CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 62-44-2 Phenacetin CCOc1ccc(NC(C)=O)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) S. De Flora, P. Russo, M. Pala, G. Fassina, A. Zunino, C. Bennicelli, P. Zanacchi, A. Camoirano, S. Parodi, Assay of phenacetin genotoxicity using in vitro and in vivo test systems, J. Toxicol. Environ. Health. 16 (3-4) (1985) 355-377. J.W. Oldham, R.F. Preston, J.D. Paulson, Mutagenicity testing of selected analgesics in Ames Salmonella strains, J. Appl. Toxicol. 6 (4) (1986) 237-243. 92-84-2 Phenothiazine c1cccc2c1Nc1ccccc1S2 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 101-72-4 N-Isopropyl-N'-phenyl-para-phenylenediamine CC(C)Nc1ccc(Nc2ccccc2)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 103-90-2 Acetaminophen CC(=O)Nc1ccc(O)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 122-39-4 N,N-Diphenylamine c1ccccc1Nc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 793-24-8 N-(1,3-Dimethylbutyl)-N'-Phenyl-P-Phenylenediamine CC(C)CC(C)Nc1ccc(Nc2ccccc2)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 3846-71-7 2-(2'-Hydroxy-3',5'-di-tert-butylphenyl)benzotriazole CC(C)(C)c1cc(C(C)(C)C)cc(N2N=C3C=CC=CC3=N2)c1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 95-70-5 2-Methyl-Benzene-1,4-Diamine Cc1cc(N)ccc1N in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 105-11-3 P-Benzoquinone_Dioxime ON=C1C=CC(=NO)C=C1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 94-52-0 6-Nitrobenzimidazole [O-][N+](=O)c1ccc2[nH]cnc2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 72917-35-2 1,4-Dimethyl-6-Hydroxy-3-Nitrocarbazole Cc1cc(c(C)c2c3cc(O)ccc3[nH]c12)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 129117-54-0 1,4-Dimethyl-6-Methoxy-3-Aminocarbazole Cc1cc(N)c(C)c2c1Nc1ccc(OC)cc-21 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 6358-07-2 2-Amino-4-Chloro-5-Nitrophenol Nc1cc(Cl)c(cc1O)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 61702-44-1 2-Chloro-p-phenylenediamine sulfate Nc1ccc(N)cc1Cl_OS(O)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 581-64-6 Thionine NC1=CC2C(C=C1)=Nc1ccc(N)cc1S{+}=2.Cl{-} in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 39156-41-7 2,4-Diaminoanisole sulfate COc1ccc(N)cc1N_OS(O)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 220042-15-9 2-(4-Nitrophenylamino)-5-(3-benzoylamino-2,4,5-thiadiazolyl)-1,4-benzoquinone OC1=CC(=Nc2ccc(cc2)[N+]([O-])=O)C(=O)C=C1c1nnc(NC(=O)c2ccccc2)s1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HASSAN,MA. et al ARCH. PHARM. 331(12):385-388, 1998 55-55-0 N-methyl-p-aminophenol sulfate CNc1ccc(O)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 74-31-7 N,N'-Diphenyl-P-Phenylenediamine c1ccccc1Nc1ccc(Nc2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 102-50-1 m-Cresidine Cc1cc(OC)ccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 137-09-7 2,4-Diaminophenol Nc1ccc(O)c(N)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 156-10-5 p-Nitrosodiphenylamine O=Nc1ccc(Nc2ccccc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 609-20-1 2,6-Dichloro-benzene-1,4-diamine Nc1cc(Cl)c(N)c(Cl)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 2735-04-8 Aniline, 2,4-Dimethoxy- COc1ccc(N)c(OC)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 6219-89-2 4-Amino-4'-Hydroxy-3-Methyldiphenylamine Cc1cc(Nc2ccc(O)cc2)ccc1N in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 15893-52-4 2H-1,4-Benzoxazin-3(4H)-one, 2,4-Dihydroxy-7-Methoxy- COc1ccc2c(c1)OC(O)C(=O)N2O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 93-46-9 Diafen NN; 1,4-Bis(2-naphthylamino)benzene c1cccc2ccc(Nc3ccc(Nc4ccc5ccccc5c4)cc3)cc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) P&G 86-42-0 Amodiaquine CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Chatterjee, T., A. Muhkopadhyay, K. A. Khan, A. K. Giri, Comparative Mutagenic and Genotoxic Effects of Three Antimalarial Drugs, Chloroquine, Primaquine and Amodiaquine, Mutagen. 13(6) (1998), 619 - 624 61-73-4 Methylene Blue CN(C)C1=CC2C(C=C1)=Nc1ccc(N(C)C)cc1S{+}=2.Cl{-} in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHORT-TERM TEST PROGRAM SPONSORED BY THE DIVISION OF CANCER BIOLOGY, NATIONAL CANCER INSTITUTE, MS. ELLEN ZAIKA, ASSISTANT PROJECT OFFICER , p. Y88 33203-82-6 C.I. Basic Blue 3 CCN(CC)c1ccc2c(c1)OC1=CC(=N{+}(.Cl{-})(CC)CC)C=CC1=N2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Basic Blue 3, Toxicology Data Network, U.S. National Library of Medicine; https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+ccris:@term+@rn+33203-82-6