CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 95-70-5 2-Methyl-Benzene-1,4-Diamine Cc1cc(N)ccc1N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 100-14-1 P-Nitrobenzyl Chloride [O-][N+](=O)c1ccc(CCl)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 104-91-6 P-Quinone Monooxime; 4-Nitroso-Phenol Oc1ccc(N=O)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 139-94-6 Nithiazide CCNC(=O)Nc1ncc(s1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2243-61-0 1,4-Naphthalenediamine Nc1ccc(N)c2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2243-62-1 1,5-Naphthalenediamine Nc1cccc2c1cccc2N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 24554-26-5 N-[4-(5-Nitro-2-Furyl)-2-Thiazolyl]Formamide [O-][N+](=O)c1ccc(o1)-c1csc(NC=O)n1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 53-95-2 N-Hydroxy-2-Acetylaminofluorene CC(=O)N(O)c1ccc2c(Cc3ccccc-23)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 10125-76-5 4-Nitrosobiphenyl O=Nc1ccc(-c2ccccc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 6810-26-0 Hydroxylamine,N-4-Biphenylyl- ONc1ccc(-c2ccccc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 6610-08-8 Naphthalene,2-Nitroso- O=Nc1ccc2ccccc2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1694-20-8 Stilbene,4-Nitro-,(E)- [O-][N+](=O)c1ccc(C=Cc2ccccc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 613-47-8 Hydroxylamine,N-2-Naphthyl- ONc1ccc2ccccc2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 275795-16-9 1,1'-Biphenyl,3-(1,1-Dimethylethyl)-4-Nitroso- CC(C)(C)c1cc(-c2ccccc2)ccc1N=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 279242-09-0 1,1'-Biphenyl,4-Ethyl-4'-Nitro- CCc1ccc(cc1)-c1ccc(cc1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 279242-11-4 1,1'-Biphenyl,4-(1,1-Dimethylethyl)-4'-Nitro- CC(C)(C)c1ccc(cc1)-c1ccc(cc1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 279242-17-0 1,1'-Biphenyl,4-(1,1-Dimethylethyl)-4'-Nitroso- CC(C)(C)c1ccc(-c2ccc(N=O)cc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 389104-57-8 1-Isopropyl-2-Aminofluorene; 1-Isopropyl-9h-Fluoren-2-Ylamine CC(C)c1c2Cc3ccccc3-c2ccc1N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 345667-01-8 [1,1'-Biphenyl]-4-Amine,3-(1,1-Dimethylethyl)-N-Hydroxy- CC(C)(C)c1cc(-c2ccccc2)ccc1NO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 345667-02-9 [1,1'-Biphenyl]-4-Amine,4'-(1,1-Dimethylethyl)-N-Hydroxy- CC(C)(C)c1ccc(-c2ccc(NO)cc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 24325-70-0 Trans-4-Methyl-4'-Nitrostilbene Cc1ccc(C=Cc2ccc(cc2)[N+]([O-])=O)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 345667-60-9 Benzene,1-Ethyl-4-[(1e)-2-(4-Nitrophenyl)Ethenyl]- CCc1ccc(C=Cc2ccc(cc2)[N+]([O-])=O)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 602-60-8 9-Nitroanthracene [O-][N+](=O)c1c2ccccc2cc2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 86-57-7 1-Nitronaphthalene [O-][N+](=O)c1cccc2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 91-23-6 2-Nitroanisole; O-Nitroanisole COc1ccccc1[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 99-59-2 5-Nitro-O-Anisidine COc1ccc(cc1N)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 42397-64-8 1,6-Dinitropyrene [O-][N+](=O)c1ccc2ccc3c(ccc4ccc1c2c34)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 100-17-4 4-Nitroanisole COc1ccc(cc1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 128714-75-0 1,6-Dinitrobenzo(A)Pyrene [O-][N+](=O)c1ccc2ccc3c(c4ccccc4c4ccc1c2c34)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 128714-76-1 3,6-Dinitrobenzo(A)Pyrene [O-][N+](=O)c1ccc2ccc3c4ccccc4c(c4ccc1c2c34)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 100-27-6 P-Nitrophenethyl_Alcohol OCCc1ccc(cc1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 129117-54-0 1,4-Dimethyl-6-Methoxy-3-Aminocarbazole Cc1cc(N)c(C)c2c1Nc1ccc(OC)cc-21 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 88-73-3 1-Chloro-2-Nitrobenzene [O-][N+](=O)c1ccccc1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 99-30-9 2,6-Dichloro-4-Nitroaniline Nc1c(Cl)cc(cc1Cl)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1635-61-6 5-Chloro-2-Nitroaniline Nc1cc(Cl)ccc1[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 91575-28-9 N-Acetyl-4,4'-Methylenebis(2-Chloroaniline) CC(=O)Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 53-94-1 Hydroxylamine, N-fluoren-2-yl- ONc1ccc2c(Cc3ccccc-23)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 607-30-7 1-Naphthylhydroxylamine ONc1cccc2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 623-10-9 Benzenamine, N-hydroxy-4-methyl- (9CI) Cc1ccc(NO)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NOHMI,T, et al; MUTAT. RES. 136(3):159-168, 1984 3096-64-8 Hydroxylamine, N-(2,5-xylyl)- Cc1ccc(C)cc1NO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NOHMI,T. et al ; MUTAT. RES. 136(3):159-168, 1984 16169-17-8 (1,1'-Biphenyl)-2-amine, N-hydroxy- ONc1ccccc1-c1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) IOANNIDES,C. et al ,CARCINOGENESIS 10(8):1403-1407, 1989 21229-99-2 Hydroxylamine, N-(p-(phenylthio)phenyl)- ONc1ccc(Sc2ccccc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) JUNEJA,TR. Et al MUTAT. RES. 263(1):13-19, 1991 38246-95-6 N-Hydroxyphenetidine CCOc1ccc(NO)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NOHMI,T. et al ,CHEM. PHARM. BULL. 33(7):2877-2885; HAGIWARA,Y. et al MUTAT. RES. 291(3):171-180, 1993 39501-62-7 4-Hydroxylaminodiphenyl ether ONc1ccc(Oc2ccccc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GUPTA, RL. et al TOXICOL. LETT. 34(1):13-21, 1986; MIYAUCHI,M. et al CHEM.-BIOL. INTERACT. 51(1):49-62, 1984 43192-07-0 Hydroxylamine, N-(3,4-xylyl)- Cc1ccc(NO)cc1C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NOHMI,T. et al ; MUTAT. RES. 136(3):159-168, 1984 67274-52-6 N-Acetyl-4-nitrophenylhydroxylamine CC(=O)N(O)c1ccc(cc1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Corbett, Md. et. al. Carcinogenesis 6(5):727-732, 1985 70853-94-0 2,4-Dimethylphenylhydroxylamine Cc1ccc(NO)c(C)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NOHMI,T, et al MUTAT. RES. 136(3):159-168, 1984 95331-48-9 Acetamide, N-hydroxy-N-1-pyrenyl- CC(=O)N(O)c1ccc2ccc3cccc4ccc1c2c34 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, LM, Kohan, MJ, Claxton, LD and Lewtas, J;Mutagenicity of Derivatives and Metabolites of 1-Nitropyrene: Activation by Rat Liver S9 and Bacterial Enzymes; Mutat. Res. 138(2-3):113-125, 1984 115084-47-4 Benzenamine, 4-((4-amino-3-chlorophenyl)methyl)-2-chloro-N-hydroxy- Nc1ccc(Cc2ccc(NO)c(Cl)c2)cc1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) KUSLIKIS,BI. et al, MUTAGENESIS 6(1):19-24, 1991 130040-14-1 Acetamide, N-hydroxy-N-(4-(phenylthio) CC(=O)N(O)c1ccc(Sc2ccccc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) JUNEJA,TR. et al; MUTAT. RES. 263(1):13-19, 1991 172374-57-1 4-Acetamido-4'-hydroxylaminodiphenyl ether CC(=O)Nc1ccc(Oc2ccc(NO)cc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GUPTA,RL. et al MUTAT. RES. 335(3):235-243, 1995 172374-58-2 N-(4-(4-(Acetylamino)phenoxy)phenyl)-N-hydroxyacetamide CC(=O)Nc1ccc(Oc2ccc(N(O)C(C)=O)cc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GUPTA,RL. et al MUTAT. RES. 335(3):235-243, 1995 89-61-2 2,5-dichloronitrobenzene [O-][N+](=O)c1cc(Cl)ccc1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU M.,YASUI Y., MATSUMOTO N., MUTAT.RES. 116:217-238,1983 99-54-7 3,4-Dichloronitrobenzene [O-][N+](=O)c1ccc(Cl)c(Cl)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 100-00-5 1-Chloro-4-nitrobenzene [O-][N+](=O)c1ccc(Cl)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU M.,YASUI Y., MATSUMOTO N., MUTAT.RES. 116:217-238,1983 350-30-1 Benzene, 2-chloro-1-fluoro-4-nitro- [O-][N+](=O)c1ccc(F)c(Cl)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU M.,YASUI Y., MATSUMOTO N., MUTAT.RES. 116:217-238,1983 350-46-9 1-Fluoro-4-nitrobenzene [O-][N+](=O)c1ccc(F)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU M.,YASUI Y., MATSUMOTO N., MUTAT.RES. 116:217-238,1983 364-74-9 2,5-Difluoronitrobenzene [O-][N+](=O)c1cc(F)ccc1F in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU M.,YASUI Y., MATSUMOTO N., MUTAT.RES. 116:217-238,1983 369-34-6 Benzene, 1,2-difluoro-4-nitro- [O-][N+](=O)c1ccc(F)c(F)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU M.,YASUI Y., MATSUMOTO N., MUTAT.RES. 116:217-238,1983 611-06-3 2,4-Dichloronitrobenzene [O-][N+](=O)c1ccc(Cl)cc1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU M.,YASUI Y., MATSUMOTO N., MUTAT.RES. 116:217-238,1983 17700-09-3 Benzene, 4-nitro-1,2,3-trichloro- [O-][N+](=O)c1ccc(Cl)c(Cl)c1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU M.,YASUI Y., MATSUMOTO N., MUTAT.RES. 116:217-238,1983 19881-18-6 Nitroscanate [O-][N+](=O)c1ccc(Oc2ccc(cc2)N=C=S)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 119-90-4 3,3'-Dimethoxybenzidine COc1cc(-c2ccc(N)c(OC)c2)ccc1N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) TAKAHASHI,A AND ONO,H; MUTAGENICITY ASSESSMENT IN 44 EPOXY RESIN HARDENERS IN SALMONELLA TYPHIMURIUM TESTER STRAINS; CHEM. EXPRESS 8(9):785-788, 1993 1211-40-1 4-Amino-4'-Nitrobiphenyl Nc1ccc(cc1)-c1ccc(cc1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SINSHEIMER,JE, HOOBERMAN,BH, DAS,SK, BREZZELL,MD AND YOU,Z; THE IN VIVO AND IN VITRO GENOTOXICITY OF AROMATIC AMINES IN RELATIONSHIP TO THE GENOTOXICITY OF BENZIDINE; MUTAT. RES. 268(2):255-264, 1992 3365-85-3 P,P'-Diaminoterphenyl Nc1ccc(-c2ccc(-c3ccc(N)cc3)cc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) WUEBBLES,BJY AND FELTON,JS; EVALUATION OF LASER DYE MUTAGENICITY USING THE AMES/ SALMONELLA MICROSOME TEST; ENVIRON. MUTAGEN. 7(4):511-522, 1985 448-97-5 3,3'-Difluorobenzidine Nc1ccc(-c2ccc(N)c(F)c2)cc1F in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SAVARD,S AND JOSEPHY,PD; SYNTHESIS AND MUTAGENICITY OF 3,3'-DIHALOGENATED BENZIDINES; CARCINOGENESIS 7(7):1239-1241, 1986 61841-39-2 3-Nitrobenzidine Nc1ccc(cc1)-c1ccc(N)c(c1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) YOU,Z, BREZZELL,MD, DAS,SK, ESPADAS-TORRE,MC, HOOBERMAN,BH AND SINSHEIMER,JE; ORTHO-SUBSTITUENT EFFECTS ON THE IN VITRO AND IN VIVO GENOTOXICITY OF BENZIDINE DERIVATIVES; MUTAT. RES. 319(1):19-30, 1993 63390-12-5 3,3',5-Trichlorobenzidine Nc1ccc(-c2cc(Cl)c(N)c(Cl)c2)cc1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) JOSEPHY,PD AND WILLIAMS,LL; UNAMBIGUOUS SYNTHESIS OF ASYMMETRICALLY SUBSTITUTED CHLORINATED BENZIDINES, AND A STUDY OF THEIR MUTAGENICITY IN THE AMES TEST. POTENT ACTIVITY OF 3,5,3'-TRICHLOROBENZIDINE; MUTAGENESIS 2(3):225-228, 1987 613-13-8 2-Anthracenamine Nc1ccc2cc3ccccc3cc2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Diehl, M. And Fort, F.; Spiral Salmonella Assay: Validation Against The Standard Pour-Plate Assay; Environ. Mol. Mutagen. 27(3):227-236, 1996 1606-67-3 1-Aminopyrene Nc1ccc2ccc3cccc4ccc1c2c34 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, LM, Kohan, MJ, Claxton, LD and Lewtas, J;Mutagenicity of Derivatives and Metabolites of 1-Nitropyrene: Activation by Rat Liver S9 and Bacterial Enzymes; Mutat. Res. 138(2-3):113-125, 1984 389104-56-7 Fluorene, 1-ethyl-2-amino- CCc1c2Cc3ccccc3-c2ccc1N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GLENDE,C. et al; TRANSFORMATION OF MUTAGENIC AROMATIC AMINES INTO NON-MUTAGENIC SPECIES BY ALKYL SUBSTITUENTS. PART I. ALKYLATION ORTHO TO THE AMINO FUNCTION. MUTAT. RES. 498(1-2):19-37, 2001 95-80-7 Toluene-2,4-diamine Cc1ccc(N)cc1N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) WATANABE,T. et al; STUDIES ON THE OXIDATION PRODUCTS FROM 2,4-DIAMINOTOLUENE BY HYDROGEN PEROXIDE AND THEIR MUTAGENICITIES. II, MUTAT. RES. 225(1-2):15-19, 1989 108-45-2 1,3-Benzenediamine Nc1cccc(N)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GENTILE,JM. Et al; MUTAGENICITY OF SELECTED ANILINE DERIVATIVES TO SALMONELLA FOLLOWING PLANT ACTIVATION AND MAMMALIAN HEPATIC ACTIVATION; MUTAT. RES. 188(3):185-196, 1987 139259-98-6 n-(acetyloxy)-n-[(4-nitrophenyl)methoxy]benzamide CC(=O)ON(OCc1ccc(cc1)[N+]([O-])=O)C(=O)c1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Bonin, Am., Banks, Tm., Campbell, Jj., Glover, Sa., Hammond, Gp., Prakash, As. and Rowbottom, Ca.; Mutagenicity Of Electrophilic N-Acyloxy-N-Alkoxyamides; Mutat. Res. 494(1-2):115-134, 2001 4637-56-3 4-Hydroxyaminoquinoline-1-oxide ONc1cc[n+](c2ccccc12)[O-] in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 61702-44-1 2-Chloro-p-phenylenediamine sulfate Nc1ccc(N)cc1Cl_OS(O)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2508-20-5 2-Nitrosofluorene O=Nc1ccc2c(Cc3ccccc-23)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1836-75-5 Nitrofen [O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 5131-60-2 4-Chloro-m-phenylenediamine Nc1ccc(Cl)c(N)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 389104-60-3 Biphenyl, 3-ethyl-4-amino- CCc1cc(-c2ccccc2)ccc1N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 612-83-9 3,3'-Dichlorobenzidine dihydrochloride Cl_Cl_Nc1ccc(-c2ccc(N)c(Cl)c2)cc1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 39156-41-7 2,4-Diaminoanisole sulfate COc1ccc(N)cc1N_OS(O)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 126485-28-7 6-Amino-3-[4-(4-Diethylaminophenylazo)-2-Methoxyphenylazo]-4-Hydroxy-2-Naphthylenesulfonic CCN(CC)c1ccc(N=NC2=CCC(N=Nc3c(S(O)(=O)=O)cc4ccc(N)cc4c3O)C(OC)=C2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 87-59-2 2,3-Xylidine Cc1cccc(N)c1C in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 89-63-4 4-Chloro-2-Nitroaniline Nc1ccc(Cl)cc1[N+]([O-])=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 90-04-0 O-Anisidine COc1ccccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 92-36-4 4-(6-Methyl-benzothiazol-2-yl)-phenylamine Cc1ccc2c(c1)SC(c1ccc(N)cc1)=N2 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Short-Term Testing Program in the National Cancer Institute (NCI), National Institutes of Health, US Department of Health and Human Services 92-67-1 4-Amino-1,1'-Biphenyl; Biphenyl-4-ylamine Nc1ccc(-c2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 93-05-0 N,N-Diethyl-P-Phenylenediamine CCN(CC)c1ccc(N)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-64-7 3,4-Xylidine Cc1ccc(N)cc1C in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-68-1 2,4-Dimethylaniline Cc1ccc(N)c(C)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-78-3 2,5-xylidine Cc1ccc(C)cc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-83-0 4-chloro-o-phenylenediamine Nc1ccc(Cl)cc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 99-98-9 N,N-Dimethyl-p-Phenylenediamine CN(C)c1ccc(N)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 100-65-2 n-Phenylhydroxylamine ONc1ccccc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 101-14-4 4,4'-Methylenebis(2-Chloroaniline) Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 101-77-9 4,4'-Methylene Dianaline Nc1ccc(Cc2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 101-80-4 4,4'-oxydianiline Nc1ccc(Oc2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 102-50-1 m-Cresidine Cc1cc(OC)ccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 104-94-9 p-Anisidine COc1ccc(N)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 106-47-8 P-Chloroaniline Nc1ccc(Cl)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 108-69-0 3,5-Xylidine Cc1cc(C)cc(N)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 117-18-0 2,3,5,6-Tetrachloronitrobenzene [O-][N+](=O)c1c(Cl)c(Cl)cc(Cl)c1Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 119-93-7 3,3'-Tolidine Cc1cc(-c2ccc(N)c(C)c2)ccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 120-71-8 p-Cresidine Cc1ccc(OC)c(N)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 134-32-7 1-Naphthylamine Nc1cccc2ccccc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 136-35-6 Diazoaminobenzene c1ccccc1NN=Nc1ccccc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 138-89-6 N,N-Dimethyl-p-Nitrosoaniline CN(C)c1ccc(N=O)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 139-65-1 4,4'-Thiodianiline Nc1ccc(Sc2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 156-10-5 p-Nitrosodiphenylamine O=Nc1ccc(Nc2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 156-43-4 p-Phenetidine CCOc1ccc(N)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 367-25-9 2,4-Difluoroaniline Nc1ccc(F)cc1F in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 493-52-7 C.I. Acid Red 2 CN(C)c1ccc(N=Nc2ccccc2C(O)=O)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 496-72-0 3,4-Diaminotoluene Cc1ccc(N)c(N)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 536-90-3 M-Anisidine COc1cccc(N)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 554-00-7 2,4-Dichloroaniline Nc1ccc(Cl)cc1Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 609-20-1 2,6-Dichloro-benzene-1,4-diamine Nc1cc(Cl)c(N)c(Cl)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 610-49-1 1-Anthracenamine Nc1cccc2cc3ccccc3cc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 881-03-8 1-Nitro-2-Methylnaphthalene Cc1ccc2ccccc2c1[N+]([O-])=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 2735-04-8 Aniline, 2,4-Dimethoxy- COc1ccc(N)c(OC)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 4309-66-4 4-Stilbenamine, (E)- Nc1ccc(C=Cc2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 7314-08-1 4-Stilbenamine, 4'-Methyl-, (E)- Cc1ccc(C=Cc2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 15121-84-3 O-Nitrophenethyl alcohol OCCc1ccccc1[N+]([O-])=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 15893-52-4 2H-1,4-Benzoxazin-3(4H)-one, 2,4-Dihydroxy-7-Methoxy- COc1ccc2c(c1)OC(O)C(=O)N2O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 16452-01-0 O-Cresidine Cc1ccc(N)cc1OC in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 19315-64-1 Acetohydroxamic acid, N-(4-Ethoxyphenyl)- CCOc1ccc(N(O)C(C)=O)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 20265-97-8 p-Anisidine hydrochloride COc1ccc(N{+}.Cl{-})cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 67219-70-9 1-Butyl-2-Aminonaphthalene; 1-Butyl-naphthalen-2-ylamine CCCCc1c2ccccc2ccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 69884-05-5 2h-1,4-Benzoxazin-3(4h)-One,4-Hydroxy-7-Methoxy COc1ccc2c(c1)OCC(=O)N2O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 74518-95-9 Benzene, 1-(1,1-Dimethylethyl)-4-[2-(4-Nitrophenyl)Ethenyl]-, (E)- CC(C)(C)c1ccc(C=Cc2ccc(cc2)[N+]([O-])=O)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 126335-31-7 Benzenamine,_4-((4-Amino-3-Methoxyphenyl)Azo)-N,N-Diethyl- CCN(CC)c1ccc(N=Nc2ccc(N)c(OC)c2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 127502-69-6 3-Isopropyl-4-Aminobiphenyl; 3-Isopropyl-biphenyl-4-ylamine CC(C)c1cc(-c2ccccc2)ccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 279242-10-3 1,1'-Biphenyl, 4-(1-Methylethyl)-4'-Nitro- CC(C)c1ccc(cc1)-c1ccc(cc1)[N+]([O-])=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 345667-57-4 Benzenamine, 4-[(1e)-2-(4-Ethylphenyl)Ethenyl]- CCc1ccc(C=Cc2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 345667-58-5 Benzenamine, 4-[(1e)-2-[4-(1-Methylethyl)Phenyl]Ethenyl]- CC(C)c1ccc(C=Cc2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 345667-59-6 Benzenamine, 4-[(1e)-2-[4-(1-Methylpropyl)Phenyl]Ethenyl]- CCC(C)c1ccc(C=Cc2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 345667-61-0 Stilbene, 4'-isopropyl-4-nitro-, trans- CC(C)c1ccc(C=Cc2ccc(cc2)[N+]([O-])=O)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 389104-61-4 3-Butyl-biphenyl-4-ylamine; Biphenyl, 3-butyl-4-amino- CCCCc1cc(-c2ccccc2)ccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GLENDE,C. et al; TRANSFORMATION OF MUTAGENIC AROMATIC AMINES INTO NON-MUTAGENIC SPECIES BY ALKYL SUBSTITUENTS. PART I. ALKYLATION ORTHO TO THE AMINO FUNCTION. MUTAT. RES. 498(1-2):19-37, 2001 2508-23-8 N-Hydroxy-N-2-naphthalenylacetamide CC(=O)N(O)c1ccc2ccccc2c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) WANG,CY, LINSMAIER-BEDNAR,EM, LEE,MS AND KING,CM; MUTAGENICITIES OF N-ACYL-N-ARYLHYDROXYLAMINES FOR SALMONELLA; CHEM-BIOL. INTERACT. 67(3-4):215-223, 1988 4463-22-3 N-Hydroxy-4-acetylaminobiphenyl CC(=O)N(O)c1ccc(-c2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) WANG,CY, LINSMAIER-BEDNAR,EM, LEE,MS AND KING,CM; MUTAGENICITIES OF N-ACYL-N-ARYLHYDROXYLAMINES FOR SALMONELLA; CHEM-BIOL. INTERACT. 67(3-4):215-223, 1988 71708-92-4 Acetamide, N-hydroxy-N-(4-phenoxyphenyl)- CC(=O)N(O)c1ccc(Oc2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MIYAUCHI,M, ENDOH,Y AND UEMATSU,T; MUTAGENIC ACTIVITY OF THE AMIDO DERIVATIVES AND THEIR HYDROXAMIC ACIDS OF NITROBIPHENYL ETHERS; BULL. ENVIRON. CONTAM. TOXICOL. 55(3):446-452, 1995 98911-07-0 Acetamide, N-(4-(4-chlorophenoxy)phenyl)-N-hydroxy- CC(=O)N(O)c1ccc(Oc2ccc(Cl)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Miyauchi, M., Endoh, Y. and Uematsu, T.; Mutagenic activity of the amido derivatives and their hydroxamic acids of nitrobiphenyl ethers; Bull. Environ. Contam. Toxicol. 55(3):446-452, 1995 98911-08-1 Acetamide, N-(4-(2,4-dichlorophenoxy)phenyl)-N-hydroxy- CC(=O)N(O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MIYAUCHI,M, ENDOH,Y AND UEMATSU,T; MUTAGENIC ACTIVITY OF THE AMIDO DERIVATIVES AND THEIR HYDROXAMIC ACIDS OF NITROBIPHENYL ETHERS; BULL. ENVIRON. CONTAM. TOXICOL. 55(3):446-452, 1995 87-62-7 2,6-Xylidine Cc1cccc(C)c1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 99-88-7 Cumidine; 4-isopropylaniline; p-Isopropylaniline CC(C)c1ccc(N)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 91-95-2 3,3'-Diaminobenzidine Nc1ccc(-c2ccc(N)c(N)c2)cc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Chung,K. et al; Mutagenicity Studies Of Benzidine And Its Analogs: Structure-Activity Relationships; Toxicol. Sci. 56(2):351-356, 2000; Messerly, Ea. et al; Structure-Mutagenicity Relationship Of Benzidine Analogues; Environ. Mol. Mutagen. 10:263-274, 1987 1204-41-7 4-Biphenylamine, 2'-methyl- Cc1ccccc1-c1ccc(N)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SINSHEIMER,JE. Et al; THE IN VIVO AND IN VITRO GENOTOXICITY OF AROMATIC AMINES IN RELATIONSHIP TO THE GENOTOXICITY OF BENZIDINE; MUTAT. RES. 268(2):255-264, 1992 3366-61-8 N-Acetylbenzidine CC(=O)Nc1ccc(-c2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MAKENA,PS AND CHUNGK-T; EVIDENCE THAT 4-AMINOBIPHENYL, BENZIDINE, AND BENZIDINE CONGENERS PRODUCE GENOTOXICITY THROUGH REACTIVE OXYGEN SPECIES; ENVIRON. MOL. MUTAGEN. 48(5):404-413, 2007 531-85-1 Benzidine dihydrochloride Cl_Cl_Nc1ccc(-c2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 553-30-0 Proflavine sulfate Nc1ccc2cc3ccc(N)cc3nc2c1_OS(O)(=O)=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 540-23-8 p-Toluidine hydrochloride Cc1ccc(N)cc1_Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 6109-97-3 Carbazole, 3-amino-9-ethyl-, hydrochloride CCN1c2ccccc2-c2cc(N{+}.Cl{-})ccc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 15481-70-6 Toluene-2,6-diamine, dihydrochloride Cc1c(N)cccc1N_Cl_Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 3209-22-1 2,3-Dichloronitrobenzene [O-][N+](=O)c1cccc(Cl)c1Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 843-23-2 Acetohydroxamic acid, trans-N-(p-styrylphenyl)- CC(=O)N(O)c1ccc(/C=C\c2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) WANG,CY, LINSMAIER-BEDNAR,EM, LEE,MS AND KING,CM; MUTAGENICITIES OF N-ACYL-N-ARYLHYDROXYLAMINES FOR SALMONELLA; CHEM-BIOL. INTERACT. 67(3-4):215-223, 1988 135-68-2 4-Amino-4'-chlorodiphenyl Nc1ccc(-c2ccc(Cl)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Sinsheimer,JE, Hooberman,BH, DAS,SK, BREZZELL,MD AND YOU,Z; THE IN VIVO AND IN VITRO GENOTOXICITY OF AROMATIC AMINES IN RELATIONSHIP TO THE GENOTOXICITY OF BENZIDINE; MUTAT. RES. 268(2):255-264, 1992 7570-36-7 4-amino-4'-chlorostilbene Nc1ccc(C=Cc2ccc(Cl)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) You,Z, Brezzell,MD, Das,SK, HOOBERMAN,BH AND SINSHEIMER,JE; SUBSTITUENT EFFECTS ON THE IN VITRO AND IN VIVO GENOTOXICITY OF 4-AMINOBIPHENYL AND 4-AMINOSTILBENE DERIVATIVES; MUTAT. RES. 320(1-2):45-58, 1994 67730-10-3 2-aminodipyrido[1,2-a:3',2'-d]imidazole Nc1ccc2c(n1)N1C=CC=CC1=N2 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) N'Goy, K., Saint-Ruf, G., de Meester, C., Mutagenicity of Some Derivatives of Dipyrido[1,2-a:3',2'-d]Imidazoles in Salmonella typhimurium with Metabolic Activation by Rat Liver and Small Intestine Subcellular Fractions. Mutat. Res., 1985, 156(1-2), 53 - 59 38514-71-5 anft;2-amino-4-(5-nitro-2-furyl)thiazole Nc1nc(cs1)-c1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215 7297-52-1 (e)-4-amino-4'-nitrostilbene Nc1ccc(C=Cc2ccc(cc2)[N+](=O)[O-])cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HOOBERMAN,BH, BREZZELL,MD, DAS,SK, YOU,Z AND SINSHEIMER,JE; SUBSTITUENT EFFECTS ON THE GENOTOXICITY OF 4-NITROSTILBENE DERIVATIVES; MUTAT. RES. 341(1): 57-69, 1994 92-87-5 benzidine;biphenyl-4,4'-diamine Nc1ccc(-c2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MESSERLY,EA, FEKETE,JE, WADE,DR AND SINSHEIMER,JE; STRUCTURE-MUTAGENICITY RELATIONSHIP OF BENZIDINE ANALOGUES; ENVIRON. MOL. MUTAGEN. 10:263-274, 1987; SINSHEIMER,JE, HOOBERMAN,BH, DAS,SK, BREZZELL,MD AND YOU,Z; THE IN VIVO AND IN VITRO GENOTOXICITY OF AROMATIC AMINES IN RELATIONSHIP TO THE GENOTOXICITY OF BENZIDINE; MUTAT. RES. 268(2):255-264, 1992 14064-55-2 4-chloro-4'-nitrostilbene [O-][N+](=O)c1ccc(C=Cc2ccc(Cl)cc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HOOBERMAN,BH, BREZZELL,MD, DAS,SK, YOU,Z AND SINSHEIMER,JE; SUBSTITUENT EFFECTS ON THE GENOTOXICITY OF 4-NITROSTILBENE DERIVATIVES; MUTAT. RES. 341(1): 57-69, 1994 159394-71-5 (e)-3-cyano-4'-nitrostilbene [O-][N+](=O)c1ccc(C=Cc2cccc(c2)C#N)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HOOBERMAN,BH, BREZZELL,MD, DAS,SK, YOU,Z AND SINSHEIMER,JE; SUBSTITUENT EFFECTS ON THE GENOTOXICITY OF 4-NITROSTILBENE DERIVATIVES; MUTAT. RES. 341(1): 57-69, 1994 74518-94-8 trans-4'-tert-butyl-4-nitrostilbene [O-][N+](=O)c1ccc(C=Cc2ccc(cc2)C#N)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HOOBERMAN,BH, BREZZELL,MD, DAS,SK, YOU,Z AND SINSHEIMER,JE; SUBSTITUENT EFFECTS ON THE GENOTOXICITY OF 4-NITROSTILBENE DERIVATIVES; MUTAT. RES. 341(1): 57-69, 1994 621-96-5 4,4'-diaminostilbene Nc1ccc(C=Cc2ccc(N)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SINSHEIMER,JE, HOOBERMAN,BH, DAS,SK, BREZZELL,MD AND YOU,Z; THE IN VIVO AND IN VITRO GENOTOXICITY OF AROMATIC AMINES IN RELATIONSHIP TO THE GENOTOXICITY OF BENZIDINE; MUTAT. RES. 268(2):255-264, 1992 823-40-5 2,6-diaminotoluene Cc1c(N)cccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SAYAMA,M, MORI,M, SHIROKAWA,T, INOUE,M, MIYAHARA,T AND KOZUKA,H; MUTAGENICITY OF 2,6-DINITROTOLUENE AND ITS METABOLITES, AND THEIR RELATED COMPOUNDS IN SALMONELLA TYPHIMURIUM; MUTAT. RES. 226(3):181-184, 1989 34237-98-4 3,3'-dibromobenzidine Nc1ccc(-c2ccc(N)c(Br)c2)cc1Br in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SAVARD,S AND JOSEPHY,PD; SYNTHESIS AND MUTAGENICITY OF 3,3'-DIHALOGENATED BENZIDINES; CARCINOGENESIS 7(7):1239-1241, 1986 91-94-1 3,3'-dichlorobenzidine; [1,1'-biphenyl]-4,4'-diamine, 3,3'-dichloro- Nc1ccc(-c2ccc(N)c(Cl)c2)cc1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GARNER,RC, WALPOLE,AL AND ROSE,FL; TESTING OF SOME BENZIDINE ANALOGUES FOR MICROSOMAL ACTIVATION TO BACTERIAL MUTAGENS; CANCER LETT. 1:39-42, 1975][COMMONER,B; RELIABILITY OF BACTERIAL MUTAGENESIS TECHNIQUES TO DISTINGUISH CARCINOGENIC AND NONCARCINOGENIC CHEMICALS;NTIS PB-259934, EPA-600/1-76-022, 1976 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(N=Nc2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T, MORTELMANS,K AND SPECK,W; SALMONELLA MUTAGENICITY TESTS: III. RESULTS FROM THE TESTING OF 255 CHEMICALS; ENVIRON. MOL. MUTAGEN. 9(SUPPL.9):1-110, 1987 607-59-0 Aniline, N,N-dimethyl-p-(1-naphthylazo)- CN(C)c1ccc(N=Nc2cccc3ccccc23)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHORT-TERM TEST PROGRAM SPONSORED BY THE DIVISION OF CANCER BIOLOGY, NATIONAL CANCER INSTITUTE, MS. ELLEN ZAIKA, ASSISTANT PROJECT OFFICER , p. Y82 19622-55-0 cl 64855 Cn1c(ncc1[N+]([O-])=O)-c1nnc(N)s1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) FERREIRA,RCC AND FERREIRA,LCS; MUTAGENICITY OF CL 64855, A POTENT ANTI-TRYPANOSOMA CRUZI DRUG; MUTAT. RES. 171(1):11-15, 1986 4648-33-3 4-methoxy-4'-nitrostilbene;er u1380 COc1ccc(C=Cc2ccc(cc2)[N+]([O-])=O)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HOOBERMAN,BH, BREZZELL,MD, DAS,SK, YOU,Z AND SINSHEIMER,JE; SUBSTITUENT EFFECTS ON THE GENOTOXICITY OF 4-NITROSTILBENE DERIVATIVES; MUTAT. RES. 341(1): 57-69, 1994 91-59-8 2-naphthylamine Nc1ccc2ccccc2c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) JORDAN,VC, LABABIDI,MK AND LANGAN-FAHEY,S; SUPPRESSION OF MOUSE MAMMARY TUMORIGENESIS BY LONG-TERM TAMOXIFEN THERAPY; J. NATL. CANCER INST. 83:492-496, 1991 7496-02-8 6-nitrochrysene c1(cc2c3ccccc3ccc2c2ccccc12)[N+](=O)[O-] in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) EL-BAYOUMY,K, DELCLOS,KB, HEFLICH,RH, WALKER,R, SHIUE,GH AND HECHT,SS; MUTAGENICITY, METABOLISM AND DNA ADDUCT FORMATION OF 6-NITROCHRYSENE IN SALMONELLA TYPHIMURIUM; MUTAGENESIS 4(3):235-240, 1989 2578-75-8 n-(5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl)acetamide CC(=O)Nc1nnc(s1)-c1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 531-82-8 n-(4-(5-nitro-2-furyl)-2-thiazolyl)acetamide CC(=O)Nc1nc(cs1)-c1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215 581-89-5 2-nitronaphthalene;2nitronaphthalene [O-][N+](=O)c1ccc2ccccc2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MCCANN,J, CHOI,E, YAMASAKI,E AND AMES,BN; DETECTION OF CARCINOGENS AS MUTAGENS IN THE SALMONELLA/MICROSOME TEST: ASSAY OF 300 CHEMICALS; PROC. NATL. ACAD. SCI. USA 72(12):5135-5139, 1975 5522-43-0 1-nitropyrene;pyrene, 1-nitro- [O-][N+](=O)c1ccc2ccc3cccc4ccc1c2c34 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) EL-BAYOUMY,K AND HECHT,SS; MUTAGENICITY OF K-REGION DERIVATIVES OF 1-NITROPYRENE; REMARKABLE ACTIVITY OF 1- AND 3-NITRO-5H-PHENANTHRO[4,5-BCD]PYRAN-5-ONE; MUTAT. RES. 170(1-2):31-40, 1986 13024-49-2 4-(2-phenylethyl)aniline Nc1ccc(CCc2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SINSHEIMER,JE, HOOBERMAN,BH, DAS,SK, BREZZELL,MD AND YOU,Z; THE IN VIVO AND IN VITRO GENOTOXICITY OF AROMATIC AMINES IN RELATIONSHIP TO THE GENOTOXICITY OF BENZIDINE; MUTAT. RES. 268(2):255-264, 1992 8048-52-0 Acriflavine Cn{+}1(.Cl{-})c2cc(N)ccc2cc2ccc(N)cc12_Nc1ccc2cc3ccc(N)cc3nc2c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Brown, Jp. and Brown, Rj.; Mutagenesis by 9,10-Anthraquinone Derivatives and Related Compounds in Salmonella Typhimurium; Mutat. Res. 40:203-224, 1976 95-53-4 2-methylaniline;2-toluidine;toluidine Cc1ccccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hamzah,Ry and El-Torkey,Nm; MUTAGENIC ACTIVITIES OF AROMATIC AMINES IN SALMONELLA TYPHIMURIUM AND ITS EFFECT ON RAT DRUG METABOLIZING ENZYMES; ARAB GULF J. SCI. RES. 13(1):13-23, 1995 2243-78-9 2-nitrobenzidine Nc1ccc(cc1)-c1ccc(N)cc1[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) You,Z, Brezzell,Md, Das,Sk, ESPADAS-TORRE,MC, HOOBERMAN,BH AND SINSHEIMER,JE; ORTHO-SUBSTITUENT EFFECTS ON THE IN VITRO AND IN VIVO GENOTOXICITY OF BENZIDINE DERIVATIVES; MUTAT. RES. 319(1):19-30, 1993 67730-11-4 2-Amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole CC1=CC=CN2C1=Nc1ccc(N)nc21 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Peters, J.H., Mortelmans, K.E., Reist, E.J., Sigman, C.C., Spanggord, R.J., Thomas, D.W., Synthesis, Chemical Characterization, and Mutagenic Activities of Promutagens Produced by Pyrolysis of Proteinaceous Substances. Environ. Mutagen., 1981, 3(6), 639 ? 649 4003-94-5 4-nitrostilbene [O-][N+](=O)c1ccc(C=Cc2ccccc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MULLEN,CA, RASHID,KA AND MUMMA,RO; MUTAGENIC POTENCY OF SOME CONJUGATED NITROAROMATIC COMPOUNDS AND ITS RELATIONSHIP TO STRUCTURE; MUTAT. RES. 188(4): 267-274, 1987 88-05-1 2,4,6-trimethylaniline Cc1cc(C)cc(C)c1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIMIZU,H AND TAKEMURA,N; MUTAGENICITY OF SOME ANILINE DERIVATIVES; OCCUP. HEALTH CHEM. IND., PROC. INT. CONGR., 11TH:497-506, 1983 547-58-0 methyl orange; sodium; 4-(4-dimethylamino-phenylazo)-benzenesulfonate; benzenesulfonic acid, 4-[[4-(dimethylamino)phenyl]azo]-, sodium salt CN(C)c1ccc(N=Nc2ccc(S(=O)(=O)O{-}.[Na]{+})cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ben Mansour, H., Barillier, D., Corroler, D., Ghedira, K., Chekir-Ghedira, L., Mosrati, R., In vitro study of DNA damage induced by acid orange 52 and its biodegradation derivatives. Environ. Toxicol. Chem., 2009, 28(3), 489-495. 62-53-3 Aniline Nc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-82-9 2,5-Dichloroaniline Nc1cc(Cl)ccc1Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 99-08-1 3-Nitrotoluene Cc1cccc(c1)[N+](=O)[O-] in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 103-69-5 N-Ethylaniline CCNc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 108-44-1 3-Aminotoluene Cc1cccc(N)c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 2438-88-2 2,3,5,6-Tetrachloro-4-Nitroanisole COc1c(Cl)c(Cl)c(c(Cl)c1Cl)[N+]([O-])=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory