CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 78-87-5 1,2-Dichloro-Propane CC(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 302-17-0 Chloral Hydrate OC(O)C(Cl)(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 106-93-4 1,2-Dibromoethane BrCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 127-00-4 1-Chloro-2-Propanol CC(O)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 19686-73-8 1-Bromo-2-Propanol CC(O)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 52-68-6 Trichlorfon COP(=O)(C(O)C(Cl)(Cl)Cl)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 540-51-2 2-Bromo-1-Ethanol OCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 554-10-9 3-Iodo-1,2-Propanediol OCC(O)CI in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 616-23-9 2,3-Dichloro-1-Propanol OCC(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 627-18-9 3-Bromo-1-Propanol OCCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 74-96-4 Ethyl Bromide CCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 96-13-9 2,3-Dibromo-1-Propanol OCC(Br)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 96-23-1 1,3-Dichloro-2-Propanol OC(CCl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 75-26-3 2-Bromopropane CC(C)Br in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 75-00-3 Ethyl Chloride CCCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 154-93-8 Carmustine O=C(NCCCl)N(CCCl)N=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 *6-00-9 ICR 442 CC(Cl)CNCCNc1c2ccccc2nc2ccc(OC)cc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199 *6-01-3 ICR 443 CC(Cl)CNCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) DeMarini D.M.,et.al, Relationships between structures and mutagenic potencies of 16 heterocyclic nitrogen mustards (ICR compounds) in Salmonella typhimurium Mut.Research, 136 (1984) 185-199 112-26-5 1,2-Bis(2-chloroethoxy)ethane ClCCOCCOCCCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 109-70-6 1-bromo-3-chloropropane;_Propane,_1-bromo-3-chloro- ClCCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 75-87-6 Trichloroacetaldehyde O=CC(Cl)(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) WASKELL,L; A STUDY OF THE MUTAGENICITY OF ANESTHETICS AND THEIR METABOLITES; MUTAT. RES. 57:141-153, 1978 31555-54-1 3,4-dichloro-5-dichloromethylene-2-furanone O=C1C(Cl)=C(Cl)C(=C(Cl)Cl)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 112654-68-9 3-chloro-5-dichloromethylene-2-furanone O=C1C(Cl)=CC(=C(Cl)Cl)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SMEDS,A, FRANZEN,R AND KRONBERG,L; ENVIRON. SCI. TECHNOL. 29(9):18391844, 1995 79-00-5 1,1,2-Trichloroethane ClCC(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) STROBEL,K AND GRUMMT,T; ALIPHATIC AND AROMATIC HALOCARBONS AS POTENTIAL MUTAGENS IN DRINKING WATER. III. HALOGENATED ETHANES AND ETHENES; TOXICOL. ENVIRON. CHEM. 15(1-2):101-128, 1987; 107-07-3 2-Chloroethanol OCCCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Toxicology and Carcinogenesis Studies of 2-Chloroethanol (Ethylene Chlorohydrin) (CAS No. 107-07-3) in F344/N Rats and Swiss CD-1 Mice (Dermal Studies), US Dept. of Health and Human Services, Public health Service, NIH, November 1985 488-41-5 Mitobronitol OC{P+}(CBr)C{P-}(O)C{P+}(O)C{P+}(O)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 107-06-2 1,2-Dichloro-ethane ClCCCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 4823-47-6 Acrylic acid, 2-bromoethyl ester C=CC(=O)OCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 109-64-8 1,3-Dibromopropane BrCCCBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 111-44-4 1-Chloro-2-(2-chloro-ethoxy)-ethane; Bis(2-Chloroethyl)Ether ClCCOCCCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 126-72-7 Tris(2,3-Dibromopropyl)Phosphate O=P(OCC(Br)CBr)(OCC(Br)CBr)OCC(Br)CBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 140-49-8 4'-(Chloroacetyl) Acetanilide CC(=O)Nc1ccc(C(=O)CCl)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 627-30-5 3-Chloro-1-Propanol OCCCCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 2206-89-5 2-Chloroethyl Acrylate C=CC(=O)OCCCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 3066-70-4 2-Propenoic_acid,_2-methyl-,_2,3-dibromopropyl_ester CC(=C)C(=O)OCC(Br)CBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 13674-87-8 Tris(1,3-Dichloro-2-Propyl)Phosphate O=P(OC(CCl)CCl)(OC(CCl)CCl)OC(CCl)CCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 19660-16-3 2,3-Dibromopropyl crylate C=CC(=O)OCC(Br)CBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 106-94-5 1-bromopropane CCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) E.D. Barber, W.H. Donish, K.R. Mueller, A procedure for the quantitative measurement of the mutagenicity of volatile liquids in the Ames salmonella/microsome assay, Mutat Res 90 (1) (1981) 31-48. 12789-03-6 chlordane ClC1CC2C(C1Cl)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T AND MORTELMANS,K; SALMONELLA MUTAGENICITY TESTS. V. RESULTS FROM THE TESTING OF 311 CHEMICALS; ENVIRON. MOL. MUTAGEN. 19(SUPPL.21):2-141, 1992 90301-59-0 5-(2-chloroethyl)-2'-deoxyuridine;5-(2-cloroethyl)-2'-deoxyuridine OCC1C(O)CC(N2C=C(CCCl)C(=O)NC2=O)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Suter, W., Plappert-Helbig, U., Glowienke, S., Poetter-Locher, F., Staedtler, F., Racine, R., Martus, H.J., Induction of Gene Mutations by 5-(2-Chloroethyl)-2'-Deoxyuridine (CEDU), an Antiviral Pyrimidine Nucleoside Analogue. Mutat. Res., 2004, 568(2), 195 - 209 13909-09-6 Semustine; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea CC1CCC(NC(=O)N(CCCl)N=O)CC1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ashby, J, et. el.; Mutagenicity to Salmonella, Drosophila and the Mouse Bone Marrow of the Human Antineoplastic Agent Fotemustine: Prediction Of Carcinogenic Potency; Mutat. Res. 286(1):101- 109, 1993 10318-26-0 Dibromodulcitol; mitolactol OC(CBr)C(O)C(O)C(O)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MORTELMANS,K, HAWORTH,S, LAWLOR,T, SPECK,W, TAINER,B AND ZEIGER,E; SALMONELLA MUTAGENICITY TESTS: II. RESULTS FROM THE TESTING OF 270 CHEMICALS; ENVIRON. MUTAGEN. 8(SUPPL. 7):1-119, 1986 106-89-8 Epichlorohydrin; oxirane, 2-(chloromethyl)- ClCC1CO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Brams, A., et. al.; A Comparative Study, With 40 Chemicals, Of The Efficiency Of The Salmonella Assay And The SOS Chromotest (Kit Procedure); Toxicol. Lett. 38(1-2):123-133, 1987 92118-27-9 Fotemustine CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ashby, J, et. el.; Mutagenicity to Salmonella, Drosophila and the Mouse Bone Marrow of the Human Antineoplastic Agent Fotemustine: Prediction Of Carcinogenic Potency; Mutat. Res. 286(1):101- 109, 1993 5634-39-9 Iodinated glycerol;2-(1-iodoethyl)-1,3-dioxolan-4-ylmethanol; CC(I)C1OCC(CO)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NCI/NTP carcinogens technical report series; NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM; U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, TR-340 Y90][ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T, MORTELMANS,K AND SPECK,W; SALMONELLA MUTAGENICITY TESTS: III. RESULTS FROM THE TESTING OF 255 CHEMICALS; ENVIRON. MOL. MUTAGEN. 9(SUPPL.9):1-110, 1987 71-55-6 Methylchloroform CC(Cl)(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Strubel, K., T. Grummt, Aliphatic and Aromatic Halocarbons as Potential Mutagens in Drinking Water. III. Halogenated Ethanes and Ethenes, Toxicol. Environ. Chem. 15(1-2) (1987), 101 – 128 76-44-8 Heptachlor ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 109-69-3 N-Butyl chloride CCCCCl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory