CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 484-23-1 Dihydralazine NNc1c2ccccc2c(NN)nn1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 114-83-0 1-Acetyl-2-Phenylhydrazine CC(=O)NNc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 123-77-3 Azodicarbonamide NC(=O)N=NC(N)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 3682-19-7 4-Nitrophthalhydrazide Oc1nnc(O)c2cc(ccc12)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1576-35-8 p-Toluenesulfonyl_Hydrazide Cc1ccc(S(=O)(=O)NN)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 57-14-7 1,1-Dimethylhydrazine CN(C)N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 100-63-0 Phenylhydrazine NNc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 54-85-3 4-Pyridinecarboxylic_acid,_hydrazide;_Isoniazid;_Isonicotinic_acid_hydrazide NNC(=O)c1ccncc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Braun, R., Jaekel, Hp., and Schoeneich, J.; Genetic Effects of Isoniazid and the Relationship to in Vivo And In Vitro Biotransformation; Mutat. Res. 137(2-3): 61-69, 1984 100-16-3 4-Nitrophenylhydrazine NNc1ccc(cc1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 109-84-2 2-hydrazinoethanol NNCCO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 119-26-6 Hydrazine,_(2,4-dinitrophenyl)- NNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 304-20-1 Hydralazine_hydrochloride NNc1c2ccccc2cnn1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 820-75-7 N-Diazoacetylglycine hydrazide NNC(=O)CNC(=O)C=[N+]=[N-] in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 1068-57-1 Acetic acid hydrazide CC(=O)NN in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Bhide, S. V., Bhalerao, E. B., Sarode, A. V. and Maru, G. B.; Mutagenicity and Carcinogenicity of Mono and Diacetyl Hydrazine; Cancer Lett. 23(2):235-240, 1984 16596-38-6 1,1-bis(2-methylpropyl-hydrazine CC(C)CN(N)CC(C)C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 20970-16-5 Pyrido(2,3-d)pyridazin-5(6H)-one hydrazone NNc1c2cccnc2cnn1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 23590-73-0 Pyrido(2,3-d)pyridazin-8(7H)-one hydrazone NNc1c2c(cccn2)cnn1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MORITA,T, NAITOU,H AND OISHI,E; BIOL. PHARM. BULL. 18(2):363-367, 1995 27758-60-7 N,N-Di(p-tolyl)hydrazine Cc1ccc(N(N)c2ccc(C)cc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Aagaard Nielsen, P. et. al.; Mutagenic Activity Of Nine N,N-Disubstituted Hydrazines In The Salmonella/ Mammalian Microsome Assay; Mutat. Res. 278(4):215-226, 1992 28860-95-9 Carbidopa CC{P+}(Cc1ccc(O)c(O)c1)(C(O)=O)NN in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) KITAMURA,J. RES. COMMUN. CHEM. PATHOL. PHARMACOL. 49(3):415-422, 1985 64000-73-3 Pildralazine CC(O)CN(C)c1ccc(NN)nn1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GLATT,H AND OESCH,F; TERATOG. CARCINOG. MUTAGEN. 5(5):339-345, 1985 162022-88-0 Pyrido(3,4-d)pyridazin-1(2H)-one hydrazone NNc1c2ccncc2cnn1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MORITA,T, NAITOU,H AND OISHI,E; MUTAGENICITY OF CONDENSED PYRIDAZINES WITH DIFFERENT SUBSTITUENTS; BIOL. PHARM. BULL. 18(2):363-367, 1995 162022-89-1 Pyrido(3,4-d)pyridazin-4(3H)-one hydrazone NNc1c2cnccc2cnn1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MORITA,T, NAITOU,H AND OISHI,E; BIOL. PHARM. BULL. 18(2):363-367, 1995 7327-87-9 Dihydralazine_sulfate NNc1c2ccccc2c(NN)nn1_OS(O)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 135086-97-4 3-Amino-5H-1,2,3-triazin(5,4b)indol-4-one NN1C(=O)C2=C(c3ccccc3N2)N=N1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) LOPEZ-DE-CERAIN,A. et al ; MUTAGENESIS 7(1):37-39, 1992 302-01-2 Hydrazine NN in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996 80-51-3 4,4'-oxybis(benzenesulfonylhydrazide) NNS(=O)(=O)c1ccc(Oc2ccc(S(=O)(=O)NN)cc2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 644-21-3 1-ethyl-1-phenyl-hydrazine CCN(N)c1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Aagaard Nielsen, P. et. al.; Mutagenic Activity Of Nine N,N-Disubstituted Hydrazines In The Salmonella/ Mammalian Microsome Assay; Mutat. Res. 278(4):215-226, 1992 60-34-4 Methylhydrazine CNN in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996 110963-29-6 3-Aminoindol-2-carbohydrazide NC1=C(C(=O)NN)Nc2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) LOPEZ-DE-CERAIN,A. et al; INFLUENCE OF THE TRIAZINE RING ON THE MUTAGENICITY OF TRIAZINOINDOLES AND SOME CONGENERS; MUTAGENESIS 7(1):37-39, 1992 7803-57-8 Hydrazine hydrate NN_O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 14448-67-0 MBTH_hydrochloride Cl_CN1c2ccccc2SC1=NN in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 56413-75-3 o-Nitrophenylhydrazine hydrochloride Cl.NNc1ccccc1[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 86-54-4 Hydralazine N/N=C1C{P+}2C=CC=CC2=CN=N/1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 59-87-0 Nitrofurazone NC(=O)NN=Cc1ccc(o1)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 10034-93-2 Hydrazine, sulfate NN_OS(O)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ROGAN,EG. et al MUTAT. RES. 102:413-424, 1982 86-50-0 Gusathion COP(=S)(OC)SCN1C(=O)c2ccccc2N=N1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 921-14-2 1,1-bis(1-methylethyl)-hydrazine CC(C)N(N)C(C)C in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Aagaard Nielsen, P. et. al.; Mutagenic Activity Of Nine N,N-Disubstituted Hydrazines In The Salmonella/ Mammalian Microsome Assay; Mutat. Res. 278(4):215-226, 1992 36719-40-1 1-Triazene, 3,3-bis(1-methylethyl)-1-phenyl- CC(C)N(C(C)C)/N=N\c1ccccc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Sieh DH, Andrews AW, Michejda CJ. Mutation Research v. 73, pp. 227-235. (1980) 2757-90-6 Agaritine;beta-n-[gamma-l(+)-glutamyl]-4-hydroxymethylphenylhydrazine NC(CCC(=O)NNc1ccc(CO)cc1)C(O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Friedrich, U., B. Fischer, J. Luthy, D. Hann, Chr. Schlatter, Fr. E. Wurgler, The Mutagenic Activity of Agaritine – A Constituent of the Cultivated Mushroom Agaricus Bisporus – and Its Derivatives Detected with the Salmonella/Mammalian Microsome Assay (Ames test), Z. Lebensm. Unters Forsch 183 (1986), 85 – 89 3570-75-0 nifurthiazole;formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide [O-][N+](=O)c1ccc(o1)-c1csc(NNC=O)n1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240 6804-07-5 Carbadox COC(=O)NN=Cc1c[n+]([O-])c2ccccc2[n+]1[O-] in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Beutin, L., Preller, E., Kowalski, B., Mutagenicity of Quindoxin, Its Metabolites, and Two Substituted Quinoxaline-di-N-Oxides. Antimicrob. Agents Chemother., 1981, 20(3), 336 - 343 306-37-6 1,2-dimethylhydrazine dihydrochloride Cl_Cl_CNNC in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) S.A. Musatov, V.N. Anisimov, V. Andr้, C. Vigreux, T. Godard, P. Gauduchon, F. Sichel, Modulatory effects of melatonin on genotoxic response of reference mutagens in the Ames test and comet assay, Mutat. Res. 417 (1998) 75-84. 1596-84-5 Succinic Acid-2,2-Dimethyl Hydrazide CN(C)NC(=O)CCC(O)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 7422-80-2 Hydrazine, 1,1-Dibutyl- CCCCN(N)CCCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 530-50-7 1,1-Diphenylhydrazine NN(c1ccccc1)c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 5802-60-8 1,1-bis(phenylmethyl)-hydrazine NN(Cc1ccccc1)Cc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 616-40-0 Hydrazine, 1,1-diethyl- CCN(N)CC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Hansen et al. J. Chem. Inf. Model., 2009, 49 (9), pp 2077–2081 4359-61-9 Diacetyl hydrazine CC(=O)N(N)C(C)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Hansen et al. J. Chem. Inf. Model., 2009, 49 (9), pp 2077–2081 366-70-1 p-Toluamide,_N-isopropyl-alpha-(2-methylhydrazino)-,_monohydrochloride; Procarbazine hydrochloride CC(C)NC(=O)c1ccc(CNNC)cc1_Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240