CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity without S9	#Observed Mutagenicity with S9	Bioassay - 	Reference(s) -
2581-34-2	4-Nitro-3-cresol	Cc1cc(O)ccc1[N+]([O-])=O	in vitro Ames negative	in vitro Ames negative	Bacterial Reverse Mutation Assay (e.g. Ames Test)	NIHS Japan
121-66-4	2-amino-5-nitrothiazole	[O-][N+](=O)C1SC(=N)NC=1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
139-94-6	Nithiazide	CCNC(=O)Nc1ncc(s1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
24554-26-5	N-[4-(5-Nitro-2-Furyl)-2-Thiazolyl]Formamide	[O-][N+](=O)c1ccc(o1)-c1csc(NC=O)n1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
3688-53-7	2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide	NC(=O)C(=Cc1ccc(o1)[N+]([O-])=O)c1ccco1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
443-48-1	Metronidazole	Cc1ncc(n1CCO)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
446-86-6	Azathioprine	Cn1cnc(c1Sc1ncnc2[nH]cnc12)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
7166-19-0	Beta-Bromo-Beta-Nitrostyrene	[O-][N+](=O)C(Br)=Cc1ccccc1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
584-48-5	1-bromo-2,4-dinitrobenzene	[O-][N+](=O)c1ccc(Br)c(c1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
59-87-0	Nitrofurazone	NC(=O)NN=Cc1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240
102-96-5	beta-Nitrostyrene	[O-][N+](=O)C=Cc1ccccc1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
38514-71-5	Anft; 2-amino-4-(5-nitro-2-furyl)thiazole	Nc1nc(cs1)-c1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215
22994-85-0	Benznidazole; 1h-imidazole-1-acetamide, 2-nitro-n-(phenylmethy	[O-][N+](=O)c1nccn1CC(=O)NCc1ccccc1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	FERREIRA,RCC AND FERREIRA,LCS; MUTAGENICITY OF NIFURTIMOX AND BENZNIDAZOLE IN THE SALMONELLA/MICROSOME ASSAY; BRAZ. J. MED. BIOL. RES. 19(1):19-25, 1986
720-69-4	4,6-diamino-2-(5-nitro-2-furyl)-1,3,5-triazine	Nc1nc(N)nc(n1)-c1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215
33389-33-2	1,2-dihydro-2-(5-nitro-2-thienyl)quinazoline-4-(3h)-one	[O-][N+](=O)c1ccc(s1)C1NC(=O)c2ccccc2N1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	MCCANN,J, CHOI,E, YAMASAKI,E AND AMES,BN; DETECTION OF CARCINOGENS AS MUTAGENS IN THE SALMONELLA/MICROSOME TEST: ASSAY OF 300 CHEMICALS; PROC. NATL. ACAD. SCI. USA 72(12):5135-5139, 1975
55738-54-0	trans-2-[(dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazo	CN(C)CN=C1NN=C(O1)C=Cc1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	NCI; THE SALMONELLA TYPHIMURIUM/MAMMALIAN MICROSOMAL ASSAY: A REPORT OF THE U.S. ENVIRONMENTAL PROTECTION AGENCY GENE-TOX PROGRAM; MUTAT RES 168:69-240,1986
26049-69-4	2-(2,2-dimethylhydrazino)-4-(5-nitro-2-furyl)thiazole	CN(C)Nc1nc(cs1)-c1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215
551-92-8	1,2-dimethyl-5-nitroimidazole	Cc1ncc(n1C)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	VANELLE,P, DE MEO,MP, MALDONADO,J, NOUGUIER,R, CROZET,MP, LAGET,M AND DUMENIL,G; GENOTOXICITY IN OXAZOLIDINE DERIVATIVES: INFLUENCE OF THE NITRO GROUP; EUR. J. MED. CHEM. 25(3):241-250, 1990
3570-75-0	Nifurthiazole; formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide	[O-][N+](=O)c1ccc(o1)-c1csc(NNC=O)n1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
33389-36-5	Quinazoline, 4-(2-hydroxyethylamino)-2-(5-nitro-2-thienyl)-	OCCNc1nc(nc2ccccc12)-c1ccc(s1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	MCCANN,J, CHOI,E, YAMASAKI,E AND AMES,BN; DETECTION OF CARCINOGENS AS MUTAGENS IN THE SALMONELLA/MICROSOME TEST: ASSAY OF 300 CHEMICALS; PROC. NATL. ACAD. SCI. USA 72(12):5135-5139, 1975
5036-03-3	1-(2-hydroxyethyl)-3-[(5-nitrofurfurylidene)amino]-2-imidazolidinone;nifurdazil	OCCN1CCN(N=Cc2ccc(o2)[N+]([O-])=O)C1=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
19622-55-0	cl 64855	Cn1c(ncc1[N+]([O-])=O)-c1nnc(N)s1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	FERREIRA,RCC AND FERREIRA,LCS; MUTAGENICITY OF CL 64855, A POTENT ANTI-TRYPANOSOMA CRUZI DRUG; MUTAT. RES. 171(1):11-15, 1986
75965-74-1	7-methoxy-2-nitronaphtho[2,1-b]furan	COc1ccc2c(ccc3oc(cc23)[N+]([O-])=O)c1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Castelain, Pet. al.; Mutagenic Activity of Dichloroethylamino Derivatives of Nitronaphthofuran and Some Nitrobenzofurans in the Salmonella/Microsome Assay; Mutat. Res. 280(1):9-15, 1992
21638-36-8	Nifurimide	CC1CN(N=Cc2ccc(o2)[N+]([O-])=O)C(=O)N1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
13551-87-6	Misonidazole; 1(2-oh-3-meo-pr)-2-nitroimidazole	COCC(O)Cn1ccnc1[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Brusick,Dj, Simmon,Vf, ROSENKRANZ,HS, RAY,VA AND STAFFORD,RS; AN EVALUATION OF THE ESCHERICHIA COLI WP2 AND WP2UVRA REVERSE MUTATION ASSAY; MUTAT. RES. 76:169-190, 1980][CHESSIN,H, MCLAUGHLIN,T, MROCZKOWSKI,Z, RUPP,WD AND LOW,KB; RADIOSENSITIZATION, MUTAGENICITY AND TOXICITY OF ESCHERICHIA COLI BY SEVERAL NITROFURANS AND NITROIMIDAZOLES; RADIAT. RES. 75:424-431, 1978
58139-48-3	4-morpholino-2-(5-nitro-2-thienyl)quinazoline	[O-][N+](=O)c1ccc(s1)-c1nc2ccccc2c(n1)N1CCOCC1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
23256-30-6	Nifurtimox	CC1CS(=O)(=O)CCN1N=Cc1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	FERREIRA,RCC AND FERREIRA,LCS; MUTAGENICITY OF NIFURTIMOX AND BENZNIDAZOLE IN THE SALMONELLA/MICROSOME ASSAY; BRAZ. J. MED. BIOL. RES. 19(1):19-25, 1986
36133-88-7	n-{[3-(5-nitro-2-furyl)-1,2,4-oxadiazole-5-yl]-methyl}acetamide	CC(=O)NCc1nc(no1)-c1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
2578-75-8	n-(5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl)acetamide	CC(=O)Nc1nnc(s1)-c1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
531-82-8	n-(4-(5-nitro-2-furyl)-2-thiazolyl)acetamide	CC(=O)Nc1nc(cs1)-c1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215
51325-35-0	n,n'-[6-(5-nitro-2-furyl)-s-triazine-2,4-diyl]bisacetamide	CC(=O)Nc1nc(NC(C)=O)nc(n1)-c1ccc(o1)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
19387-91-8	Tinidazole	CCS(=O)(=O)CCn1c(C)ncc1[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	GUPTA,RL, VATS,V AND JUNEJA,TR; ACTIVATION OF TINIDAZOLE, AN ANTIPROTOZOAL DRUG TO A MUTAGEN BY MAMMALIAN LIVER S9; MUTAT. RES. 370(3-4):195-201, 1996
67-20-9	Nitrofurantoin	[O-][N+](=O)c1ccc(C=NN2CC(=O)NC2=O)o1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240