CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 75-91-2 Tert-Butyl Hydroperoxide CC(C)(C)OO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 614-45-9 Tert-Butyl Perbenzoate CC(C)(C)OOC(=O)c1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 80-15-9 cumene hydroperoxide;2-phenyl-prop-2-yl-hydroperoxide;hydroperoxide CC(C)(c1ccccc1)OO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 18774-09-9 9-Hydroperoxy-9-methylfluorene CC1(OO)c2ccccc2-c2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lavoie, EJ., et. al.; Studies on the Mutagenicity and Tumor-Initiating Activity of Methylated Fluorenes; Chem.-Biol. Interact. 52(3):301-309, 1985 38716-10-8 5-Hydroperoxymethyl-2'-deoxyuridine OCC{P+}1C{P-}(O)CC{P+}(N2C=C(COO)C(=O)NC2=O)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) PATEL,U, BHIMANI,R AND FRENKEL,K; MECHANISM OF MUTAGENICITY BY 5-HYDROPEROXYMETHYL-2'-DEOXYURIDINE, AN INTERMEDIATE PRODUCT OF IONIZING RADIATION, IN BACTERIA. HPMDU BACTERIAL MUTAGENICITY AND OXIDATION OF DNA BASES; MUTAT. RES. 283(2):145-156, 1992 2846-29-9 Cholesterol 7-hydroperoxide CC(C)CCCC(C)C1CCC2C3C(OO)C=C4CC(O)CCC4(C)C3CCC12C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SMITH,LL, SMART,VB AND GOWDA,NMM; MUTAGENIC STEROL HYDROPEROXIDES; MUTAT. RES. 161(1):39-48, 1986 3328-25-4 Cholest-6-en-3-beta-ol, 5-alpha-hydroperoxide CC(C)CCCC(C)C1CCC2C3C=CC4(CC(O)CCC4(C)C3CCC12C)OO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SMITH,LL, SMART,VB AND GOWDA,NMM; MUTAGENIC STEROL HYDROPEROXIDES; MUTAT. RES. 161(1):39-48, 1986 3031-73-0 Methyl hydroperoxide; methyl hydroperoxide;methyl-hydroperoxide;methylhydroperoxide COO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, JC, Young, WC, Wallington, TJ and Japar,SM; Mutagenic Properties of A Series of Alkyl Hydroperoxides; Environ. Sci. Technol. 26(2):397-399, 1992 6068-96-8 N-Propyl hydroperoxide; n-propyl hydroperoxide CCCOO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, JC, Young, WC, Wallington, TJ and Japar,SM; Mutagenic Properties of A Series of Alkyl Hydroperoxides; Environ. Sci. Technol. 26(2):397-399, 1992 117135-59-8 2-Butylazo-2-propyl hydroperoxide CCCCN=NC(C)(C)OO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MOCHIZUKI,M. et al BIOL. PHARM. BULL. 16(1):96-98, 1993 149127-56-0 2-Methylazo-2-propyl hydroperoxide CC(C)(N=NC)OO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MOCHIZUKI,M. et al BIOL. PHARM. BULL. 16(1):96-98, 1993 4813-50-7 n-Butylhydroperoxide; n-butyl hydroperoxide CCCCOO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, JC, Young, WC, Wallington, TJ and Japar,SM; Mutagenic Properties of A Series of Alkyl Hydroperoxides; Environ. Sci. Technol. 26(2):397-399, 1992 3031-74-1 Ethyl hydroperoxide; ethyl hydroperoxide;ethyl-hydroperoxide;ethylhydroperoxide CCOO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, JC, Young, WC, Wallington, TJ and Japar,SM; Mutagenic Properties of A Series of Alkyl Hydroperoxides; Environ. Sci. Technol. 26(2):397-399, 1992 149127-58-2 2-Propylazo-2-propyl hydroperoxide CCCN=NC(C)(C)OO in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MOCHIZUKI,M. et al BIOL. PHARM. BULL. 16(1):96-98, 1993 33973-15-8 2a,7b-Dihydro-2a,7b-dimethyl-1,2-dioxeto(3,4-b)benzofuran CC12c3ccccc3OC1(C)OO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 128753-82-2 1,2-Dioxeto(3,4-b)benzofuran, 2a,7b-dihydro-7b-methoxy-2a-methyl- CC12C(OC)(c3ccccc3O1)OO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 128753-83-3 2a,7b-Dihydro-7b-methyl-1,2-dioxeto(3,4-b)benzofuran CC12C(Oc3ccccc13)OO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 128753-86-6 4-Acetyl-2a,7b-dihydro-2a,7b-dimethyl-1,2-dioxeto(3,4-b)benzofuran CC(=O)c1cccc2c1OC1(C)C2(C)OO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 128753-87-7 2a,7b-Dihydro-7-methoxy-2a,7b-dimethyl-1,2-dioxeto(3,4-b)benzofuran CC12c3c(cccc3OC)OC1(C)OO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 128753-95-7 2a,7b-Dihydro-2a-(methoxymethyl)-7b-methyl-1,2-dioxeto(3,4-b)benzofuran CC12c3ccccc3OC1(COC)OO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 128753-96-8 2a-(Acetyloxymethyl)-2a,7b-dihydro-7b-methyl-1,2-dioxeto(3,4-b)benzofuran CC(=O)OCC12C(C)(c3ccccc3O1)OO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 128753-99-1 2a-(4-Chlorophenylcarbamoyloxymethyl)-2a,7b-dihydro-7b-methyl-1,2-dioxeto(3,4-b)benzofuran CC12c3ccccc3OC1(COC(=O)Nc1ccc(Cl)cc1)OO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 129812-24-4 2a,9b-Dihydro-2a,8,9b-trimethyl-6H-(1,2)dioxeto(3',4':4,5)furo(3,2-g)(1)benzopyran-6-one CC1=CC(=O)Oc2cc3c(cc12)C1(C)C(C)(O3)OO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W., et. al. Furocoumarin-, Naphthofuran-, and Furoquinoline-annulated 1,2-dioxetanes: synthesis, thermolysis, and mutagenicity; Liebigs Ann. Chem. (12):1227-1236, 1990 129812-26-6 7a,9a-Dihydro,1,7a,9a-trimethyl-3H-(1,2)dioxeto(3',4':4,5)furo(3,2-f)benzopyran-3-one CC1=CC(=O)Oc2ccc3c(c12)C1(C)C(C)(O3)OO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W., et. al. Furocoumarin-, Naphthofuran-, and Furoquinoline-annulated 1,2-dioxetanes: synthesis, thermolysis, and mutagenicity; Liebigs Ann. Chem. (12):1227-1236, 1990 129833-00-7 2H-(1,2)Dioxeto(3',4':4,5)furo(3,2-h)-1-benzopyran-2-one, 6b,8a-dihydro-4,6b,8a-trimethyl- CC1=CC(=O)Oc2c1ccc1c2OC2(C)C1(C)OO2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Adam, W. et. al.; Benzofuran Dioxetanes, A New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives;Liebigs Ann. Chem. (1):33-40, 1991 128753-91-3 6-(Acetyloxy)-2a,7b-dihydro-2a,7b-dimethyl-1,2-dioxeto(3,4-b)benzofuran CC(=O)Oc1ccc2c(c1)C1(C)C(C)(O2)OO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ADAM,W. et al LIEBIGS ANN. CHEM. (1):33-40, 1991 771-29-9 Tetralin hydroperoxide OOC{P-}1CCCc2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 80-47-7 p-Menthane hydroperoxide CC1CCC(C(C)(C)OO)CC1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 80-43-3 Cumene peroxide CC(C)(c1ccccc1)OOC(C)(C)c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 94-36-0 Benzoyl peroxide O=C(c1ccccc1)OOC(=O)c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 110-05-4 Di-tert-butyl peroxide CC(C)(C)OOC(C)(C)C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 78-63-7 Varox CC(C)(C)OOC(C)(C)CCC(C)(C)OOC(C)(C)C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1338-23-4 Ethyl_methyl_ketone_peroxide CC(=O)CCOOCCC(C)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Hansen et al. J. Chem. Inf. Model., 2009, 49 (9), pp 2077-2081 105-74-8 Peroxide,_bis(1-oxododecyl);_Lauroyl_peroxide; Dilauroyl peroxide CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Short-Term Testing Program in the National Cancer Institute (NCI), National Institutes of Health, US Department of Health and Human Services 6731-36-8 1,1-Bis(t-butylperoxy)-3,3,5-trimethylcyclohexane CC1CC(C)(C)CC(OOC(C)(C)C)(OOC(C)(C)C)C1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 6165-51-1 1-Phenyl-1-(2,5-xylyl)ethane CC(c1ccccc1)c1cc(C)ccc1C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan