CAS	Chem.name	Chem.SMILES	#Observed Mutagenicity without S9	#Observed Mutagenicity with S9	Bioassay - 	Reference(s) -
86-30-6	N-Nitrosodiphenylamine	O=NN(c1ccccc1)c1ccccc1	in vitro Ames negative	in vitro Ames negative	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
1116-54-7	N-Nitrosodiethanolamine	OCCN(CCO)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
101-25-7	N,N-Dinitrosopentamethylenetetramine	O=NN1CN2CN(C1)CN(N=O)C2	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
135-20-6	Cupferron	ON(c1ccccc1)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
122341-55-3	Diazo-N-nitrosoetilefrin	CCN(CC(O)C1C=CC(=[N+]=[N-])C(=O)C=1)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	KIKUGAWA,K, KATO,T AND TAKEDA,Y;; CHEM. PHARM. BULL. 37(6):1600-1603, 1987
70-25-7	N-Methyl-N'-Nitro-N-Nitrosoguanidine	CN(N=O)C(=N)N[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
154-93-8	carmustine	O=C(NCCCl)N(CCCl)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
149573-80-8	(1-Nitroso-1h-imidazol-4-yl)acetohydroxamic acid	ONC(=O)CC1=CN(N=O)C=N1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Danno, G., et. al.; A Mutagen From Histidine Reacted With Nitrite; J. Agric. Food Chem. 41(7):1090-1093, 1993
116539-70-9	2,4-Cyclohexadien-1-one, 4-(2-(butylnitrosamino)-1-hydroxyethyl)-6-	CCCCN(CC(O)C1C=CC(=O)C(C=1)=[N+]=[N-])N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	KIKUGAWA,K. et al MUTAT. RES. 177(1):35-43, 1987
7090-25-7	Nitrosocarbaryl	CN(C(=O)Oc1cccc2ccccc12)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25
55-18-5	N-Nitrosodiethylamine	CCN(CC)N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
59-89-2	N-nitrosomorpholine	O=NN1CCOCC1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T AND MORTELMANS,K; SALMONELLA MUTAGENICITY TESTS. V. RESULTS FROM THE TESTING OF 311 CHEMICALS; ENVIRON. MOL. MUTAGEN. 19(SUPPL.21):2-141, 1992
62-75-9	N-nitrosodimethylamine	CN(C)N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
100-75-4	N-Nitrosopiperidine	O=NN1CCCCC1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	National Toxicology program. P&G Inventory
7247-89-4	Piperidine, 2-methyl-N-nitroso-	CC1CCCCN1N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240
3817-11-6	n-butyl-n-(4-hydroxybutyl)nitrosamine;4-(butylnitrosoamino)-1-butanol	CCCCN(CCCCO)N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	RUMRUEN,K AND POOL,BL; METABOLIC ACTIVATION CAPABILITIES OF S9 AND HEPATOCYTES FROM UNINDUCED RATS TO CONVERT CARCINOGENIC N-NITROSAMINES TO MUTAGENS; MUTAT. RES. 140(2-3):147-153, 1984
869-01-2	n-butyl-n-nitrosourea; 1-butyl-1-nitrosourea	CCCCN(C(N)=O)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	JANZOWSKI,C, JACOB,D, HENN,I, ZANKL,H, POOL-ZOBEL,BL, WIESSLER,M AND EISENBRAND,G;MECHANISM OF ACTION OF THE URINARY BLADDER CARCINOGEN N-NITROSOBUTYL-3-CARBOXYPROPYLAMINE; IARC SCI. PUBL. 105(RELEVANCE HUM. CANCER N-NITROSO COMPD., TOB. MYCOTOXINS):332-338, 1991
13909-09-6	Semustine; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea	CC1CCC(NC(=O)N(CCCl)N=O)CC1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Ashby, J, et. el.; Mutagenicity to Salmonella, Drosophila and the Mouse Bone Marrow of the Human Antineoplastic Agent Fotemustine: Prediction Of Carcinogenic Potency; Mutat. Res. 286(1):101- 109, 1993
55557-00-1	dinitrosohomopiperazine;1h-1,4-diazepine, hexahydro-1,4-dinitroso-	O=NN1CCCN(N=O)CC1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
140-79-4	dinitrosopiperazine	O=NN1CCN(N=O)CC1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
63885-23-4	n-ethyl-n'-nitro-n-nitroguanidine	CCN=C(N)N(N=O)[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Nakamura, S.-i., Y. Oda, Ts. Shimada, I. Oki, K. Sugimoto, SOS-Inducing Activity of Chemical Carcinogens and Mutagens in Salmonella typhimurium TA1535/pSK 1002: Examination with 151 Chemicals, Mutat. Res. 192 (1987), 239 – 246
38434-77-4	ethylnitrosocyanamide	CCN(C#N)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Lee, K., B. Gold, S. S. Mirvish, Mutagenicity of 22 N-Nitrosamides and Related Compounds for Salmonella typhimurium TA1535, Mutat. Res. 48 (1977), 131 – 138
759-73-9	1-ethyl-1-nitrosourea	CCN(C(N)=O)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Ashby, J., Tinwell, H. and Callander, Rd.; Activity of Urethane and N,N-Dimethylurethane in the Mouse Bone-Marrow Micronucleus Assay: Equivalence of Oral and Intraperitoneal Routes of Exposure; Mutat. Res. 245(3):227-230, 1990
92118-27-9	fotemustine	CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Ashby, J, et. el.; Mutagenicity to Salmonella, Drosophila and the Mouse Bone Marrow of the Human Antineoplastic Agent Fotemustine: Prediction Of Carcinogenic Potency; Mutat. Res. 286(1):101- 109, 1993
18774-85-1	n-hexylnitrosourea;urea, 1-hexyl-1-nitroso-	CCCCCCN(C(N)=O)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
13743-07-2	1-(2-hydroxyethyl)-1-nitrosourea	NC(=O)N(CCO)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
63412-06-6	n-methyl-n-nitrosobenzamide	CN(C(=O)c1ccccc1)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
33868-17-6	methylnitrosocyanamide	CN(C#N)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
38777-13-8	nitroso-baygon;n-nitrosopropoxur	CC(C)Oc1ccccc1OC(=O)N(C)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
5336-53-8	n-nitrosodibenzylamine	O=NN(Cc1ccccc1)Cc1ccccc1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
924-16-3	n,n-dibutylnitrosamine;nitrosodibutylamine	CCCCN(CCCC)N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	RUMRUEN,K AND POOL,BL; METABOLIC ACTIVATION CAPABILITIES OF S9 AND HEPATOCYTES FROM UNINDUCED RATS TO CONVERT CARCINOGENIC N-NITROSAMINES TO MUTAGENS; MUTAT. RES. 140(2-3):147-153, 1984
16813-36-8	1-nitroso-5,6-dihydrouracil	O=C1CCN(N=O)C(=O)N1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
89911-79-5	n-nitroso-2,3-dihydroxypropyl-2-hydroxypropylamine	CC(O)CN(CC(O)CO)N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	MORI,Y, YAMAZAKI,H, TOYOSHI,K, DENDA,A AND KONISHI,Y; MUTAGENIC ACTIVATION OF CARCINOGENIC N-NITROSOPROPYLAMINES BY LIVER S9 FRACTIONS FROM MICE, RATS AND HAMSTERS. EVIDENCE FOR A CYTOCHROME P-450-DEPENDENT REACTION; CARCINOGENESIS 7(3):375-379, 1986
621-64-7	N,N-dipropylnitrosamine	CCCN(CCC)N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Dahl ,Ar.; Mutagenicity Of Some Dialkylnitrosamines, Cyclic Nitrosamines And N,N-Diethanolnitrosamine In Salmonella Typhimurium With Rat And Rabbit Nasal, Lung And Liver S9 Homogenates; Mutat. Res. 158(3):141-147, 1985
614-95-9	nitrosoethylurethane	CCN(C(=O)OCC)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
42579-28-2	1-nitrosohydantoin;42579-28-2	O=C1CN(N=O)C(=O)N1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
56222-35-6	n-nitroso-3-hydroxypyrrolidine;3-hydroxy-1-nitrosopyrrolidine	OC1CCN(N=O)C1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	U.S. Environmental Protection Agency; Mutation Research, 168 (1986) 69-240
937-40-6	n-methyl-n-benzylnitrosamine	CN(Cc1ccccc1)N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	SINGER,GM, ANDREWS,AW AND GUO,SM; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP OF THE MUTAGENICITY OF SUBSTITUTED N-NITROSO-N-BENZYLMETHYLAMINES: POSSIBLE IMPLICATIONS FOR CARCINOGENICITY; J. MED. CHEM. 29(1):40-44, 1986
684-93-5	n-methyl-n-nitrosourea	CN(C(N)=O)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	OHTSUKA,M AND MAEKAWA,K; A STRAIGHT CORRELATION BETWEEN MUTAGENIC ACTIVITY AND BETA-GALACTOSIDASE ACTIVITY INDUCED BY MONOFUNCTIONAL ALKYLATING AGENTS; MUTAT. RES. 283(1):83-86, 1992
16543-55-8	(S)-N'-Nitrosonornicotine	O=NN1CCCC1c1cccnc1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Padma, P.R., Amonkar, A.J., Bhide, S.V., Mutagenic and Cytogenetic Studies of N'-Nitrosonornicotine and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone. Cancer Lett., 1989, 46(3), 173 - 180
5632-47-3	n-nitrosopiperazine	O=NN1CCNCC1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Zeiger E, Legator MS, Lijinsky W. Mutagenicity of N-nitrosopiperazines for Salmonella typhimurium in the host-mediated assay. Cancer Res. 1972 Jul;32(7):1598-9.
930-55-2	n-nitrosopyrrolidine;1-nitrosopyrrolidine;pyrrolidine, 1-nitroso-	O=NN1CCCC1	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	Guttenplan, J. B., N-Nitrosamines: Bacterial Mutagenesis and In Vitro Metabolism, Mutat. Res. 186 (1987), 81 – 134
55556-92-8	N-Nitroso-1,2,3,6-tetrahydropyridine	O=NN1CCC=CC1	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	A report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutat. Res. 168:69-240, 1986
64091-91-4	4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone	CN(CCCC(=O)c1cccnc1)N=O	in vitro Ames negative	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	ZHU,S, CUNNINGHAM,ML, GRAY,TE AND NETTESHEIM,P; CYTOTOXICITY, GENOTOXICITY AND TRANSFORMING ACTIVITY OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN RAT TRACHEAL EPITHELIAL CELLS; MUTAT. RES. 261(4):249-259, 1991
13010-07-6	Propyl-N'-nitro-N-nitrosoguanidine	CCCN(N=O)C(=N)N[N+]([O-])=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	MCCANN,J, CHOI,E, YAMASAKI,E AND AMES,BN; DETECTION OF CARCINOGENS AS MUTAGENS IN THE SALMONELLA/MICROSOME TEST: ASSAY OF 300 CHEMICALS; PROC. NATL. ACAD. SCI. USA 72(12):5135-5139, 1975
816-57-9	Propylnitrosourea	CCCN(C(N)=O)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	UKAWA-ISHIKAWA,S, SAWADA,A, KASUYA,A AND MOCHIZUKI,M; MUTAGENICITY OF ISOMERIC ALKANEDIAZOTATES, PRECURSORS FOR ULTIMATE ALKYLATING SPECIES OF CARCINOGENIC N-NITROSO COMPOUNDS; MUTAT. RES. 412(1):99-107, 1998
18883-66-4	streptozotocin	CN(C(=O)NC1C(O)C(O)C(CO)OC1O)N=O	in vitro Ames positive	in vitro Ames positive	Bacterial Reverse Mutation Assay (e.g. Ames Test)	MCCANN,J, CHOI,E, YAMASAKI,E AND AMES,BN; DETECTION OF CARCINOGENS AS MUTAGENS IN THE SALMONELLA/MICROSOME TEST: ASSAY OF 300 CHEMICALS; PROC. NATL. ACAD. SCI. USA 72(12):5135-5139, 1975