CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity without S9	#Observed Mutagenicity with S9	Bioassay - 	Reference(s) -
69-05-6	Quinacrine 2HCL	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
4213-45-0	Quinacrine mustard dihydrochloride	CC(CCCN(CCCl)CCCl)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12_Cl_Cl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
89459-25-6	n-[2-(dimethylamino)ethyl]-4-acridinecarboxamide	CN(C)CCNC(=O)c1cccc2cc3ccccc3nc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
103554-58-1	n-[2-(dimethylamino)ethyl]-9,10-dihydro-9-oxo-4-acridinecarboxamide	CN(C)CCNC(=O)c1cccc2c1Nc1ccccc1C2=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
103942-97-8	n-[2-(dimethylamino)ethyl]-1-phenazinecarboxamide	CN(C)CCNC(=O)c1cccc2c1nc1ccccc1n2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
106626-55-5	n-[2-(dimethylamino)ethyl]-1-acridinecarboxamide	CN(C)CCNC(=O)c1cccc2c1cc1ccccc1n2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
107027-12-3	n-[2-(dimethylamino)ethyl]-2-phenyl-8-quinolinecarboxamide	CN(C)CCNC(=O)c1cccc2ccc(-c3ccccc3)nc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
107027-31-6	n-[2-(dimethylamino)ethyl]-3-phenyl-5-quinoxalinecarboxamide	CN(C)CCNC(=O)c1cccc2c1nc(-c1ccccc1)cn2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
112022-05-6	n-[2-(dimethylamino)ethyl]-1-anthracenecarboxamide	CN(C)CCNC(=O)c1cccc2cc3ccccc3cc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
112022-06-7	n-[2-(dimethylamino)ethyl]-9,10-dihydro-9,10-dioxo-1-anthracenecarboxamide	CN(C)CCNC(=O)c1cccc2c1C(=O)c1ccccc1C2=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
112022-07-8	n-[2-(dimethylamino)ethyl]-9-oxo-9h-thioxanthene-4-carboxamide	CN(C)CCNC(=O)c1cccc2c1Sc1ccccc1C2=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
112022-08-9	n-[2-(dimethylamino)ethyl]-9-oxo-9h-xanthene-4-carboxamide	CN(C)CCNC(=O)c1cccc2c1Oc1ccccc1C2=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
112022-10-3	n-[2-(dimethylamino)ethyl]dibenzo[b,e][1,4]dioxin-1-carboxamide	CN(C)CCNC(=O)c1cccc2c1Oc1ccccc1O2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
112022-13-6	n-[2-(dimethylamino)ethyl]-10h-phenoxazine-1-carboxamide	CN(C)CCNC(=O)c1cccc2c1Nc1ccccc1O2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
124340-47-2	n-[2-(dimethylamino)ethyl]-2-phenyl-1h-benzimidazole-4-carboxamide	CN(C)CCNC(=O)c1cccc2c1N=C(c1ccccc1)N2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
131862-15-2	n-[2-(dimethylamino)ethyl]-4-phenanthridinecarboxamide	CN(C)CCNC(=O)c1cccc2c1ncc1ccccc21	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
131862-17-4	n-[2-(dimethylamino)ethyl]benzo[f]quinoline-5-carboxamide	CN(C)CCNC(=O)c1cc2ccccc2c2cccnc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
131862-22-1	n-[2-(dimethylamino)ethyl]-2-phenyl-7-benzofurancarboxamide	CN(C)CCNC(=O)c1cccc2C=C(c3ccccc3)Oc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Denny, Wa.,  et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990
89459-43-8	N-((2-Dimethylamino)ethyl)-9-aminoacridine-4-carboxamide	CN(C)CCNC(=O)c1cccc2c1nc1ccccc1c2N	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
89458-99-1	n-[2-(dimethylamino)ethyl]-4-acridinecarboxamide, dihydrochloride	Cl_Cl_CN(C)CCNC(=O)c1cccc2cc3ccccc3nc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
54-05-7	Chloroquine	CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	ESPINOSA-AGUIRRE,JJ, SANTOS,JR AND DE NAVA,CC; INFLUENCE OF THE UVR REPAIR SYSTEM ON THE MUTAGENCIITY OF ANTIPARASITIC DRUGS; MUTAT. RES. 222(3):161-166, 1989
90-34-6	Primaquine;1,4-Pentanediamine	CC(CCCN)Nc1cc(OC)cc2cccnc12	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Chatterjee, T., A. Muhkopadhyay, K. A. Khan, A. K. Giri, Comparative Mutagenic and Genotoxic Effects of Three Antimalarial Drugs, Chloroquine, Primaquine and Amodiaquine, Mutagen. 13(6) (1998), 619 – 624