CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 495-18-1 n-Hydroxybenzamide ONC(=O)c1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T AND MORTELMANS,K; ENVIRON. MOL. MUTAGEN. 19(SUPPL.21):2141, 1992 10335-79-2 N,N-Naphthaloylhydroxylamine ONC(=O)c1ccc2ccccc2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 63408-86-6 1H-Indole-2-carboxamide,_N-hydroxy- ONC(=O)C1=Cc2ccccc2N1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 106807-80-1 Acetamide, N-hydroxy-N-((methylamino) CC(=O)N(O)C(=O)NC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) LEE,MS. et al; MUTAT. RES. 172(3):199-209, 1986 69177-41-9 Bleomycin_bapp CCCCNCCCNCCCNC(=O)C1=CSC(C2=CSC(CCNC(=O)C(C(C)O)NC(=O)C(C)C(O)C(C)NC(=O)C(C(C3=CN=CN3)OC3C(OC4C(O)C(OC(N)=O)C(O)C(CO)O4)C(O)C(O)C(CO)O3)NC(=O)c3c(C)c(N)nc(C(CC(N)=O)NCC(N)C(N)=O)n3)=N2)=N1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 127-07-1 Hydroxyurea NC(=O)NO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 149573-80-8 (1-Nitroso-1h-imidazol-4-yl)acetohydroxamic acid ONC(=O)CC1=CN(N=O)C=N1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Danno, G., et. al.; A Mutagen From Histidine Reacted With Nitrite; J. Agric. Food Chem. 41(7):1090-1093, 1993 51-79-6 Ethyl carbamate; Urethane CCOC(N)=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 69839-83-4 3,4-Dihydroxybenzohydroxamic acid Oc1ccc(C(=O)NO)cc1O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MIADOKOVA,E, MACAKOVA,K, PODSTAVKOVA,S AND VLECK,D; GENOTOXIC PROPERTIES OF THE NEWLY SYNTHESIZED ANTINEOPLASTIC AGENTS AMIDOX, DIDOX AND TRIMIDOX; PHARMAZIE 52(7):540-544, 1997 11056-06-7 Bleomycin CC(C(O)C(C)C(=O)NC(C(C)O)C(=O)NCCC1=NC(C2=NC(C(=O)NCCCS{+}(C)C)=CS2)=CS1)NC(=O)C(C(C1=CN=CN1)OC1C(OC2C(O)C(OC(N)=O)C(O)C(CO)O2)C(O)C(O)C(CO)O1)NC(=O)c1c(C)c(N)nc(C(CC(N)=O)NCC(N)C(N)=O)n1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Anderson, D., Basaran, N., Blowers, S.D., Edwards, A.J., The effect of antioxidants on bleomycin treatment in in vitro and in vivo genotoxicity assays. Mutat. Res., 1995, 329(1), 37-47 598-55-0 Methyl Carbamate COC(N)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NCI/NTP CARCINOGENESIS TECHNICAL REPORT SERIES; NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM; U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, TR-328 Y87; BRAMS,A, BUCHET,JP, CRUTZEN-FAYT,MC, DE MEESTER,C, LAUWERYS,R AND LEONARD,A; TOXICOL. LETT. 38(1-2):123-133, 1987; ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T AND MORTELMANS,K; ENVIRON. MOL. MUTAGEN. 11(SUPPL.12):1-158, 1988