CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 69314-47-2 3-Methyl-4-Nitro-Biphenyl Cc1cc(ccc1[N+]([O-])=O)-c1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 117-39-5 Quercetin Oc1ccc(C2=C(O)C(=O)c3c(cc(O)cc3O)O2)cc1O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 53-95-2 N-Hydroxy-2-Acetylaminofluorene CC(=O)N(O)c1ccc2c(Cc3ccccc-23)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1986) pp. 69-240 2058-02-8 2-Anthracenecarboxylic_Acid,_9,10-Dihydro-1-Amino-9,10-Dioxo-4-Nitro- Nc1c(cc(c2C(=O)c3ccccc3C(=O)c12)[N+]([O-])=O)C(O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 105-11-3 P-Benzoquinone_Dioxime ON=C1C=CC(=NO)C=C1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 81-49-2 1-Amino-2,4-Dibromo_Anthraquinone Nc1c(Br)cc(Br)c2c1C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 81-55-0 1,8-Dihydroxy-4,5-Dinitroanthraquinone Oc1ccc(c2C(=O)c3c(ccc(O)c3C(=O)c12)[N+]([O-])=O)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 84-65-1 9,10-Anthraquinone O=C1c2ccccc2C(=O)c2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 116-85-8 1-Amino-4-Hydroxyanthraquinone Nc1ccc(O)c2c1C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 117-05-5 1-Benzamido-5-Chloroanthraquinone O=C(c1ccccc1)Nc1cccc2c1C(=O)c1cccc(Cl)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 117-12-4 Anthraquinone,_1,5-Dihydroxy- Oc1cccc2c1C(=O)c1cccc(O)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 145-49-3 1,5-Dihydroxy-4,8-Diaminoanthraquinone Nc1ccc(O)c2c1C(=O)c1c(O)ccc(N)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1758-68-5 1,2-Diamino-Anthraquinone Nc1ccc2c(c1N)C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 577-33-3 1,2,10-Anthracenetriol Oc1ccc2c(cc3ccccc3c2O)c1O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 602-64-2 Anthraquinone,_1,2,3-Trihydroxy- Oc1cc2c(c(O)c1O)C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 6483-86-9 6-Anthracenesulfonic_Acid,_9,10-Dihydro-9,10-Dioxo-1-Nitro- OS(=O)(=O)c1ccc2C(=O)c3c(cccc3[N+]([O-])=O)C(=O)c2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 81-54-9 1,2,4-Trihydroxyanthraquinone Oc1cc(O)c(O)c2c1C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 82-33-7 1,4-Diamino-5-Nitroanthraquinone Nc1ccc(N)c2C(=O)c3c(cccc3[N+]([O-])=O)C(=O)c12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 82-50-8 5-Anthracenesulfonic_Acid,_9,10-Dihydro-9,10-Dioxo-1-Nitro- OS(=O)(=O)c1cccc2C(=O)c3c(cccc3[N+]([O-])=O)C(=O)c12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 481-72-1 Anthraquinone,_1,8-Dihydroxy-3-Hydroxymethyl- OCc1cc(O)c2c(c1)C(=O)c1cccc(O)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2475-45-8 1,4,5,8-Tetraaminoanthraquinone; Disperse_Blue_1 Nc1ccc(N)c2c1C(=O)c1c(N)ccc(N)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 6358-07-2 2-Amino-4-Chloro-5-Nitrophenol Nc1cc(Cl)c(cc1O)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 16048-37-6 1-Anthracenediazonium, 9,10-dihydro-9,10-dioxo-, chloride N#N{+}(.Cl{-})c1cccc2c1C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 28860-95-9 Carbidopa CC{P+}(Cc1ccc(O)c(O)c1)(C(O)=O)NN in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) KITAMURA,J. RES. COMMUN. CHEM. PATHOL. PHARMACOL. 49(3):415-422, 1985 613-13-8 2-Anthracenamine Nc1ccc2cc3ccccc3cc2c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Diehl, M. And Fort, F.; Spiral Salmonella Assay: Validation Against The Standard Pour-Plate Assay; Environ. Mol. Mutagen. 27(3):227-236, 1996 475-38-7 Naphthazarin Oc1ccc(O)c2c1C(=O)C=CC2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HAKURA,A, et.al.; MUTAGENICITY AND CYTOTOXICITY OF NAPHTHOQUINONES FOR AMES SALMONELLA TESTER STRAINS; CHEM. RES. TOXICOL. 7(4):559-567, 1994 68217-36-7 1,4-Naphthalenedione, 5-amino-8-hydroxy- Nc1ccc(O)c2c1C(=O)C=CC2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MEDINA,LFC, et.al.; GENOTOXICITY OF AMINOHYDROXYNAPHTHOQUINONES IN BACTERIA, YEAST, AND CHINESE HAMSTER LUNG FIBROBLAST CELLS. MUTAT. RES., GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS. 650(2): 140-149, 2008 481-42-5 Plumbagin CC1=CC(=O)c2c(O)cccc2C1=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HAKURA,A, et.al.; MUTAGENICITY AND CYTOTOXICITY OF NAPHTHOQUINONES FOR AMES SALMONELLA TESTER STRAINS; CHEM. RES. TOXICOL. 7(4):559-567, 1994 128-95-0 9,10-Anthracenedione Nc1ccc(N)c2c1C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996 3602-55-9 2-tert-Butyl-4-quinone CC(C)(C)C1=CC(=O)C=CC1=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 106-51-4 1,4-Benzoquinone O=C1C=CC(=O)C=C1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) LIN,JK AND LEE,SF; ENHANCEMENT OF THE MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND NITROSATION IN SALMONELLA TYPHIMURIUM; MUTAT. RES. 269(2): 217-224, 1992; 481-39-0 Juglone Oc1cccc2c1C(=O)C=CC2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 84-58-2 Dichlorodicyanobenzoquinone N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HAKURA,A, et.al.; MUTAGENICITY OF BENZOQUINONES FOR AMES SALMONELLA TESTER STRAINS; MUTAT. RES. 347(1):37-43, 1994 112022-05-6 n-[2-(dimethylamino)ethyl]-1-anthracenecarboxamide CN(C)CCNC(=O)c1cccc2cc3ccccc3cc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 112022-06-7 n-[2-(dimethylamino)ethyl]-9,10-dihydro-9,10-dioxo-1-anthracenecarboxamide CN(C)CCNC(=O)c1cccc2c1C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Denny, Wa., et. al.; Structure- Activity Relationships For The Mutagenic Activity Of Tricyclic Intercalating Agents In Salmonella Typhimurium; Mutat. Res. 232(2):233-241, 1990 10048-13-2 Sterigmatocystin COc1cc2c(C3C=COC3O2)c2c1C(=O)c1c(cccc1O)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2798-25-6 bellidifolin COc1cc2c(c(O)c1)C(=O)c1c(O)ccc(O)c1O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 2980-32-7 desmethylbellidifolin Oc1ccc(O)c2c1C(=O)c1c(cc(O)cc1O)O2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 5557-27-7 dimethylbellidifolin COc1ccc(O)c2c1Oc1cc(OC)cc(OC)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-53-6 Austocystin d CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(c(O)c1C2=O)C1(O)C=COC1O3 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) KFIR,R, JOHANNSEN,E AND VLEGGAAR,R; BULL. ENVIRON. CONTAM. TOXICOL. 37(5):643650, 1986 55256-55-8 austocystin c CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(C4C=COC4O3)c(OC)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 55256-57-0 austocystin b CC(C)(O)CCc1ccc(O)c2c1Oc1cc3c(C4C=COC4O3)c(O)c1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 138154-39-9 5-((2-diethylamino)ethyl)amino)-8-hydroxy-6h-imidazo(4,5,1-de)acridin-6-one;c 1311 CCN(CC)CCNc1ccc2c3c1C(=O)c1cc(O)ccc1N3C=N2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Berger, B., Marquardt, H. and Westendorf, J.; Pharmacological and Toxicological Aspects of new Imidazoacridinone Antitumor Agents; Cancer Res. 56(9):2094-2104, 1996 138154-40-2 5-((2-(diethylamino)ethyl)amino)-8-hydroxy-1-methyl-6h-imidazo(4,5,1-de)acidin-6-one;c 1310 CCN(CC)CCNc1ccc2c3c1C(=O)c1cc(O)ccc1N3C(C)=N2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Berger, B., Marquardt, H. and Westendorf, J.; Pharmacological and Toxicological Aspects of new Imidazoacridinone Antitumor Agents; Cancer Res. 56(9):2094-2104, 1996 482-35-9 isoquercetin;quercetin-3-glucoside OCC1C(O)C(O)C(O)C(OC2=C(c3ccc(O)c(O)c3)Oc3cc(O)cc(O)c3C2=O)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 90-44-8 9(10h)-anthracenone;anthrone;anthracen-9(10h)-one O=C1c2ccccc2Cc2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 3022-61-5 10-acetyl dithranol;acdithr10 CC(=O)C1c2cccc(O)c2C(=O)c2c1cccc2O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 75464-10-7 10-propionyl dithranol CCC(=O)C1c2cccc(O)c2C(=O)c2c1cccc2O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 75464-11-8 butantrone CCCC(=O)C1c2cccc(O)c2C(=O)c2c1cccc2O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 121111-59-9 2-(2,4-dimethylphenyl)-4,5-bis(4-methylphenyl)-1h-imidazole Cc1ccc(C2=C(c3ccc(C)cc3)NC(c3ccc(C)cc3C)=N2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MERCANGOZ,A AND TUYLU,BA;TURK. J. BIOL. 24(1):5764, 2000 7044-99-7 2-phenyl-4,5-bis(4-methoxyphenyl)-1h-imidazole COc1ccc(C2=C(c3ccc(OC)cc3)NC(c3ccccc3)=N2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 121111-61-3 2-(3,4-dimethoxyphenyl)-4,5-bis(4-methylphenyl)-1h-imidazole Cc1ccc(C2=C(c3ccc(C)cc3)NC(c3ccc(OC)c(OC)c3)=N2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MERCANGOZ,A AND TUYLU,BA;TURK. J. BIOL. 24(1):5764, 2000 125701-97-5 2-(2,4-dimethylphenyl)-4,5-bis(4-methoxyphenyl)-1h-imidazole Cc1ccc(C2NC(c3ccc(OC)cc3)=C(c3ccc(OC)cc3)N=2)c(C)c1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MERCANGOZ,A AND TUYLU,BA;TURK. J. BIOL. 24(1):5764, 2000 1728-96-7 2,4,5-tris(4-methoxyphenyl)-1h-imidazole COc1ccc(C2=C(c3ccc(OC)cc3)NC(c3ccc(OC)cc3)=N2)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 6151-25-3 Quercetin dihydrate O_O_Oc1ccc(C2=C(O)C(=O)c3c(cc(O)cc3O)O2)cc1O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 500733-87-9 5-Amino-2,8-Dihydroxy-1,4-Naphthoquinone Nc1ccc(O)c2c1C(=O)C=C(O)C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) daCosta Medina, L. F., C. M. Viau, D. J. Moura, J. Saffi, V. Stefan, A. Brandelli, J. A. Henriques, Genotoxicity of Aminohydroxynaphthoquinones in Bacterial, Yeast, and Chinese Hamster Lung Fibroblast Cells, Mutat. Res. 650 (2008), 140 - 149. 117-80-6 Dichlone O=C1c2ccccc2C(=O)C(Cl)=C1Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hakura, A., H. Mochida, Y. Tsdutsui, K. Yamatsu, Mutagenicty and Cytotoxicity of Naphthoquinones for Ames Salmonella Tester Strains, Chem. Res. Toxicol. 7 (1994), 559 - 567 524-42-5 1,2-Naphthoquinone O=C1C=Cc2ccccc2C1=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 130-15-4 1,4-Naphthoquinone O=C1C=CC(=O)c2ccccc12 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hakura, A., H. Mochida, Y. Tsdutsui, K. Yamatsu, Mutagenicty and Cytotoxicity of Naphthoquinones for Ames Salmonella Tester Strains, Chem. Res. Toxicol. 7 (1994), 559 - 567 14918-69-5 2,3-Dichloro-5,8-Dihydroxy-1,4-Naphthoquinone Oc1ccc(O)c2c1C(=O)C(Cl)=C(Cl)C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hakura, A., H. Mochida, Y. Tsdutsui, K. Yamatsu, Mutagenicty and Cytotoxicity of Naphthoquinones for Ames Salmonella Tester Strains, Chem. Res. Toxicol. 7 (1994), 559 - 567 58-27-5 Menadione CC1=CC(=O)c2ccccc2C1=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K; MUTAGENICITY AND CYTOTOXICITY OF NAPHTHOQUINONES FOR AMES SALMONELLA TESTER STRAINS; CHEM. RES. TOXICOL. 7(4):559-567, 1994 7090-25-7 Nitrosocarbaryl CN(C(=O)Oc1cccc2ccccc12)N=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1836-75-5 Nitrofen Nc1cc(Cl)c(cc1O)[N+]([O-])=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 478-08-0 lucidin OCc1c(O)cc2c(c1O)C(=O)c1ccccc1C2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S. Environmental Protection Agency, Mutation Research, 168 (1996) 69-240 51-30-9 Isoproterenol Hydrochloride CC(C)NCC(O)c1ccc(O)c(O)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 83-72-7 2-Hydroxy-1,4-Naphthoquinone OC1=CC(=O)c2ccccc2C1=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 117-79-3 2-Amino-anthraquinone Nc1ccc2c(c1)C(=O)c1ccccc1C2=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 120-12-7 Anthracene c1cccc2cc3ccccc3cc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 131-14-6 Anthraquinone, 2,6-Diamino- Nc1ccc2c(c1)C(=O)c1ccc(N)cc1C2=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 610-49-1 1-Anthracenamine Nc1cccc2cc3ccccc3cc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 842-07-9 C.I. Solvent Yellow 14 Oc1ccc2ccccc2c1N=Nc1ccccc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1126-61-0 1,2-Benzenediol,_4-(2-propenyl)- C=CCc1ccc(O)c(O)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1421-63-2 2,4,5-Trihydroxybutyrophenone CCCC(=O)c1cc(O)c(O)cc1O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 2150-60-9 Sodium 4,8-diamino-9,10-dihydro-1,5-dihydroxy-9,10-dioxoanthracene-2-sulphonate Nc1ccc(O)c2c1C(=O)c1c(C2=O)c(N)cc(S(O)(=O)=O)c1O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 2646-17-5 Solvent Orange 2 Cc1ccccc1N=Nc1c2ccccc2ccc1O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 19315-64-1 Acetohydroxamic acid, N-(4-Ethoxyphenyl)- CCOc1ccc(N(O)C(C)=O)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 29743-15-5 4-Butyloxybenzal-4-Ethlaniline CCCCOc1ccc(C=Nc2ccc(CC)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 98911-07-0 Acetamide, N-(4-(4-chlorophenoxy)phenyl)-N-hydroxy- CC(=O)N(O)c1ccc(Oc2ccc(Cl)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Miyauchi, M., Endoh, Y. and Uematsu, T.; Mutagenic activity of the amido derivatives and their hydroxamic acids of nitrobiphenyl ethers; Bull. Environ. Contam. Toxicol. 55(3):446-452, 1995 98911-08-1 Acetamide, N-(4-(2,4-dichlorophenoxy)phenyl)-N-hydroxy- CC(=O)N(O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MIYAUCHI,M, ENDOH,Y AND UEMATSU,T; MUTAGENIC ACTIVITY OF THE AMIDO DERIVATIVES AND THEIR HYDROXAMIC ACIDS OF NITROBIPHENYL ETHERS; BULL. ENVIRON. CONTAM. TOXICOL. 55(3):446-452, 1995 108-46-3 Resorcinol Oc1cccc(O)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HOSONO,A, MAKINO,K AND OTANI,H; MUTAGENICITY OF RESORCINOL FORMED BY THE REACTION OF M-PHENYLENEDIAMINE WITH SODIUM NITRITE; J. AGRIC. FOOD CHEM. 39(10):1817-1819, 1991 82-45-1 1-Aminoanthraquinone Nc1cccc2c1C(=O)c1ccccc1C2=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 13936-21-5 9,10-Anthracenedione, 2-pentyl- CCCCCc1ccc2c(c1)C(=O)c1ccccc1C2=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 118-75-2 Chloranil O=C1C(Cl)=C(Cl)C(=O)C(Cl)=C1Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) HAKURA,A, et. al.; MUTAGENICITY OF AMES SALMONELLA TESTER STRAINS; MUTATION RESEARCH 347(1995) 37-43 2675-77-6 Chloroneb COc1cc(Cl)c(OC)cc1Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ZEIGER,E, et. al.; SALMONELLA MUTAGENICITY TESTS. V. RESULTS FROM THE TESTING OF 311 CHEMICALS; ENVIRON. MOL. MUTAGEN. 19(SUPPL.21):2-141, 1992 51489-62-4 N-(4-(4-Chlorophenoxy)phenyl)formamide O=CNc1ccc(Oc2ccc(Cl)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) M. Miyauchi, Y. Endoh and T. Uematsu, Bull. of Environ. Contam. Toxicol.,1995 55(3), 446-454 23214-92-8 Doxorubicin; Adriamycin semiquinone CC1C(O)C(N)CC(OC2CC(O)(C(=O)CO)Cc3c2c(O)c2c(c3O)C(=O)c3cccc(OC)c3C2=O)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Cebula,Ta.; Genetic And Physiological Modulation Of Anthracycline-Induced Mutagenesis In Salmonella Typhimurium; Environ. Mutagen. 8(5):675-692, 1986 135-68-2 4-Amino-4'-chlorodiphenyl Nc1ccc(-c2ccc(Cl)cc2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Sinsheimer,JE, Hooberman,BH, DAS,SK, BREZZELL,MD AND YOU,Z; THE IN VIVO AND IN VITRO GENOTOXICITY OF AROMATIC AMINES IN RELATIONSHIP TO THE GENOTOXICITY OF BENZIDINE; MUTAT. RES. 268(2):255-264, 1992 404-86-4 capsaicin;6-nonenamide, n- (4-hydroxy-3-methoxyphenyl)meth CC(C)C=CCCCCC(=O)NCc1ccc(O)c(OC)c1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Reilly, Chr., W. J. Ehlhardt, D. A. Jackson, P. Kulanthaivel, A. E. Mutlib, R. J. Espina, D. E. Moody, D. J. Crouch, G. S. Yost, Metabolism of Capsaicin by Cytochrome P450 Produces Novel Dehydrogenated Metabolites and Decreases Cytotochicity to Lung and Liver Cells, Chem. Res. Toxicol. 16 (2003), 336 – 349 63-25-2 carbaryl; 1-naphthalenol, methylcarbamate CNC(=O)Oc1cccc2ccccc12 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GROVER,IS, LADHAR,SS AND RANDHAWA,SK; CARBARYL-A SELECTIVE GENOTOXICANT; ENVIRON. POLLUT. 58(4):313-23, 1989 82-28-0 1-amino-2-methylanthraquinone;1-amino-2-methyl-9,10-anthracenedione Cc1ccc2c(c1N)C(=O)c1ccccc1C2=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MARRS,TC, COLGRAVE,HF, CROSS,NL, EDGINTON,JAG AND MORRIS BC; INHALATION TOXICITY OF A COLOURED SMOKE AND THE MUTAGENICITY OF ITS CONSTITUENT DYES, SOLVENT YELLOW 33 (CI 47,000) AND DISPERSE ORANGE 11 (CI 60,700) IN THE AMES TEST; J. HAZARD. MATER. 17(3):269-285, 1988 20830-81-3 Daunomycin CC1C(O)C(N)CC(OC2CC(O)(C(C)=O)Cc3c2c(O)c2c(c3O)C(=O)c3cccc(OC)c3C2=O)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Cebula,Ta.; Genetic And Physiological Modulation Of Anthracycline-Induced Mutagenesis In Salmonella Typhimurium; Environ. Mutagen. 8(5):675-692, 1986 518-82-1 emodin Cc1cc(O)c2c(c1)C(=O)c1cc(O)cc(O)c1C2=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) WESTENDORF,J, MARQUARDT,H, POGINSKY,B, DOMINIAK,M, SCHMIDT,J AND MARQUARDT,H; GENOTOXICITY OF NATURALLY OCCURRING HYDROXYANTHRAQUINONES; MUTAT. RES. 240(1): 1-12, 1990 520-18-3 kaempferol; 3,5,7-trihydroxy-2-(4-hydroxy-phenyl)-chromen-4-one Oc1ccc(C2=C(O)C(=O)c3c(cc(O)cc3O)O2)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHORT-TERM TEST PROGRAM SPONSORED BY THE DIVISION OF CANCER BIOLOGY, NATIONAL CANCER INSTITUTE, MS. ELLEN ZAIKA, ASSISTANT PROJECT OFFICER , p. Y86 71628-96-1 Menogaril;menogarol CC1(O)CC(OC)c2c(C1)cc1c(c2O)C(=O)c2c(O)cc3c(c2C1=O)OC1C(O)C(N(C)C)C(O)C3(C)O1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SHIBUYA,T, TAKATORI,K, SAKAMOTO,K, SASAKI,A, TANAKA,N, YAMAKAGE,K, SASAKI,K, IZUMI,J, HORIYA,N, KATOH,M, HARA,T, SEKINO,S, SAEGUSA,K, MATSUKI,Y AND MARUYAMA,Y; MUTAGENICITY STUDIES OF MENOGARIL; IYAKUHIN KENKYU 28(1):12-22, 1997 50-07-7 mitomycin-c CC1=C(N)C(=O)C2C(COC(N)=O)C3(OC)C4C(CN3C=2C1=O)N4 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SAKAMOTO,Y, FUJIKAWA,K, NAGAYABU,O, YAMAMOTO,KS AND SAMEJIMA,K; TRIPLE SHORT-TERM TESTS WITH BACTERIA AND DROSOPHILA FOR ASSESSMENT OF MUTAGENICITY OF ANTINEOPLASTICS; TAKEDA KENKYUSHOHO 44(1/2):96-116, 1985 50-65-7 Niclosamide Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ESPINOSA-AGUIRRE,JJ, SANTOS,JR AND DE NAVA,CC; INFLUENCE OF THE UVR REPAIR SYSTEM ON THE MUTAGENCIITY OF ANTIPARASITIC DRUGS; MUTAT. RES. 222(3):161-166, 1989 90-43-7 2-phenylphenol Oc1ccccc1-c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Ortho-Phenylphenol and Its Sodium Salt, IARC Monographs Volume 73 (1999), 451; http://monographs.iarc.fr/ENG/Monographs/vol73/mono73.pdf) 87-66-1 pyrogallol (1,2,3-trihydroxybenzene) Oc1cccc(O)c1O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lin,JK and Lee,SF; ENHANCEMENT OF THE MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND NITROSATION IN SALMONELLA TYPHIMURIUM; MUTAT. RES. 269(2): 217-224, 1992 533-73-3 1,2,4-trihydroxybenzene; 1,2,4-benzenetriol Oc1ccc(O)cc1O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lin,JK and Lee,SF; ENHANCEMENT OF THE MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND NITROSATION IN SALMONELLA TYPHIMURIUM; MUTAT. RES. 269(2): 217-224, 1992 69866-21-3 Rachelmycin; CC-1065 CC1=CNC2=C1C13CC1CN(C(=O)C1=Cc4c5CCN(C(=O)C6=Cc7c8CCN(C(N)=O)c8c(O)c(OC)c7N6)c5c(O)c(OC)c4N1)C3=CC2=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) 2416-94-6 2,3,6-trimethylphenol Cc1ccc(C)c(C)c1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 53-86-1 Indomethacin CC1=C(CC(O)=O)c2cc(OC)ccc2N1C(=O)c1ccc(Cl)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 59-50-7 Chlorocresol Cc1cc(O)ccc1Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 80-05-7 4,4'-Isopropylidenediphenol CC(C)(c1ccc(O)cc1)c1ccc(O)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 89-72-5 2-sec-Butylphenol CCC(C)c1ccccc1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-48-7 O-Cresol Cc1ccccc1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 95-95-4 2,4,5-Trichlorophenol Oc1cc(Cl)c(Cl)cc1Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 106-43-4 4-Chlorotoluene Cc1ccc(Cl)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 108-39-4 m-Cresol Cc1cccc(O)c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 108-95-2 Phenol Oc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 118-79-6 2,4,6-Tribromophenol Oc1c(Br)cc(Br)cc1Br in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 120-80-9 1,2-Benzenediol; Catechol Oc1ccccc1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 120-83-2 2,4-Dichlorophenol Oc1ccc(Cl)cc1Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 121-79-9 Propyl gallate CCCOC(=O)c1cc(O)c(O)c(O)c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 123-31-9 p-Hydroquinone Oc1ccc(O)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 149-91-7 Gallic_Acid Oc1cc(C(O)=O)cc(O)c1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 476-66-4 Ellagic_Acid Oc1cc2c3c(c1O)OC(=O)c1cc(O)c(O)c(c-31)OC2=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 517-28-2 Hematoxylin Oc1ccc2C3c4cc(O)c(O)cc4CC3(O)COc2c1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1143-38-0 1,8-Dihydroxyanthrone Oc1cccc2Cc3cccc(O)c3C(=O)c12 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1570-64-5 P-Chloro-O-Cresol; 4-Chloro-2-Methyl-Phenol Cc1cc(Cl)ccc1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 1948-33-0 Tert-Butyl_Hydroquinone CC(C)(C)c1cc(O)ccc1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 80830-42-8 Rentiapril Oc1ccccc1C{P-}1N(C(=O)CCS)C{P+}(C(O)=O)CS1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 82654-98-6 Vanillyl butyl ether CCCCOCc1ccc(O)c(OC)c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) The EFSA Journal(2008) 637, 1-69 2581-34-2 4-Nitro-3-cresol Cc1cc(O)ccc1[N+]([O-])=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 88-60-8 2-(1,1-Dimethylethyl)-5-methylphenol Cc1ccc(C(C)(C)C)c(O)c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 88-18-6 2-tert-Butylphenol CC(C)(C)c1ccccc1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 620-17-7 3-Ethylphenol CCc1cccc(O)c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 92-88-6 [1,1'-biphenyl]-4,4'-diol Oc1ccc(-c2ccc(O)cc2)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 620-92-8 ,4'-Methylenebis(phenol) Oc1ccc(Cc2ccc(O)cc2)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 99-71-8 Phenol,_4-(1-methylpropyl)- CCC(C)c1ccc(O)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 80-09-1 Bisphenol S Oc1ccc(S(=O)(=O)c2ccc(O)cc2)cc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 132-27-4 O-Phenylphenate_Sodium [Na]{+}.O{-}c1ccccc1-c1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 25154-52-3 CCCCCCCCCc1ccccc1O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan