CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 1072-53-3 1,3,2-Dioxathiolane,_2,2-dioxide; 1,2-Ethylenesulfate O=S1(=O)OCCO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 55-98-1 Myleran CS(=O)(=O)OCCCCOS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 62-50-0 Ethyl Methanesulfonate CCOS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 64-67-5 Diethyl_Sulfate CCOS(=O)(=O)OCC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 66-27-3 Methyl Methanesulfonate COS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 77-78-1 dimethyl_sulfate COS(=O)(=O)OC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Skopek, T.R.,et al Proc. Natl. Acad. Sci. (U.S.A.), 1978, 75(9), 4465-4469 80-40-0 Benzenesulfonic_acid,_4-methyl-,_ethyl_ester CCOS(=O)(=O)c1ccc(C)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al , Mutat Res., 2005, 581(1-2):23-34 515-46-8 Ethyl benzenesulfonate CCOS(=O)(=O)c1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 599-91-7 Propyl p-toluenesulfonate CCCOS(=O)(=O)c1ccc(C)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 926-06-7 Isopropyl methanesulfonate CC(C)OS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 1073-05-8 1,3,2-dioxathiane_2,2-dioxide; 1,3-propylene sulfate O=S1(=O)OCCCO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 1120-71-4 1,2-oxathiolane,_2,2-dioxide O=S1(=O)CCCO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 1633-83-6 1,2-Oxathiane,_2,2-dioxide; 1,4-Butane sultone O=S1(=O)CCCCO1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 1912-31-8 n-Propyl methanesulfonate CCCOS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 2307-69-9 Isopropyl toluene-4-sulphonate CC(C)OS(=O)(=O)c1ccc(C)cc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 4426-50-0 1,3-Butanediol,_cyclic_sulfate CC1CCOS(=O)(=O)O1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 16156-53-9 2-Methylpropyl methanesulfonate CC(C)COS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 16156-54-0 2-Butyl methanesulfonate CCC(C)OS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 16156-55-1 Isopentyl methanesulfonate CC(C)CCOS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 50599-13-8 (S)-2-Butyl methanesulfonate CCC{P+}(C)OS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 66194-68-1 (R)-2-Butyl methanesulfonate CCC{P-}(C)OS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ball, J.C., I.T. Salmeen, S.M. Morris, Environ. Mol. Mutagen., 1989, 13(2):100-6. 6165-76-0 Propargyl p-toluenesulfonate; p-Toluenesulfonic acid, 2-propynyl ester Cc1ccc(S(=O)(=O)OCC#C)cc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glowienke, S., et al, Mutat Res., 2005, 581(1-2):23-34 24698-43-9 Benzenesulfonic acid isobutyl ester CC(C)COS(=O)(=O)c1ccccc1 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) GLOWIENKE,S, FRIAUFF,W, ALLMENDINGER,T, MARTUS,HJ, SUTER,W AND MUELLER,L; STRUCTURE-ACTIVITY CONSIDERATIONS AND IN VITRO APPROACHES TO ASSESS THE GENOTOXICTY OF 19 METHANE-, BENZENE- AND TOLUENESULFONIC ACID ESTERS; MUTAT. RES. 581(1-2):23-34, 2005 299-75-2 Treosulfan CS(=O)(=O)OCC(O)C(O)COS(C)(=O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Zeiger, E., Pagano, D.A., Mutagenicity of the Human Carcinogen Treosulphan in Salmonella. Environ. Mol. Mutagen., 1989, 13(4), 343 - 346 20020-27-3 Methanesulfonic acid, 2-phenylethyl ester CS(=O)(=O)OCCc1ccccc1 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Eder, E., Kutt, W., Deininger C., In vitro induction of micronuclei by monofunctional methanesulphonic acid esters: possible role of alkylation mechanisms. Chem. Biol. Interact., 2006, 164(1-2), 76-84; Eder, E., Kütt, W., The dependence of the mutagenicity of methanesulphonic acid esters in S. typhimurium TA100 on the alkylation mechanism. Chem. Biol. Interact., 1989, 69(1), 45-59