CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity without S9	#Observed Mutagenicity with S9	Bioassay - 	Reference(s) -
3068-88-0	beta-Butyrolactone	CC1CC(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25"
1955-45-9	Pivalolactone	CC1(C)COC1=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25"
57-57-8	Beta-Propiolactone	O=C1CCO1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240"
50-81-7	Vitamin C	OCC(O)C1C(O)=C(O)C(=O)O1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
*-16-6		COc1cc(C{P-}2C{P-}3C{P+}(COC3=O)C{P+}(OC{P-}3C{P-}(O)C{P-}(O)C{P-}4C{P-}(COC{P-}(C5=CC=CS5)O4)O3)c3cc4c(cc23)OCO4)cc(OC)c1O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199"
57074-49-4	Furo(2',3':5,6)cyclohepta(1,2-c)pyran-2(3H)-one,_decahydro-5,7-diethoxy-4a,9-dimethyl-3-methylene-; Diethylhymenovin"	CCOC1CC2C(C)CC3C(CC2(C)C(OCC)O1)C(=C)C(=O)O3	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25"
57074-51-8	Hymenovin	CC1CC2C(CC3(C)C1CC(O)OC3O)C(=C)C(=O)O2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240"
1748-81-8	Carabrone	CC(=O)CCC1C2CC3C(CC12C)OC(=O)C3=C	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"STUPPNER,H. et al ,PHYTOCHEMISTRY 27(8):2681-2684, 1988"
57377-32-9	Hymenoxone	CC{P+}1CC{P+}2C{P+}(CC{P-}3(C)C{P-}1CC{P+}(O)OC{P-}3O)C(=C)C(=O)O2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Jones DH,  Toxicol Lett., 9, pp. 395-401. (1981)"
508-59-8	Parthenin	CC{P-}1CCC{P+}2C{P+}(C{P+}3(C)C(=O)C=CC{P+}13O)OC(=O)C2=C	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Ramos A. , Mutation Research, v.514, pp.19-27, (2002)"
33419-42-0	Etoposide	CC1OCC2C(C(O)C(O)C(OC3C4COC(=O)C4C(c4cc(OC)c(O)c(OC)c4)c4cc5c(cc34)OCO5)O2)O1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Nakanomyo, H., Hiraoka, M., Shiraya, M., Mutagenicity Tests of Etoposide and Teniposide. J. Toxicol. Sci., 1986, 11(Suppl.1), 301 - 310)"
674-82-8	2-oxetanone,_4-methylene-	C=C1CC(=O)O1	in vitro Ames negative	in vitro Ames negative	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN;1996"
96-48-0	gamma-Butyrolactone	O=C1CCCO1	in vitro Ames negative	in vitro Ames negative	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25"
104-67-6	2(3H)-Furanone, 5-heptyldihydro-	CCCCCCCC1CCC(=O)O1	in vitro Ames negative	in vitro Ames negative	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"FUJITA,H., KENKYU NENPO - TOKYO-TORITSU EISEI KENKYUSHO 38:423-430, 1987"
105-21-5	gamma-Heptalactone	CCCC1CCC(=O)O1	in vitro Ames negative	in vitro Ames negative	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Heck J., et al., Toxicologist, 9, 257, 1989"
518-28-5	Podofilox; podophyllotoxin;	COc1cc(C2C3C(COC3=O)C(O)c3cc4c(cc23)OCO4)cc(OC)c1OC	in vitro Ames negative	in vitro Ames negative	Bacterial Reverse Mutation Assay (e.g. Ames Test)	"Lin, M.C., Cheng, H.W., Tsai, Y.C., Liao, P.L., Kang, J.J., Cheng, Y.W.,  Podophyllin, but not the constituents quercetin or kaempferol, induced genotoxicity in vitro and in vivo through ROS production. Drug Chem. Toxicol., 2009, 32(1), 68-76."