CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity without S9	#Observed Mutagenicity with S9	Bioassay - 	Reference(s) -
17070-44-9	ICR 191	COc1ccc2c(c1)c(NCCCNCCCl)c1ccc(Cl)cc1n2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
69-05-6	Quinacrine 2HCL	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
17070-45-0	1,3-Propanediamine,_N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-,_dihydrochloride	COc1ccc2c(c1)c(N{+}(.Cl{-})CCCN{+}(.Cl{-})CCCl)c1ccc(Cl)cc1n2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
*6-00-2	ICR 449	ClCCNCCCNc1c2ccccc2nc2ccccc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-6	ICR 411	COc1ccc2c(c1)c(NCCNCCCl)c1ccccc1n2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-7	ICR 376	COc1ccc2c(c1)c(NCCCNCCCl)c1ccccc1n2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-8	ICR 224	CCN(CCCNc1c2ccccc2nc2ccc(OC)cc12)CCCl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-00-9	ICR 442	CC(Cl)CNCCNc1c2ccccc2nc2ccc(OC)cc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-0	ICR 410	COc1cccc2c1nc1ccccc1c2NCCNCCCl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
92279-99-7	ICR 391	COc1cccc2c1nc1ccccc1c2NCCCNCCCl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
*6-01-1	ICR 377	CCN(CCCNc1c2ccccc2nc2c1cccc2OC)CCCl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-2	ICR 171	COc1ccc2c(c1)c(NCCNCCCl)c1ccc(Cl)cc1n2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-3	ICR 443	CC(Cl)CNCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-01-4	ICR 397	CCN(CCOCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12)CCCl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-1	ICR 370	ClCCNCCCNc1c2ccccc2nc2c1ccc1ccccc21	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-2	ICR 292	CCN(CCCNc1c2ccccc2nc2c1ccc1ccccc21)CCCl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-3	ICR 395	ClCCNCCCNc1c2ccccc2nc2c1ccc1cccnc21	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-4	ICR 368	CCN(CCCNc1c2ccccc2nc2c1ccc1cccnc21)CCCl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
*6-02-5	ICR 455	ClCCNCCCNc1c2ccccc2nc2c1ccc1cnccc21	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
4213-45-0	Quinacrine mustard dihydrochloride; Acridine,9-4-bis(2-chloroethyl)amino-1-methylbutyl amino-6-chloro-2-metho	CC(CCCN(CCCl)CCCl)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12_Cl_Cl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
146-59-8	Acridine mustard (ICR 170)	CCN(CCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12)CCCl_Cl_Cl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
90-45-9	9-Aminoacridine	Nc1c2ccccc2nc2ccccc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
89459-43-8	N-((2-Dimethylamino)ethyl)-9-aminoacridine-4-carboxamide	CN(C)CCNC(=O)c1cccc2c1nc1ccccc1c2N	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
*6-02-6	ICR 312	ClCCNCCNc1c2ccccc2nc2c1ccc1ccccc21	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
38915-49-0	2-Ethanediamine, N-benz(c)acridin-7-yl-N'-(2-chloroethyl)-, dihydrochloride, hydrate; ICR 312	Cl_Cl_ClCCNCCNc1c2ccccc2nc2c1ccc1ccccc21_O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
38914-97-5	ICR 217	CCN(CCCNc1c2ccccc2nc2ccccc12)CCCl_Cl_Cl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199
553-30-0	Proflavine sulfate	Nc1ccc2cc3ccc(N)cc3nc2c1_OS(O)(=O)=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
51264-14-3	Amsacrine; Methanesulfonamide, n-[4-(9-acridinylamino)-3-methoxyphenyl]-	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	FERGUSON,LR, VAN ZIJL,P AND BAGULEY,BC; COMPARISON OF THE MUTAGENICITY OF AMSACRINE WITH THAT OF A NEW CLINICAL ANALOGUE, CI-921; MUTAT. RES. 204(2): 207-217, 1988
8048-52-0	Acriflavine	Cn{+}1(.Cl{-})c2cc(N)ccc2cc2ccc(N)cc12_Nc1ccc2cc3ccc(N)cc3nc2c1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Brown, Jp. and Brown, Rj.; Mutagenesis by 9,10-Anthraquinone Derivatives and Related Compounds in Salmonella Typhimurium; Mutat. Res. 40:203-224, 1976