CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 512-56-1 Trimethylphosphate COP(=O)(OC)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 52-68-6 Trichlorfon COP(=O)(C(O)C(Cl)(Cl)Cl)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 60-51-5 Dimethoate CNC(=O)CSP(=S)(OC)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 62-73-7 Dichlorvos COP(=O)(OC)OC=C(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 78-34-2 Dioxathion CCOP(=S)(OCC)SC1C(SP(=S)(OCC)OCC)OCCO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 301-12-2 Metasystox-R CCS(=O)CCSP(=O)(OC)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 55-38-9 Fenthion Cc1cc(OP(=S)(OC)OC)ccc1SC in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 86-50-0 Gusathion COP(=S)(OC)SCN1C(=O)c2ccccc2N=N1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 126-72-7 Tris(2,3-Dibromopropyl)Phosphate O=P(OCC(Br)CBr)(OCC(Br)CBr)OCC(Br)CBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 298-00-0 Methyl parathion COP(=S)(OC)Oc1ccc(cc1)[N+](=O)[O-] in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 13674-87-8 Tris(1,3-Dichloro-2-Propyl)Phosphate O=P(OC(CCl)CCl)(OC(CCl)CCl)OC(CCl)CCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 640-15-3 Thiometon; s-[2-(ethylsulfanyl)ethyl] o,o-dimethyl phosphorodithioate CCSCCSP(=S)(OC)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Moriya,M Ohta,T Watanabe,K Miyazawa,T Kato,K and SHIRASU,Y; FURTHER MUTAGENICITY STUDIES ON PESTICIDES IN BACTERIAL REVERSION ASSAY SYSTEMS; MUTAT. RES. 116(3-4):185-216,1982 122-14-5 Fenitrothion COP(=S)(OC)Oc1ccc(c(C)c1)[N+](=O)[O-] in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kirkland et. al. Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop, Mutat. Res., 2014, (775-776), 55-68 92118-27-9 Fotemustine CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ashby, J, et. el.; Mutagenicity to Salmonella, Drosophila and the Mouse Bone Marrow of the Human Antineoplastic Agent Fotemustine: Prediction Of Carcinogenic Potency; Mutat. Res. 286(1):101- 109, 1993 42509-80-8 Isazofos; o-(5-chloro-1-isopropyl-1,2,4-triazol-3-yl) o,o-diethyl phosphorothioate CCOP(=S)(OCC)OC1=NN(C(C)C)C(Cl)=N1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SIERRA-TORRES,CH, CAJAS-SALAZAR,N, HOYOS,LS, ZULETA,M, WHORTON,EB AND AU,WW; IN VITRO AND IN VIVO GENOTOXIC ACTIVITY OF MIRAL, AN ORGANOPHOSPHORUS INSECTICIDE USED IN COLOMBIA; MUTAT. RES. 415(1-2):59-67, 1998 6923-22-4 Monocrotophos; dimethyl (2e)-4-(methylamino)-4-oxobut-2-en-2-yl phosphate CC(=CC(=O)NC)OP(=O)(OC)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hour,TC, Chen,L and Lin,JK; COMPARATIVE INVESTIGATION ON THE MUTAGENICITIES OF ORGANOPHOSPHATE, PHTHALIMIDE, PYRETHROID AND CARBAMATE INSECTICIDES BY THE AMES AND LACTAM TESTS; MUTAGENESIS 13(2):157-166, 1998] 732-11-6 Phosmet COP(=S)(OC)SCN1C(=O)c2ccccc2C1=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) VLCKOVA,V, MIADOKOVA,E, PODSTAVKOVA,S AND VLCEK,D; MUTAGENIC ACTIVITY OF PHOSMET, THE ACTIVE COMPONENT OF THE ORGANOPHOSPHORUS INSECTICIDE DECEMTIONE EK 20 IN SALMONELLA AND SACCHAROMYCES ASSAYS; MUTAT. RES. 302(3):153-156, 1993 13171-21-6 Phosphamidon CCN(CC)C(=O)C(Cl)=C(C)OP(=O)(OC)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) VISHWANATH,R AND JAMIL,K; MUTAGENIC AND GENOTOXIC ACTIVITIES OF CERTAIN ORGANOPHOSPHORUS COMPOUNDS, USING AMES SALMONELLA ASSAY, WITH AND WITHOUT MICROSOMAL INDUCTION; INDIAN J. EXP. BIOL. 24(5):305-308, 1986 78-38-6 Diethyl ethylphosphonate CCOP(=O)(CC)OCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 78-40-0 Triethyl phosphate CCOP(=O)(OCC)OCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 78-42-2 tris(2-ethylhexyl)ester phosphoric acid CCCCC(CC)COP(=O)(OCC(CC)CCCC)OCC(CC)CCCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 78-51-3 Tri(2-butoxyethyl) phosphate CCCCOCCOP(=O)(OCCOCCCC)OCCOCCCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 121-75-5 Malathion CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 126-73-8 Tributyl phosphate CCCCOP(=O)(OCCCC)OCCCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1241-94-7 Phosphoric acid,2-ethylhexyl diphenyl ester CCCCC(CC)COP(=O)(Oc1ccccc1)Oc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1806-54-8 tri-N-Octyl Phosphate CCCCCCCCOP(=O)(OCCCCCCCC)OCCCCCCCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 50957-96-5 Sodium lauryl phosphate CCCCCCCCCCCCOP(O)(=O)O{-}.[Na]{+} in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 107-66-4 Dibutyl phosphate CCCCOP(O)(=O)OCCCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan