CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 126-99-8 2-Cloro-1,3-butadiene; Chloroprene C=CC(=C)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) https://echa.europa.eu/registration-dossier/-/registered-dossier/15226/7/7/2 484-20-8 5-Methoxypsoralen COc1c2C=CC(=O)Oc2cc2c1C=CO2 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) D. Kirkland, L. Reeve, D. Gatehouse, P. Vanparys, A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins, Mutat. Res. 721 (2011) 27-73. 79-27-6 1,1,2,2-Tetrabromoethane BrC(Br)C(Br)Br in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Strubel, K., T. Grummt, Aliphatic and Aromatic Halocarbons as Potential Mutagens in Drinking Water. III. Halogenated Ethanes and Ethenes, Toxicol. Environ. Chem. 15(1-2) (1987), 101 û 128 286-20-4 1,2-Epoxycyclohexane; 7-Oxa-bicyclo[4.1.0]heptane C1CCCC2C1O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Short-Term Testing Program in the National Cancer Institute (NCI), National Institutes of Health, US Department of Health and Human Services 78-87-5 1,2-Dichloro-propane CC(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 564-00-1 Butane, meso-1,2:3,4-diepoxy C1C(C2CO2)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 106-87-6 1-Ethyleneoxy-3,4-epoxycyclohexane C1CC(C2CO2)CC2C1O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 106-93-4 1,2-Dibromaethane BrCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1072-52-2 1-Aziridine ethanol OCCN1CC1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 114-83-0 1-Acetyl-2-phenylhydrazine CC(=O)NNc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 19686-73-8 1-Bromo-2-propanol CC(O)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 24554-26-5 N-(4-(5-Nitro-2-furyl)-2-thiazolyl)formamide [O-][N+](=O)c1ccc(o1)-c1csc(NC=O)n1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 3688-53-7 2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide NC(=O)C(=Cc1ccc(o1)[N+]([O-])=O)c1ccco1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 503-09-3 1,2-Epoxy-3-fluoropropane FCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 52-24-4 Thiotepa S=P(N1CC1)(N1CC1)N1CC1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 540-51-2 2-Bromo-1-ethanol OCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 542-75-6 1-Propene, 1,3-dichloro ClCC=CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 16238-56-5 7-Bromomethyl-12-methylbenzanthracene Cc1c2ccccc2c(CBr)c2ccc3ccccc3c12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 5493-45-8 1,2-Cyclohexanedicarboxylic acid, bis(oxiranylmethyl) ester O=C(C1CCCCC1C(=O)OCC1CO1)OCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 616-23-9 2,3-Dichloropropan-1-ol OCC(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 62-73-7 Dichlorvos COP(=O)(OC)OC=C(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 623-17-6 Furfuryl acetate CC(=O)OCC1=CC=CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 627-18-9 3-Bromo-1-propanol OCCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 75-55-8 Propyleneimine CC1CN1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 765-34-4 Glycidaldehyde O=CC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 78-88-6 2,3-Dichloro-1-propene C=C(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 96-09-3 Styrene-7,8-oxide C1C(c2ccccc2)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 96-13-9 2,3-Dibromo-1-propanol OCC(Br)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 98-87-3 alpha,alpha-Dichlorotoluene ClC(Cl)c1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 42397-64-8 1,6-Dinitropyrene [O-][N+](=O)c1ccc2ccc3c(ccc4ccc1c2c34)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 42397-65-9 1,8-Dinitropyrene [O-][N+](=O)c1ccc2ccc3ccc(c4ccc1c2c34)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1675-54-3 Bisphenol A diglycidyl ether CC(C)(c1ccc(OCC2CO2)cc1)c1ccc(OCC2CO2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 57-97-6 7,12-Dimethylbenz(a)anthracene Cc1c2ccccc2c(C)c2ccc3ccccc3c12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 7166-19-0 beta-Bromo-beta-nitrostyrene [O-][N+](=O)C(Br)=Cc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 7195-43-9 Isophthalic diglycidyl ester O=C(c1cccc(C(=O)OCC2CO2)c1)OCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 16529-56-9 2-Methyl-3-butenenitrile CC(C=C)C#N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 76002-91-0 3-(4-(1-(4-(2,3-Epoxypropoxy)phenyl)-1-methylethyl)phenoxy)propane-1,2-diol CC(C)(c1ccc(OCC(O)CO)cc1)c1ccc(OCC2CO2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 100-63-0 Phenylhydrazine NNc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 95331-48-9 Acetamide, N-hydroxy-N-1-pyrenyl- CC(=O)N(O)c1ccc2ccc3cccc4ccc1c2c34 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, LM, Kohan, MJ, Claxton, LD and Lewtas, J;Mutagenicity of Derivatives and Metabolites of 1-Nitropyrene: Activation by Rat Liver S9 and Bacterial Enzymes; Mutat. Res. 138(2-3):113-125, 1984 16-6 COc1cc(C{P-}2C{P-}3C{P+}(COC3=O)C{P+}(OC{P-}3C{P-}(O)C{P-}(O)C{P-}4C{P-}(COC{P-}(C5=CC=CS5)O4)O3)c3cc4c(cc23)OCO4)cc(OC)c1O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199 584-48-5 1-bromo-2,4-dinitrobenzene [O-][N+](=O)c1ccc(Br)c(c1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55965-84-9 Kathon 886 CN1C(=O)C=C(Cl)S1_CN1C(=O)C=CS1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Connor, TH., Tee, PG., Afshar, M. and Connor, KM.; Mutagenicity of Cosmetic Products Containing Kathon; Environ. Mol. Mutagen. 28(2):127-132, 1996 144425-09-2 9-Methoxytariacuripyrone COc1ccc2cc(c3C=CC(=O)Oc3c2c1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Schimmer, O. and Drewello,U; 9-Methoxytariacuripyrone, a Naturally Occurring Nitro-Aromatic Compound with Strong Mutagenicity in Salmonella Typhimurium; Mutagenesis 9(6):547-551, 1994 13164-04-0 Chalepin CC(C)(C=C)C1=Cc2cc3CC(C(C)(C)O)Oc3cc2OC1=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 6-02-1 ICR 370 ClCCNCCCNc1c2ccccc2nc2c1ccc1ccccc21 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199 6-02-2 ICR 292 CCN(CCCNc1c2ccccc2nc2c1ccc1ccccc21)CCCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199 7470-44-2 Benzene, 4-(2,3-epoxypropyl)-1,2-(methylenedioxy)- C1C(Cc2ccc3c(c2)OCO3)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 106-91-2 2-propenoic acid, 2-methyl-, oxiranylmethyl ester CC(=C)C(=O)OCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 109-70-6 1-bromo-3-chloropropane ClCCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 613-13-8 2-Anthracenamine Nc1ccc2cc3ccccc3cc2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Diehl, M. And Fort, F.; Spiral Salmonella Assay: Validation Against The Standard Pour-Plate Assay; Environ. Mol. Mutagen. 27(3):227-236, 1996 1606-67-3 1-Aminopyrene Nc1ccc2ccc3cccc4ccc1c2c34 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, LM, Kohan, MJ, Claxton, LD and Lewtas, J;Mutagenicity of Derivatives and Metabolites of 1-Nitropyrene: Activation by Rat Liver S9 and Bacterial Enzymes; Mutat. Res. 138(2-3):113-125, 1984 115-07-1 Propylene CC=C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Tox. Program, Study ID: 779144 (Positive - 1989). 107027-12-3 n-[2-(dimethylamino)ethyl]-2-phenyl-8-quinolinecarboxamide CN(C)CCNC(=O)c1cccc2ccc(-c3ccccc3)nc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 131862-17-4 n-[2-(dimethylamino)ethyl]benzo[f]quinoline-5-carboxamide CN(C)CCNC(=O)c1cc2ccccc2c2cccnc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 131862-22-1 n-[2-(dimethylamino)ethyl]-2-phenyl-7-benzofurancarboxamide CN(C)CCNC(=O)c1cccc2C=C(c3ccccc3)Oc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 10048-13-2 Sterigmatocystin COc1cc2c(C3C=COC3O2)c2c1C(=O)c1c(cccc1O)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-53-6 Austocystin d CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(c(O)c1C2=O)C1(O)C=COC1O3 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) KFIR,R, JOHANNSEN,E AND VLEGGAAR,R; BULL. ENVIRON. CONTAM. TOXICOL. 37(5):643650, 1986 55256-55-8 austocystin c CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(C4C=COC4O3)c(OC)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-57-0 austocystin b CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(C4C=COC4O3)c(O)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-58-1 Austocystin A COc1c(Cl)ccc2c1C(=O)c1c(cc3c(C4C=COC4O3)c1OC)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 58775-50-1 austocystin h CC(C)=CCc1ccc(O)c2c1Oc1cc3c(c(O)c1C2=O)C1(O)C=COC1O3 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) KFIR,R, JOHANNSEN,E AND VLEGGAAR,R; BULL. ENVIRON. CONTAM. TOXICOL. 37(5):643650, 1986 77996-03-3 rutacridone epoxide CC1(C2Cc3c(cc(O)c4c3N(C)c3ccccc3C4=O)O2)CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 87619-82-7 s-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine NC(CSC(Cl)=C(Cl)C(Cl)=C(Cl)Cl)C(O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 131229-63-5 n-(acetyloxy)-n-butoxy-4-bromobenzamide CCCCON(C(=O)c1ccc(Br)cc1)OC(C)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Bonin, Am., Banks, Tm., Campbell, Jj., Glover, Sa., Hammond, Gp., Prakash, As. and Rowbottom, Ca.; Mutagenicity Of Electrophilic N-Acyloxy-N-Alkoxyamides; Mutat. Res. 494(1-2):115-134, 2001 139259-97-5 n-(acetyloxy)-n-[(4-bromophenyl)methoxy]benzamide CC(=O)ON(C(=O)c1ccccc1)OCc1ccc(Br)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Bonin, Am., Banks, Tm., Campbell, Jj., Glover, Sa., Hammond, Gp., Prakash, As. and Rowbottom, Ca.; Mutagenicity Of Electrophilic N-Acyloxy-N-Alkoxyamides; Mutat. Res. 494(1-2):115-134, 2001 484-47-9 2,4,5-triphenylimidazole;1h-imidazole, 2,4,5-triphenyl-;2,4,5-triphenyl-1h-imidazole c1ccccc1C1=C(c2ccccc2)NC(c2ccccc2)=N1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1728-95-6 2-(4-methoxyphenyl)-4,5-diphenyl-1h-imidazole;ccris 8669 COc1ccc(C2NC(c3ccccc3)=C(c3ccccc3)N=2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 5496-41-3 2-(3,4-dimethoxyphenyl)-4,5-diphenyl-1h-imidazole COc1ccc(C2NC(c3ccccc3)=C(c3ccccc3)N=2)cc1OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 107-02-8 Acrolein C=CC=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 75-21-8 Ethylene oxide C1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Agurell, E., et. al.; Genotoxic Effects of Ethylene Oxide and Propylene Oxide: A Comparative Study; Mutat. Res. 250(1-2):229-237, 1991; Rannug, U., Gothe, R. and Wachtmeister, Ca.; The Mutagenicity of Chloroethylene Oxide, Chloroacetaldehyde, 2-Chloroethanol and Chloroacetic Acid, Conceivable Metabolites of Vinyl Chloride; Chem. Biol. Interact. 12:251-263, 1976 4637-56-3 4-Hydroxyaminoquinoline-1-oxide ONc1cc[n+]([O-])c2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 6-02-6 ICR 312 ClCCNCCNc1c2ccccc2nc2c1ccc1ccccc21 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199 38915-49-0 2-Ethanediamine, N-benz(c)acridin-7-yl-N'-(2-chloroethyl)-, dihydrochloride, hydrate; ICR 312 Cl_Cl_ClCCNCCNc1c2ccccc2nc2c1ccc1ccccc21_O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 488-41-5 Mitobronitol OC{P+}(CBr)C{P-}(O)C{P+}(O)C{P+}(O)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 100-42-5 Styrene C=Cc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1629-58-9 1-Penten-3-one CCC(=O)C=C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Deininger, C., Eder, E., Neudecker, T. and Hoffman, C.; Mutagenicity and Genotoxicity of Ethyl Vinyl Ketone in Bacterial Tests; J. Appl. Toxicol. 10(3):167-171, 1990 79-01-6 Trichloroethylene ClC=C(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) STROBEL,K AND GRUMMT,T; ALIPHATIC AND AROMATIC HALOCARBONS AS POTENTIAL MUTAGENS IN DRINKING WATER. III. HALOGENATED ETHANES AND ETHENES; TOXICOL. ENVIRON. CHEM. 15(1-2):101-128, 1987 87-68-3 Hexachloro-1,3-butadiene ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 86-54-4 Hydralazine N/N=C1C{P+}2C=CC=CC2=CN=N/1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 482-44-0 Pentosalen CC(C)=CCOc1c2c(cc3C=CC(=O)Oc13)C=CO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Uwaifo, AO.; The Mutagenicities of Seven Coumarin Derivatives and a Furan Derivative (Nimbolide) Isolated from Three Medicinal Plants; J. Toxicol. Environ. Health 13(4-6):521-530, 1984 50-32-8 Benzo[a]pyrene c1cccc2cc3ccc4cccc5ccc(c12)c3c45 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Chemicals Evaluation and Research Institute, Japan 51-79-6 Ethyl carbamate; Urethane CCOC(N)=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 53-70-3 1,2:5,6-Dibenzanthracene; Dibenz(A,H)Anthracene c1cccc2ccc3cc4c5ccccc5ccc4cc3c12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 56-49-5 3-methylcholanthrene Cc1ccc2cc3c4ccccc4ccc3c3CCc1c23 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 78-94-4 Methyl Vinyl Ketone CC(=O)C=C in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 85-01-8 Phenanthrene c1cccc2ccc3ccccc3c12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 85-02-9 Benzo(f)quinoline c1cccc2ccc3c(cccn3)c12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 90-13-1 1-Chloronaphthalene Clc1cccc2ccccc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 91-62-3 6-Methylquinoline Cc1ccc2c(c1)cccn2 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-06-7 Sulfallate CCN(CC)C(=S)SCC(=C)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 96-18-4 1,2,3-Trichloropropane ClCC(Cl)CCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 109-64-8 1,3-Dibromopropane BrCCCBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 110-26-9 N,N'-Methylene-Bis-Acrylamide C=CC(=O)NCNC(=O)C=C in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 120-12-7 Anthracene c1cccc2cc3ccccc3cc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 129-00-0 Pyrene c1ccc2ccc3cccc4ccc1c2c34 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 136-35-6 Diazoaminobenzene c1ccccc1NN=Nc1ccccc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 192-97-2 Benzo[e]pyrene c1cccc2c1c1cccc3ccc4cccc2c4c13 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Chemicals Evaluation and Research Institute, Japan 205-99-2 Benzo(b)fluoranthene c1cccc2cc3c4ccccc4c4cccc(c12)c34 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 207-08-9 Benzo(k)fluoranthene; PL-106995 c1cccc2cc3c4cccc5cccc(c3cc12)c45 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 610-49-1 1-Anthracenamine Nc1cccc2cc3ccccc3cc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1126-61-0 1,2-Benzenediol,_4-(2-propenyl)- C=CCc1ccc(O)c(O)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 2461-15-6 2-Ethylhexyl Glycidyl Ether CCCCC(CC)COCC1CO1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 4080-31-3 N-(3-Chloroallyl) Hexaminium Chloride ClC=CCN{+}12(.Cl{-})CN3CN(C1)CN(C2)C3 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 13366-73-9 Photodieldrin ClC1C2(Cl)C3C4C5C(C3C3C4C1(Cl)C(Cl)(Cl)C23Cl)O5 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1192-62-7 2-Acetylfuran CC(=O)C1=CC=CO1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHINOHARA,K, KIM, EH AND OMURA,H; FURANS AS THE MUTAGENS FORMED BY AMINO-CARBONYL REACTIONS; DEV. FOOD SCI. 13(AMINO-CARBONYL REACT. FOOD BIOL. SYST.):353-362, 1986 121-39-1 Ethyl 3-phenylglycidate CCOC(=O)C1C(c2ccccc2)O1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) TILCH,C AND ELIAS,PS; INVESTIGATION OF THE MUTAGENICITY OF ETHYL PHENYLGLYCIDATE; MUTAT. RES. 138(1):1-8, 1984 75-35-4 1,1-Dichloroethylene C=C(Cl)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) STROBEL,K AND GRUMMT,T; ALIPHATIC AND AROMATIC HALOCARBONS AS POTENTIAL MUTAGENS IN DRINKING WATER. III. HALOGENATED ETHANES AND ETHENES; TOXICOL. ENVIRON. CHEM. 15(1-2):101-128, 1987; GOTO,S, SHIRAISHI,F, TANABE,K, ENDO,O, MACHII,K, TEZUKA,Y, ISHII,T AND MATSUSHITA,H; MUTAGENICITY DETECTION METHOD FOR VINYL CHLORIDE AND VINYLIDENE CHLORIDE GASES; KANKYO KAGAKU 5(2):235-240, 1995 127-18-4 Tetrachloroethylene ClC(Cl)=C(Cl)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) VAMVAKAS,S, et. al.; MUTAGENICITY OF TETRACHLOROETHENE IN THE AMES TEST-METABOLIC ACTIVATION BY CONJUGATION WITH GLUTATHIONE; J. BIOCHEM. TOXICOL. 4(1):21-27, 1989; SHIMADA,T, et. al.; ACTIVITIES OF CHLORINATED ETHANE AND ETHYLENE COMPOUNDS IN THE SALMONELLA/RAT MICROSOME MUTAGENESIS AND RAT HEPATOCYTE/DNA REPAIR ASSAYS UNDER VAPOR PHASE EXPOSURE CONDITIONS; CELL BIOL. TOXICOL. 1(3):159-179, 1985 91-22-5 Quinoline c1cccc2cccnc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) TAKAHASHI,A AND ONO,H; MUTAGENICITY ASSESSMENT IN 44 EPOXY RESIN HARDENERS IN SALMONELLA TYPHIMURIUM TESTER STRAINS; CHEM. EXPRESS 8(9):785-788, 1993; HASHIMOTO,T, NEGISHI,T, NAMBA,T, HAYAKAWA,S AND HAYATSU,H; MUTAGENICITY OF QUINOLINE DERIVATIVES AND ANALOGS - QUINOXALINE 1,4-DIOXIDE IS A POTENT MUTAGEN; CHEM. PHARM. BULL. 27(8):1954-1956, 1979 298-81-7 Methoxalen COc1c2c(cc3C=CC(=O)Oc13)C=CO2 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NCI/NTP CARCINOGENESIS TECHNICAL REPORT SERIES; U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, TR-359 Y89 91-64-5 Coumarin O=C1C=Cc2ccccc2O1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NCI/NTP CARCINOGENESIS TECHNICAL REPORT SERIES; NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM; U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, TR-422 Y93; GEE,P, SOMMERS,CH, MELICK,AS, GIDROL,XM, TODD,MD, BURRIS,RB, NELSON,ME, KLEMM,RC AND ZEIGER,E; COMPARISON OF RESPONSES OF BASE-SPECIFIC SALMONELLA TESTER STRAINS WITH THE TRADITIONAL STRAINS FOR IDENTIFYING MUTAGENS: THE RESULTS OF A VALIDATION STUDY; MUTAT. RES. 412(2):115-130, 1998 4180-23-8 p-propenylanisole; Benzene, 1-methoxy-4-(1-propenyl)- C/C=C\c1ccc(OC)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) TO,LP, HUNT,TP AND MELVIN,EA; MUTAGENICITY OF TRANS-ANETHOLE, ESTRAGOLE, EUGENOL, AND SAFROLE IN THE AMES SALMONELLA TYPHIMURIUM ASSAY; BULL. ENVIRON. CONTAM. TOXICOL. 28:647-654, 1982 107-13-1 Acrylonitrile;2-propenenitrile C=CC#N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Zeiger,E and Haworth,S; TESTS WITH A PREINCUBATION MODIFICATION OF THE SALMONELLA/MICROSOME ASSAY; PROG. MUTAT. RES. 5(EVAL. SHORT-TERM TESTS CARCINOG.):187-199, 1985 29611-03-8 Aflatoxicol COc1cc2c(C3C=COC3O2)c2c1C1CCC(O)C=1C(=O)O2 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Yourtee,DM and KIRK-YOURTEE,CL; THE MUTAGENICITY OF AFLATOXIN Q1 TO SALMONELLA TYPHIMURIUM TA 100 WITH OR WITHOUT RAT OR HUMAN LIVER MICROSOMAL PREPARATIONS; RES. COMMUN. CHEM. PATHOL. PHARMACOL. 54(1):101-113, 1986 1162-65-8 Aflatoxin B1 COc1cc2c(C3C=COC3O2)c2c1C1CCC(=O)C=1C(=O)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kfir,R, Johannsen,E and VLEGGAAR,R; MUTAGENIC ACTIVITY OF AUSTOCYSTINS - SECONDARY METABOLITES OF ASPERGILLUS USTUS;BULL. ENVIRON. CONTAM. TOXICOL. 37(5):643-650, 1986 106-92-3 allyl glycidyl ether;oxirane, 2-[(2-propen-1-yloxy)methyl]- C=CCOCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NCI/NTP Carcinogenesis Technical Report Series; NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM; U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, TR-376 Y90 77094-11-2 2-Amino-3,4-dimethylimidazo(4,5-f)quinoline Cc1cc2c(cccn2)c2c1N(C)C(N)=N2 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) LIU,X, CHENG,S, AND LI,M; PRELIMINARY STUDY ON MUTAGENICITY OF MEIQ AND EXTRACTS OF FRIED FISH AND ANTIMUTAGENICITY OF SOME DIETARY FACTORS; ZHONGGUO YIXUE KEXUEYUAN XUEBAO 11(2):97-101, 1989 67730-10-3 2-aminodipyrido[1,2-a:3',2'-d]imidazole Nc1ccc2c(n1)N1C=CC=CC1=N2 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) N'Goy, K., Saint-Ruf, G., de Meester, C., Mutagenicity of Some Derivatives of Dipyrido[1,2-a:3',2'-d]Imidazoles in Salmonella typhimurium with Metabolic Activation by Rat Liver and Small Intestine Subcellular Fractions. Mutat. Res., 1985, 156(1-2), 53 - 59 56-55-3 Benz(a)anthracene c1cccc2ccc3cc4ccccc4cc3c12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Brown, Jp. and Brown, Rj.; Mutagenesis by 9,10-Anthraquinone Derivatives and Related Compounds in Salmonella Typhimurium; Mutat. Res. 40:203-224, 1976 58917-67-2 Benzo(a)pyrene diolepoxide I OC1C(O)C2C(c3c1cc1ccc4cccc5ccc3c1c45)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GREEN,JL, PAN,YHL AND REED,GA; MUTAGENICITY OF BENZO[A]PYRENE BAY-REGION SULFONATES; CARCINOGENESIS 12(7):1359-1362, 1991 14618-80-5 Oxirane, ((phenylmethoxy)methyl)-, (R)- (9CI) C(C1CO1)OCc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SINSHEIMER,JE, CHEN,R, DAS,SK, HOOBERMAN,BH, OSORIO,S AND YOU,Z; THE GENOTOXICITY OF ENANTIOMERIC ALIPHATIC EPOXIDES; MUTAT. RES. 298(3):197-206, 1993 106-94-5 1-bromopropane CCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) E.D. Barber, W.H. Donish, K.R. Mueller, A procedure for the quantitative measurement of the mutagenicity of volatile liquids in the Ames salmonella/microsome assay, Mutat Res 90 (1) (1981) 31-48. 106-99-0 1,3-butadiene C=CC=C in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Arce, GT., et. al.; In Vitro and in Vivo Genotoxicity of 1,3-Butadiene and Metabolites; Environ. Health Perspect. 86:75-78, 1990 930-22-3 3,4-epoxy-1-butene;oxirane, ethenyl- C=CC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Canter, Da., et. al.; Comparative Mutagenicity of Aliphatic Epoxides in Salmonella; Mutat. Res. 172(2):105-138, 1986 2426-08-6 1-butoxy-2,3-epoxypropane; oxirane, 2-(butoxymethyl)- CCCCOCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Canter, Da., et. al.; Comparative Mutagenicity of Aliphatic Epoxides in Salmonella; Mutat. Res. 172(2):105-138, 1986 12789-03-6 chlordane ClC1CC2C(C1Cl)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T AND MORTELMANS,K; SALMONELLA MUTAGENICITY TESTS. V. RESULTS FROM THE TESTING OF 311 CHEMICALS; ENVIRON. MOL. MUTAGEN. 19(SUPPL.21):2-141, 1992 1086-00-6 1-Chloromethylpyrene ClCc1ccc2ccc3cccc4ccc1c2c34 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ashby, J., Gallagher, Je., Kohan, M., Tinwell, H., Kimber, I., Paton, D., Callander, Rd. and Chouroulinkov, I.; 1-Chloromethylpyrene: A Reference Skin Sensitizer And Genotoxin; Mutat. Res. 243(4):281-9, 1990 218-01-9 chrysene;chrysene benzophenanthrene c1cccc2ccc3c4ccccc4ccc3c12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GLATT,H, SEIDEL,A, BOCHNITSCHEK,W, MARQUARDT,H, MARQUARDT,H, HODGSON,RM, GROVER,PL AND OESCH,F; MUTAGENIC AND CELL-TRANSFORMING ACTIVITIES OF TRIOL-EPOXIDES AS COMPARED TO OTHER CHRYSENE METABOLITES; CANCER RES. 46(9): 4556-4565, 1986 2303-16-4 Diallate; Carbamic acid, diisopropylthio-, S-(2,3-dichloroallyl) ester CC(C)N(C(C)C)C(=O)SCC(Cl)=CCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SANDHU,SS, WATERS,MD, MORTELMANS,KE, EVANS,EL, JOTZ,MM, MITCHELL,AD AND KASICA, V; EVALUATION OF DIALLATE AND TRIALLATE HERBICIDES FOR GENOTOXIC EFFECTS IN A BATTERY OF IN VITRO AND SHORT-TERM IN VIVO TESTS; MUTAT. RES. 136(6):173-183, 1984 720-69-4 4,6-diamino-2-(5-nitro-2-furyl)-1,3,5-triazine Nc1nc(N)nc(n1)-c1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215 194-59-2 7H-Dibenzo(c,g)carbazole c1cccc2ccc3c(c12)-c1c2ccccc2ccc1N3 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) XUE,W, LADOW,K AND WARSHAWSKY,D; SYNTHESIS, CHARACTERIZATION, AND MUTAGENICITY OF NITRATED 7H-DIBENZO[C,G]CARBAZOLE AND ITS PHENOLIC DERIVATIVES; CHEM. RES. TOXICOL. 10(4):432-438, 1997 10318-26-0 dibromodulcitol; mitolactol OC(CBr)C(O)C(O)C(O)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MORTELMANS,K, HAWORTH,S, LAWLOR,T, SPECK,W, TAINER,B AND ZEIGER,E; SALMONELLA MUTAGENICITY TESTS: II. RESULTS FROM THE TESTING OF 270 CHEMICALS; ENVIRON. MUTAGEN. 8(SUPPL. 7):1-119, 1986 101-90-6 diglycidyl resorcinol ether C(C1CO1)Oc1cccc(OCC2CO2)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NCI/NTP CARCINOGENESIS TECHNICAL REPORT SERIES; NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM; U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, TR-257 Y86 55738-54-0 trans-2-[(dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazo CN(C)CN=C1NN=C(O1)C=Cc1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NCI; THE SALMONELLA TYPHIMURIUM/MAMMALIAN MICROSOMAL ASSAY: A REPORT OF THE U.S. ENVIRONMENTAL PROTECTION AGENCY GENE-TOX PROGRAM; MUTAT RES 168:69-240,1986 26049-69-4 2-(2,2-dimethylhydrazino)-4-(5-nitro-2-furyl)thiazole CN(C)Nc1nc(cs1)-c1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215 106-89-8 epichlorohydrin; oxirane, 2-(chloromethyl)- ClCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Brams, A., et. al.; A Comparative Study, With 40 Chemicals, Of The Efficiency Of The Salmonella Assay And The SOS Chromotest (Kit Procedure); Toxicol. Lett. 38(1-2):123-133, 1987 26761-45-5 neodecanoic acid, 2,3-epoxypropyl ester CCC(C)(CCC(C)C)C(=O)OCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) http://apps.echa.europa.eu/registered/data/dossiers/DISS-828e0875-b718-1c7e-e044-00144fd73934/AGGR-4a38cebe-cc09-4b3b-8f8e-b06e7e95b7ca_DISS-828e0875-b718-1c7e-e044-00144fd73934.html#AGGR-4a38cebe-cc09-4b3b-8f8e-b06e7e95b7ca 151-56-4 ethyleneimine; aziridine C1CN1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MCCANN,J, CHOI,E, YAMASAKI,E AND AMES,BN; DETECTION OF CARCINOGENS AS MUTAGENS IN THE SALMONELLA/MICROSOME TEST: ASSAY OF 300 CHEMICALS; PROC. NATL. ACAD. SCI. USA 72(12):5135-5139, 1975 3570-75-0 nifurthiazole;formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide [O-][N+](=O)c1ccc(o1)-c1csc(NNC=O)n1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 5694-00-8 glycidamide;oxirane-2-carboxamide NC(=O)C1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HASHIMOTO,K AND TANII,H; MUTAGENICITY OF ACRYLAMIDE AND ITS ANALOGUES IN SALMONELLA TYPHIMURIUM; MUTAT. RES. 158(3):129-133, 1985 2461-42-9 glycidyl 1-naphthyl ether C(C1CO1)Oc1cccc2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) EINISTO,P, HOOBERMAN,BH AND SINSHEIMER,JE; BASE-PAIR MUTATIONS CAUSED BY SIX ALIPHATIC EPOXIDES IN SALMONELLA TYPHIMURIUM TA100, TA104, TA4001, AND TA4006; ENVIRON. MOL. MUTAGEN. 21(3):253-257, 1993 106268-95-5 (r)-glycidyl 4-nitrobenzoate [O-][N+](=O)c1ccc(cc1)C(=O)OCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SINSHEIMER,JE, CHEN,R, DAS,SK, HOOBERMAN,BH, OSORIO,S AND YOU,Z; THE GENOTOXICITY OF ENANTIOMERIC ALIPHATIC EPOXIDES; MUTAT. RES. 298(3):197-206, 1993 5255-75-4 glycidyl 4-nitrophenyl ether [O-][N+](=O)c1ccc(OCC2CO2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) EINISTO,P, HOOBERMAN,BH AND SINSHEIMER,JE; BASE-PAIR MUTATIONS CAUSED BY SIX ALIPHATIC EPOXIDES IN SALMONELLA TYPHIMURIUM TA100, TA104, TA4001, AND TA4006; ENVIRON. MOL. MUTAGEN. 21(3):253-257, 1993 556-52-5 glycidol; 2-oxiranemethanol OCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005 33389-36-5 Quinazoline, 4-(2-hydroxyethylamino)-2-(5-nitro-2-thienyl)- OCCNc1nc(nc2ccccc12)-c1ccc(s1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MCCANN,J, CHOI,E, YAMASAKI,E AND AMES,BN; DETECTION OF CARCINOGENS AS MUTAGENS IN THE SALMONELLA/MICROSOME TEST: ASSAY OF 300 CHEMICALS; PROC. NATL. ACAD. SCI. USA 72(12):5135-5139, 1975 5036-03-3 1-(2-hydroxyethyl)-3-[(5-nitrofurfurylidene)amino]-2-imidazolidinone;nifurdazil OCCN1CCN(N=Cc2ccc(o2)[N+]([O-])=O)C1=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 21638-36-8 Nifurimide CC1CN(N=Cc2ccc(o2)[N+]([O-])=O)C(=O)N1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 50-07-7 mitomycin-c CC1=C(N)C(=O)C2C(COC(N)=O)C3(OC)C4C(CN3C=2C1=O)N4 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SAKAMOTO,Y, FUJIKAWA,K, NAGAYABU,O, YAMAMOTO,KS AND SAMEJIMA,K; TRIPLE SHORT-TERM TESTS WITH BACTERIA AND DROSOPHILA FOR ASSESSMENT OF MUTAGENICITY OF ANTINEOPLASTICS; TAKEDA KENKYUSHOHO 44(1/2):96-116, 1985 58139-48-3 4-morpholino-2-(5-nitro-2-thienyl)quinazoline [O-][N+](=O)c1ccc(s1)-c1nc2ccccc2c(n1)N1CCOCC1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 68884-32-2 1-naphthylpropylene oxide C1C(Cc2cccc3ccccc23)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ROSMAN,LB, GADDAMIDI,V AND SINSHEIMER,JE; MUTAGENICITY OF ARYL PROPYLENE AND BUTYLENE OXIDES WITH SALMONELLA; MUTAT. RES. 189(3):189-204, 1987 23256-30-6 Nifurtimox CC1CS(=O)(=O)CCN1N=Cc1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) FERREIRA,RCC AND FERREIRA,LCS; MUTAGENICITY OF NIFURTIMOX AND BENZNIDAZOLE IN THE SALMONELLA/MICROSOME ASSAY; BRAZ. J. MED. BIOL. RES. 19(1):19-25, 1986 2578-75-8 n-(5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl)acetamide CC(=O)Nc1nnc(s1)-c1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 531-82-8 n-(4-(5-nitro-2-furyl)-2-thiazolyl)acetamide CC(=O)Nc1nc(cs1)-c1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) RINKUS,SJ AND LEGATOR,MS; CHEMICAL CHARACTERIZATION OF 465 KNOWN OR SUSPECTED CARCINOGENS AND THEIR CORRELATION WITH MUTAGENIC ACTIVITY IN THE SALMONELLA TYPHIMURIUM SYSTEM; CANCER RES. 39:3289-3318, 1979][SUGIMURA,T, SATO,S, NAGAO,M, YAHAGI,T, MATSUSHIMA,T, SEINO,Y, TAKEUCHI,M AND KAWAC HI,T; OVERLAPPING OF CARCINOGENS AND MUTAGENS; IN: MAGEE,PN, TAKAYAMA,S, SUGIMURA,T AND MATSUSHIMA,T (EDS.), FUNDAMENTALS IN CANCER PREVENTION, UNIVERSITY PARK PRESS, BALTIMORE, MARYLAND, 1976, PP. 191-215 51325-35-0 n,n'-[6-(5-nitro-2-furyl)-s-triazine-2,4-diyl]bisacetamide CC(=O)Nc1nc(NC(C)=O)nc(n1)-c1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 5522-43-0 1-nitropyrene;pyrene, 1-nitro- [O-][N+](=O)c1ccc2ccc3cccc4ccc1c2c34 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) EL-BAYOUMY,K AND HECHT,SS; MUTAGENICITY OF K-REGION DERIVATIVES OF 1-NITROPYRENE; REMARKABLE ACTIVITY OF 1- AND 3-NITRO-5H-PHENANTHRO[4,5-BCD]PYRAN-5-ONE; MUTAT. RES. 170(1-2):31-40, 1986 607-35-2 8-nitroquinoline;quinoline, 8-nitro- [O-][N+](=O)c1cccc2cccnc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 122-60-1 phenylglycidyl ether oxirane C(C1CO1)Oc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Canter, Da., et. al.; Comparative Mutagenicity of Aliphatic Epoxides in Salmonella; Mutat. Res. 172(2):105-138, 1986 75-56-9 1,2-propylene oxide CC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ROSMAN,LB, GADDAMIDI,V AND SINSHEIMER,JE; MUTAGENICITY OF ARYL PROPYLENE AND BUTYLENE OXIDES WITH SALMONELLA; MUTAT. RES. 189(3):189-204, 1987 299-75-2 Treosulfan CS(=O)(=O)OCC(O)C(O)COS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Zeiger, E., Pagano, D.A., Mutagenicity of the Human Carcinogen Treosulphan in Salmonella. Environ. Mol. Mutagen., 1989, 13(4), 343 - 346 3083-23-6 1,2-epoxy-3,3,3-trichloropropane ClC(Cl)(Cl)C1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) EINISTO,P, HOOBERMAN,BH AND SINSHEIMER,JE; BASE-PAIR MUTATIONS CAUSED BY SIX ALIPHATIC EPOXIDES IN SALMONELLA TYPHIMURIUM TA100, TA104, TA4001, AND TA4006; ENVIRON. MOL. MUTAGEN. 21(3):253-257, 1993 51-18-3 2,4,6-tris(1-aziridinyl)-s-triazine;tretamine C1CN1c1nc(N2CC2)nc(N2CC2)n1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SAKAMOTO,Y, FUJIKAWA,K, NAGAYABU,O, YAMAMOTO,KS AND SAMEJIMA,K; TRIPLE SHORT-TERM TESTS WITH BACTERIA AND DROSOPHILA FOR ASSESSMENT OF MUTAGENICITY OF ANTINEOPLASTICS; TAKEDA KENKYUSHOHO 44(1/2):96-116, 1985 2451-62-9 Triglycidyl isocyanurate O=C1N(CC2CO2)C(=O)N(CC2CO2)C(=O)N1CC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T AND MORTELMANS,K; SALMONELLA MUTAGENICITY TESTS. V. RESULTS FROM THE TESTING OF 311 CHEMICALS; ENVIRON. MOL. MUTAGEN. 19(SUPPL.21):2-141, 1992 15805-73-9 Vinyl carbamate C=COC(N)=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Dahl, G.A., Miller, E.C., Miller, J.A., Comparative Carcinogenicities and Mutagenicities of Vinyl Carbamate, Ethyl Carbamate, and Ethyl N-Hydroxycarbamate. Cancer Res., 1980, 40(4), 1194 - 1203 67730-11-4 2-Amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole CC1=CC=CN2C1=Nc1ccc(N)nc21 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Peters, J.H., Mortelmans, K.E., Reist, E.J., Sigman, C.C., Spanggord, R.J., Thomas, D.W., Synthesis, Chemical Characterization, and Mutagenic Activities of Promutagens Produced by Pyrolysis of Proteinaceous Substances. Environ. Mutagen., 1981, 3(6), 639 û 649 76180-96-6 2-amino-3-methyl-3h-imidazo[4,5-f]quinoline CN1c2ccc3c(cccn3)c2N=C1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Carman, RJ., et. al.; Conversion Of IQ, A Dietary Pyrolysis Carcinogen To A Direct-Acting Mutagen By Normal Intestinal Bacteria Of Humans; Mutat. Res. 206(3):335-342, 1988 16387-26-1 2-Methyl-3,3,3-trichloropropylene oxide CC1(C(Cl)(Cl)Cl)CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Wade, D.R., Airy, S.C., Sinsheimer, J.E., Mutagenicity of aliphatic epoxides. Mutat. Res., 1978, 58(2-3), 217-223. 7763-77-1 chloroethylene oxide ClC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 2429-74-5 C.I. Direct Blue 15 COc1cc(-c2ccc(NN=C3C(S(=O)(=O)O{-}.[Na]{+})=Cc4cc(S(=O)(=O)O{-}.[Na]{+})cc(N)c4C3=O)c(OC)c2)ccc1NN=C1C(S(=O)(=O)O{-}.[Na]{+})=Cc2cc(S(=O)(=O)O{-}.[Na]{+})cc(N)c2C1=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NCI/NTP CARCINOGENESIS TECHNICAL REPORT SERIES; NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM; U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, TR-397 Y92 56-53-1 Diethylstilbestrol CCC(=C(CC)c1ccc(O)cc1)c1ccc(O)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 60-57-1 Dieldrin ClC1=C(Cl)C2(Cl)C3C4CC(C3C1(Cl)C2(Cl)Cl)C1C4O1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 76-44-8 Heptachlor ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 77-73-6 Dicyclopentadiene C1C=CC2C1C1CC2C=C1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 78-79-5 Isoprene CC(=C)C=C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 91-20-3 Naphtalene c1cccc2ccccc12 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 92-52-4 Biphenyl c1ccccc1-c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 93-15-2 Methyleugenol COc1ccc(CC=C)cc1OC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 94-59-7 Safrole C=CCc1ccc2c(c1)OCO2 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-50-1 1,2-dichlorobenzene Clc1ccccc1Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 98-00-0 Furfuryl alcohol OCC1=CC=CO1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 98-83-9 alpha-Methylstyrene CC(=C)c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 100-40-3 4-Vinyl-1-cyclohexene C=CC1CCC=CC1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 110-02-1 Thiophene C1=CC=CS1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 126-98-7 Methylacrylonitrile CC(=C)C#N in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 140-67-0 Estragole; 1-Methoxy-4-(2-propenyl)benzene COc1ccc(CC=C)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 534-22-5 Methyl furan CC1=CC=CO1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 541-73-1 1,3-Dichlorobenzene Clc1cccc(Cl)c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 623-15-4 Furfural Acetone CC(=O)C=CC1=CC=CO1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 924-42-5 N-Methylolacrylamide C=CC(=O)NCO in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 2682-20-4 4-Isothiazolin-3-One,2-Methyl- CN1C(=O)C=CS1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 6197-30-4 2-Ethylhexyl-2-Cyano-3,3'diphenyl Acrylate CCCCC(CC)COC(=O)C(C#N)=C(c1ccccc1)c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 16219-75-3 Ethylidene norbornene CC=C1CC2CC1C=C2 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 674-82-8 2-oxetanone, 4-methylene- C=C1CC(=O)O1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN;1996 110-93-0 6-Methyl-5-hepten-2-one CC(C)=CCCC(C)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Florin I., et al., Toxicology, 18, 219-232, 1980. 78-70-6 Linalool CC(C)=CCCC(C)(O)C=C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Belsito, D., Bickers, D., Bruze, M., Calow, P., Greim, H., Hanifin, J.M., Rogers, A.E., Saurat, J.H., Sipes, I.G., Tagami, H., A safety assessment of non-cyclic alcohols with unsaturated branched chain when used as fragrance ingredients: the RIFM expert panel. Food Chem. Toxicol., 2010, 48(3), S1-S42. 87-44-5 beta-Caryophyllene CC1CCC{P+}2C{P+}(CC2(C)C)C(=C)CCC=1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Short-Term Testing Program in the National Cancer Institute (NCI), National Institutes of Health, US Department of Health and Human Services 80-56-8 alpha-Pinene CC1=CCC2CC1C2(C)C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 99-85-4 p-Mentha-1,4-diene CC(C)C1CC=C(C)CC=1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) EFSA Journal 2011; 9 (6): 2178 1139-30-6 beta-Caryophyllene oxide CC1(C)CC{P-}2C{P-}1CCC{P+}1(C)C{P+}(CCC2=C)O1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) The EFSA Journal (2009) 937, 1-22 2216-69-5 1-Methoxynaphthalene COc1cccc2ccccc12 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 3048-65-5 3a,4,7,7a-Tetrahydroindene C1C=CCC2CC=CC12 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 91-76-9 2,4-Diamino-6-phenyl-1,3,5-triazine Nc1nc(-c2ccccc2)nc(N)n1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 4286-23-1 p-Isopropenylphenol CC(=C)c1ccc(O)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 106-37-6 p-Dibromobenzene Brc1ccc(Br)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 2768-02-7 Vinyltrimethoxysilane CO[Si](C=C)(OC)OC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 7756-94-7 Triisobutylene CC(=C)CC(C)(C)CC(C)(C)C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 110-83-8 Cyclohexene C1CCCC=C1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 3846-71-7 2-(2'-Hydroxy-3',5'-di-tert-butylphenyl)benzotriazole CC(C)(C)c1cc(C(C)(C)C)cc(N2N=C3C=CC=CC3=N2)c1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 691-37-2 4-Methyl-1-pentene CC(C)CC=C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 76-83-5 Chlorotriphenylmethane ClC(c1ccccc1)(c1ccccc1)c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 71-43-2 Benzene c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Brams, A., et. al.; A Comparative Study, With 40 Chemicals, Of The Efficiency Of The Salmonella Assay And The SOS Chromotest (Kit Procedure); Toxicol. Lett. 38(1-2):123-133, 1987; Baker, Rsu. and Bonin, Am.; Tests With The Salmonella Plate-Incorporation Assay; Prog. Mutat. Res. 5(Eval. Short-Term Tests Carcinog.):177-180, 1985; Stark, Aa. and Rastetter, Wh.; Structure-Activity Relationships In The Mutagenicity And Cytotoxicity Of Putative Metabolites And Related Analogs Of Benzene Derived From The Valence Tautomers Benzene Oxide And Oxepin; Environ. Mol. Mutagen. 28(3):284-293, 1996 123-35-3 Myrcene CC(C)=CCCC(=C)C=C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Hansen et al. J. Chem. Inf. Model., 2009, 49 (9), pp 2077-2081 11097-69-1 Aroclor 1254 Clc1cccc(-c2ccc(Cl)c(Cl)c2Cl)c1Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 156-59-2 cis-1,2-Dichloroethylene Cl/C=C\Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 120-11-6 Isoeugenyl benzyl ether C/C=C/c1ccc(OCc2ccccc2)c(OC)c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Wild D., et al., Fd. Chem. Toxic., 21(6), 707-719, 1983 1604-28-0 6-Methyl-3,5-heptadien-2-one CC(C)=C/C=C/C(C)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Florin I., et al. Toxicology, v.18, pp.219=232 4602-84-0 Farnesol CC(C)=CCC/C(C)=C/CC/C(C)=C/CO in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Concalves O., et al., Mutation Research v. 723, pp. 1825 (2011) 10339-55-6 1,6-nonadien-3-ol, 3,7-dimethyl- CCC(C)=CCCC(C)(O)C=C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) ECHA, Registration dossier. 1,6-nonadien-3-ol, 3,7-dimethyl- CAS No 10339-55-6; https://echa.europa.eu/registration-dossier/-/registered-dossier/13181/7/7/2/?documentUUID=9f549442-4597-469c-8fbc-7f18a4003a7b 604-75-1 Oxazepam OC1C(=O)Nc2ccc(Cl)cc2C(c2ccccc2)=N1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Snyder, R. D. (2009). An update on the genotoxicity and carcinogenicity of marketed pharmaceuticals with reference to in silico predictivity. Environmental and Molecular Mutagenesis, 50(6), 435û450. 1321-74-0 Vinylstyrene C=Cc1ccccc1C=C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 309-00-2 Aldrin ClC1=C(Cl)C{P-}2(Cl)C{P+}3C{P+}4CC{P+}(C=C4)C{P+}3C{P+}1(Cl)C2(Cl)Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory