CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity without S9	#Observed Mutagenicity with S9	Bioassay - 	Reference(s) -
77439-76-0	3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone;mx;3-chloro-4-dichloromethyl-5-hydroxy-2-furanone	OC1C(C(Cl)Cl)=C(Cl)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25"
766-40-5	"3,4-dichloro-5-hydroxy-2(5h)-furanone;3,4-dichloro-5-hydroxyfuran-2(5h)-one"	OC1C(Cl)=C(Cl)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25"
112309-61-2	3-chloro-4-methyl-5-hydroxy-2(5h)-furanone	CC1C(O)OC(=O)C=1Cl	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, COOK,GP, PERAKYLA,H AND BU,L, CHEM. RES. TOXICOL. 4(5):540545, 1991; SHAUGHNESSY,DT OHE,T LANDI,S WARREN,SH RICHARD,AM MUNTER,T FRANZEN,R KRONBERG,L AND DEMARINI,DM; ENVIRON. MOL. MUTAGEN. 35(2):106113, 2000"
31555-54-1	"3,4-dichloro-5-dichloromethylene-2-furanone"	O=C1C(Cl)=C(Cl)C(=C(Cl)Cl)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25"
97055-38-4	3-chloro-4-(dichloromethyl)-5-methoxy-2(5h)-furanone	COC1C(C(Cl)Cl)=C(Cl)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25"
112654-68-9	3-chloro-5-dichloromethylene-2-furanone	O=C1C(Cl)=CC(=C(Cl)Cl)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"SMEDS,A, FRANZEN,R AND KRONBERG,L; ENVIRON. SCI. TECHNOL. 29(9):18391844, 1995"
122551-89-7	3-chloro-4-(dichloromethyl)-2(5h)-furanone;3-chloro-4-(dichloromethyl)-2-(5h)-furanone	O=C1C(Cl)=C(C(Cl)Cl)CO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, COOK,GP, PERAKYLA,H, DENCE,CW AND BABISH,JG; ENVIRON. MOL. MUTAGEN. 17(1):4048, 1991; KRONBERG,L, CHRISTMAN,RF, SINGH,R, AND BALL,LM; ENVIRON. SCI. TECHNOL. 25(1):99104, 1991"
125974-01-8	3-chloro-4-(chloromethyl)-2(5h)-furanone	O=C1C(Cl)=C(CCl)CO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, COOK,GP, PERAKYLA,H AND BU,L,  CHEM. RES. TOXICOL. 4(5):540545, 1991; LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L; CHEM. RES. TOXICOL. 10(12):14271436, 1997"
125974-08-5	3-chloro-4-(chloromethyl)-5-hydroxy-2(5h)-furanone	OC1C(CCl)=C(Cl)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, COOK,GP, PERAKYLA,H AND BU,L,  CHEM. RES. TOXICOL. 4(5):540545, 1991; LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L; CHEM. RES. TOXICOL. 10(12):14271436, 1997; NIITTYKOSKI,M, HYTTINEN,JMT AND JANSSON,K; MUTAT. RES. 348(1):5155, 1995"
132059-51-9	3-chloro-4-(bromochloromethyl)-5-hydroxy-2(5h)-furanone	OC1C(C(Cl)Br)=C(Cl)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"SUZUKI,N AND MATSUO,T; J. FAC. ENG. UNIV. TOKYO, SER.B 42(4):307315, 1994; RAMOS,I LLOVERAS,M SOLANS,X HUICI,A AND MESSEGUER,A; ENVIRON. TOXICOL. CHEM. 19(11):26312636, 2000; RAMOS,I LLOVERAS,M SOLANS,X HUICI,A AND MESSEGUER,A; ENVIRON. TOXICOL. CHEM. 19(11):26312636, 2000"
132059-52-0	3-chloro-4-(dibromomethyl)-5-hydroxy-2(5h)-furanone	OC1C(C(Br)Br)=C(Cl)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"SUZUKI,N AND MATSUO,T; J. FAC. ENG. UNIV. TOKYO, SER.B 42(4):307315, 1994; LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L;CHEM. RES. TOXICOL. 10(12):14271436, 1997; RAMOS,I LLOVERAS,M SOLANS,X HUICI,A AND MESSEGUER,A; ENVIRON. TOXICOL. CHEM. 19(11):26312636, 2000"
132059-53-1	3-bromo-4-(dibromomethyl)-5-hydroxy-2(5h)-furanone	OC1C(C(Br)Br)=C(Br)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"SUZUKI,N AND MATSUO,T; J. FAC. ENG. UNIV. TOKYO, SER.B 42(4):307315, 1994; LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L;CHEM. RES. TOXICOL. 10(12):14271436, 1997; RAMOS,I LLOVERAS,M SOLANS,X HUICI,A AND MESSEGUER,A; ENVIRON. TOXICOL. CHEM. 19(11):26312636, 2000"
149418-41-7	"3,4-dibromo-2(5h)-furanone"	O=C1C(Br)=C(Br)CO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT AND LEO,HR; CHEM. RES. TOXICOL. 7(6):779783, 1994"
199536-62-4	3-bromo-4-(bromomethyl)-2(5h)-furanone	O=C1C(Br)=C(CBr)CO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L;CHEM. RES. TOXICOL. 10(12):14271436, 1997"
199536-64-6	3-bromo-4-(bromomethyl)-5-hydroxy-2(5h)-furanone	OC1C(CBr)=C(Br)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L;CHEM. RES. TOXICOL. 10(12):14271436, 1997"
199536-65-7	3-chloro-4-(bromomethyl)-2(5h)-furanone	O=C1C(Cl)=C(CBr)CO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L; CHEM. RES. TOXICOL. 10(12):14271436, 1997"
199536-79-3	3-bromo-4-(dibromomethyl)-2(5h)-furanone	O=C1C(Br)=C(C(Br)Br)CO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L; CHEM. RES. TOXICOL. 10(12):14271436, 1997"
199536-82-8	3-chloro-4-(dibromomethyl)-2(5h)-furanone	O=C1C(Cl)=C(C(Br)Br)CO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L; CHEM. RES. TOXICOL. 10(12):14271436, 1997"
199536-84-0	3-bromo-4-(chloromethyl)-2(5h)-furanone	O=C1C(Br)=C(CCl)CO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"LALONDE,RT, BU,L, HENWOOD,A, FIUMANO,J AND ZHANG,L; CHEM. RES. TOXICOL. 10(12):14271436, 1997"