenazinecarboxamide CN(C)CCNC(=O)c1cccc2c1nc1ccccc1n2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 106626-55-5 n-[2-(dimethylamino)ethyl]-1-acridinecarboxamide;acridine-1-carboxylic acid (2-dimethylamino-ethyl)-amide CN(C)CCNC(=O)c1cccc2c1cc1ccccc1n2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 112022-07-8 n-[2-(dimethylamino)ethyl]-9-oxo-9h-thioxanthene-4-carboxamide CN(C)CCNC(=O)c1cccc2c1Sc1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 112022-08-9 n-[2-(dimethylamino)ethyl]-9-oxo-9h-xanthene-4-carboxamide CN(C)CCNC(=O)c1cccc2c1Oc1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 10048-13-2 Sterigmatocystin COc1cc2c(C3C=COC3O2)c2c1C(=O)c1c(cccc1O)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 479-50-5 Lucanthone; miracild; 1-{[2-(diethylamino)ethyl]amino}-4-methyl-9h-thioxanthen-9-one CCN(CC)CCNc1ccc(C)c2c1C(=O)c1ccccc1S2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2798-25-6 Bellidifolin COc1cc2c(c(O)c1)C(=O)c1c(O)ccc(O)c1O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2980-32-7 Desmethylbellidifolin Oc1ccc(O)c2c1C(=O)c1c(cc(O)cc1O)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 3722-54-1 1,3,7-trimethoxyxanthone COc1ccc2c(c1)C(=O)c1c(OC)cc(OC)cc1O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 5557-27-7 Dimethylbellidifolin COc1ccc(O)c2c1Oc1cc(OC)cc(OC)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 17948-33-3 Rutacridone CC(=C)C1Cc2c(cc(O)c3c2N(C)c2ccccc2C3=O)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-53-6 Austocystin d CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(c(O)c1C2=O)C1(O)C=COC1O3 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) KFIR,R, JOHANNSEN,E AND VLEGGAAR,R; BULL. ENVIRON. CONTAM. TOXICOL. 37(5):643650, 1986 55256-55-8 Austocystin c CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(C4C=COC4O3)c(OC)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-57-0 Austocystin b CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(C4C=COC4O3)c(O)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-58-1 Austocystin A COc1c(Cl)ccc2c1C(=O)c1c(cc3c(C4C=COC4O3)c1OC)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 58775-50-1 Austocystin h CC(C)=CCc1ccc(O)c2c1Oc1cc3c(c(O)c1C2=O)C1(O)C=COC1O3 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) KFIR,R, JOHANNSEN,E AND VLEGGAAR,R; BULL. ENVIRON. CONTAM. TOXICOL. 37(5):643650, 1986 62512-94-1 Isogravacridone chlorine CC(O)(CCl)C1Cc2c(cc(O)c3c2N(C)c2ccccc2C3=O)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 77996-03-3 Rutacridone epoxide CC1(C2Cc3c(cc(O)c4c3N(C)c3ccccc3C4=O)O2)CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 138154-39-9 5-((2-diethylamino)ethyl)amino)-8-hydroxy-6h-imidazo(4,5,1-de)acridin-6-one;c 1311 CCN(CC)CCNc1ccc2c3c1C(=O)c1cc(O)ccc1N3C=N2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Berger, B., Marquardt, H. and Westendorf, J.; Pharmacological and Toxicological Aspects of new Imidazoacridinone Antitumor Agents; Cancer Res. 56(9):2094-2104, 1996 138154-40-2 5-((2-(diethylamino)ethyl)amino)-8-hydroxy-1-methyl-6h-imidazo(4,5,1-de)acidin-6-one;c 1310 CCN(CC)CCNc1ccc2c3c1C(=O)c1cc(O)ccc1N3C(C)=N2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Berger, B., Marquardt, H. and Westendorf, J.; Pharmacological and Toxicological Aspects of new Imidazoacridinone Antitumor Agents; Cancer Res. 56(9):2094-2104, 1996 89458-99-1 n-[2-(dimethylamino)ethyl]-4-acridinecarboxamide, dihydrochloride Cl_Cl_CN(C)CCNC(=O)c1cccc2cc3ccccc3nc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 23255-93-8 Hycanthone methanesulfonate; Hycanthone mesylate CCN{+}(CC)(CCNc1ccc(CO)c2c1C(=O)c1ccccc1S2).O{-}S(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 553-30-0 Proflavine sulfate Nc1ccc2cc3ccc(N)cc3nc2c1_OS(O)(=O)=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 3105-97-3 Hycanthone CCN(CC)CCNc1ccc(CO)c2c1C(=O)c1ccccc1S2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 8048-52-0 Acriflavine Cn{+}1(.Cl{-})c2cc(N)ccc2cc2ccc(N)cc12_Nc1ccc2cc3ccc(N)cc3nc2c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Brown, Jp. and Brown, Rj.; Mutagenesis by 9,10-Anthraquinone Derivatives and Related Compounds in Salmonella Typhimurium; Mutat. Res. 40:203-224, 1976