CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 120-78-5 2,2'-Dithiobisbenzothiazole c1cccc2c1N=C(SSC1=Nc3ccccc3S1)S2 in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 19246-18-5 Cysteinylglycine NC{P-}(CS)C(=O)NCC(O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Stark, A.A., A. Arad, S. Siskindovich, D. A. Pagano, E. Zeiger, Mutation Research, 1989, 224(1), 89-94. 3411-58-3 Ethyl cysteine CCOC(=O)C(N)CS in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 52-67-5 Penicillamine CC(C)(S)C{P-}(N)C(O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glatt, H., F. Oesch , Mutagenicity of cysteine and penicillamine and its enantiomeric selectivity, Biochem Pharmacol., 1985, 34(20):3725-8 52-90-4 L-Cysteine, Cysteine NC{P-}(CS)C(O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glatt, H., Mutagenesis, 1989, 4(3), 221-227. 52-89-1 L-Cysteine_hydrochloride Cl_NC{P-}(CS)C(O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Ishidate Jr., et al Food and Chemical Toxicology, 22, 1984, 623-636. 137-30-4 Ziram CN(C)C(=S)S{-}.[Zn]{2+}.S{-}C(=S)N(C)C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hedenstedt, A., U. Rannug, C. Ramel, C. A. Wachtmeister, Mutagenicity and Metabolism Studies on 12 Thiuram and Dithiocarbamate Compounds Used as Accelerators in the Swedish Rubber Industry, Mutat. Res. 68(4), (1979), 313 - 325. 14239-68-0 Cadmium N,N-diethyldithiocarbamate CCN(CC)C(=S)S{-}.[Cd]{2+}.S{-}C(=S)N(CC)CC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hedenstedt, A., U. Rannug, C. Ramel, C. A. Wachtmeister, Mutagenicity and Metabolism Studies on 12 Thiuram and Dithiocarbamate Compounds Used as Accelerators in the Swedish Rubber Industry, Mutat. Res. 68(4), (1979), 313 - 325. 14324-55-1 Zinc N,N-diethyldithiocarbamate CCN(CC)C(=S)S{-}.[Zn]{2+}.S{-}C(=S)N(CC)CC in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hedenstedt, A., U. Rannug, C. Ramel, C. A. Wachtmeister, Mutagenicity and Metabolism Studies on 12 Thiuram and Dithiocarbamate Compounds Used as Accelerators in the Swedish Rubber Industry, Mutat. Res. 68(4), (1979), 313 - 325. 137-26-8 Tetramethylthiuram disulfide (Thiram) CN(C)C(=S)SSC(=S)N(C)C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hedenstedt, A., U. Rannug, C. Ramel, C. A. Wachtmeister, Mutagenicity and Metabolism Studies on 12 Thiuram and Dithiocarbamate Compounds Used as Accelerators in the Swedish Rubber Industry, Mutat. Res. 68(4), (1979), 313 - 325. 137-29-1 Copper N,N-dimethyldithiocarbamate CN(C)C(=S)S{-}.[Cu]{2+}.S{-}C(=S)N(C)C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Donner, M., K. H. Pursianen, D. Jenssen, A. Rannug, Mutagenicity of Rubber Additives and Curing Fumes. Results from Five Short-Term Bioassays, Scand. J. Work Environ. Health 9, Suppl. 2 (1983), 27 - 37. 19010-66-3 Lead N,N-dimethyldithiocarbamate CN(C)C(=S)S{-}.[Pb]{2+}.S{-}C(=S)N(C)C in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Lead Dimethyldithiocarbamate, CASRN: 19010-66-3, Testing Status, National Toxicology Program, US Dept. of Health and Human Services; http://ntp.niehs.nih.gov/?objectid=BCDDD307-123F-7908-7BA298FF200E4D20 13889-92-4 S-(N-Propyl)Chlorothioformic acid CCCSC(=O)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 75-08-1 Ethyl mercaptan CCS in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb7508e0021/full 70-18-8 Glutathione NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Carter, M.H., P.D. Josephy , Biochem Pharmacol., 1986, 35(21):3847-51(-S9); Glatt, H., Mutagenicity spectra in Salmonella typhimurium strains of glutathione, L-cysteine and active oxygen species, Mutagenesis, 1989, 4(3), 221-227. 616-91-1 Acetylcysteine CC(=O)NC{P+}(CS)C(O)=O in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Glatt H., Endogenous mutagens derived from amino acids, Mutat Res., 1990, 238(3):235-43 2303-16-4 Diallate; Carbamic acid, diisopropylthio-, S-(2,3-dichloroallyl) ester CC(C)N(C(C)C)C(=O)SCC(Cl)=CCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SANDHU,SS, WATERS,MD, MORTELMANS,KE, EVANS,EL, JOTZ,MM, MITCHELL,AD AND KASICA, V; EVALUATION OF DIALLATE AND TRIALLATE HERBICIDES FOR GENOTOXIC EFFECTS IN A BATTERY OF IN VITRO AND SHORT-TERM IN VIVO TESTS; MUTAT. RES. 136(6):173-183, 1984 128-04-1 Sodium dimethyldithiocarbamate CN(C)C(=S)S{-}.[Na]{+} in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) MORIYA,M OHTA,T WATANABE,K MIYAZAWA,T KATO,K AND SHIRASU,Y; FURTHER MUTAGENICITY STUDIES ON PESTICIDES IN BACTERIAL REVERSION ASSAY SYSTEMS; MUTAT. RES. 116(3-4):185-216,1982 2303-17-5 Tri-allate CC(C)N(C(C)C)C(=O)SCC(Cl)=C(Cl)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) De Lorenzo, F., Staiano, N., Silengo, L., Cortese, R., Mutagenicity of Diallate, Sulfallate, and Triallate and Relationship Between Structure and Mutagenic Effects of Carbamates Used Widely in Agriculture. Cancer Res., 1978, 38(1), 13 - 15 156-57-0 cysteamine hydrochloride SCCN{+}.Cl{-} in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) D. Kirkland, L. Reeve, D. Gatehouse, P. Vanparys, A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins, Mutat. Res. 721 (2011) 27-73. 759-94-4 Eptam_(S-Ethyl-N,N-Dipropylthiocarbamate) CCCN(CCC)C(=O)SCC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 6088-51-3 6-Hydroxy-2-Naphthyl_Disulfide_(Ddd) Oc1ccc2cc(SSc3ccc4cc(O)ccc4c3)ccc2c1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 107-03-9 1-propanethiol CCCS in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Short-Term Testing Program in the National Cancer Institute (NCI), National Institutes of Health, US Department of Health and Human Services 65002-17-7 Bucillamine CC(C)(S)C(=O)NC{P+}(CS)C(O)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 80830-42-8 Rentiapril Oc1ccccc1C{P-}1N(C(=O)CCS)C{P+}(C(O)=O)CS1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 74586-09-7 Methylthio 2-(acetyloxy)propionate CC(C(=O)SC)OC(C)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) EFSA Journal 2011; 9(3):1842; Watanabe S and Morimoto Y, 1989a. Mutagenicity test (Salmonella, Escherichia coli/microsome). Acetyllactic acid thiomethyl ester. Central Research Laboratory. July 5, 1989. Unpublished report submitted by EFFA to SCF. 100-53-8 Benzyl mercaptan SCc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Hansen et al. J. Chem. Inf. Model., 2009, 49 (9), pp 2077-2081 156420-69-8 Allyl thiohexanoate CCCCCC(=O)SCC=C in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) EFSA Journal 2010;8(10):1337 54717-12-3 3,6-Diethyl-1,2,4,5-tetrathiane CCC1SSC(CC)SS1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) EFSA Journal 2010;8(10):1337 624-92-0 Dimethyl disulfide CSSC in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 108-98-5 Benzenethiol Sc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Hansen et al. J. Chem. Inf. Model., 2009, 49 (9), pp 2077-2081 882-33-7 Phenyl disulfide c1ccccc1SSc1ccccc1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 227456-33-9 3-Mercapto-2-methylbutan-1-ol CC(CO)C(C)S in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) Mattia A, WHO Food Additives Series:52 376595-42-5 O-Ethyl S-(2-furylmethyl)thiocarbonate CCOC(=O)SCC1=CC=CO1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) EFSA Journal; 9 (10):2315 111-88-6 1-Octanethiol CCCCCCCCS in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan