CAS Chem.name Chem.SMILES #Observed Mutagenicity without S9 #Observed Mutagenicity with S9 Bioassay - Reference(s) - 79-27-6 1,1,2,2-Tetrabromoethane BrC(Br)C(Br)Br in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Strubel, K., T. Grummt, Aliphatic and Aromatic Halocarbons as Potential Mutagens in Drinking Water. III. Halogenated Ethanes and Ethenes, Toxicol. Environ. Chem. 15(1-2) (1987), 101 – 128 78-87-5 1,2-Dichloro-Propane CC(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 106-93-4 1,2-Dibromoethane BrCCBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 616-23-9 2,3-Dichloro-1-Propanol OCC(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 78-88-6 2,3-Dichloro-1-Propene C=C(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) U.S.Environmental Protection Agency Gene-Tox Program. Mutation Research, 168, (1996) pp. 69-240 96-13-9 2,3-Dibromo-1-Propanol OCC(Br)CBr in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 760-23-6 3,4-Dichloro-1-butene C=CC(Cl)CCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 87619-82-7 s-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine NC(CSC(Cl)=C(Cl)C(Cl)=C(Cl)Cl)C(O)=O in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 79-00-5 1,1,2-Trichloroethane ClCC(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) STROBEL,K AND GRUMMT,T; ALIPHATIC AND AROMATIC HALOCARBONS AS POTENTIAL MUTAGENS IN DRINKING WATER. III. HALOGENATED ETHANES AND ETHENES; TOXICOL. ENVIRON. CHEM. 15(1-2):101-128, 1987; 630-20-6 1,1,1,2-Tetrachloroethane ClCC(Cl)(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) STROBEL,K AND GRUMMT,T; ALIPHATIC AND AROMATIC HALOCARBONS AS POTENTIAL MUTAGENS IN DRINKING WATER. III. HALOGENATED ETHANES AND ETHENES; TOXICOL. ENVIRON. CHEM. 15(1-2):101-128, 1987 96-12-8 1,2-Dibromo-3-chloropropane ClCC(Br)CBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Flora Ratpan and Heinz Plaumann; Mutagenicity of Halogenated Propanes and Their Methylated Derivatives; Environmental and Molecular Mutagenesis, 1988, 12, 253-259. 107-06-2 1,2-Dichloro-ethane ClCCCl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 79-01-6 Trichloroethylene ClC=C(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) STROBEL,K AND GRUMMT,T; ALIPHATIC AND AROMATIC HALOCARBONS AS POTENTIAL MUTAGENS IN DRINKING WATER. III. HALOGENATED ETHANES AND ETHENES; TOXICOL. ENVIRON. CHEM. 15(1-2):101-128, 1987 87-68-3 Hexachloro-1,3-butadiene ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Kazius J, McGuire R., Bursi R. Journal of Medicinal Chemistry 48 (1), pp. 312-32, 25 96-18-4 1,2,3-Trichloropropane ClCC(Cl)CCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 126-72-7 Tris(2,3-Dibromopropyl)Phosphate O=P(OCC(Br)CBr)(OCC(Br)CBr)OCC(Br)CBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 3066-70-4 2-Propenoic_acid,_2-methyl-,_2,3-dibromopropyl_ester CC(=C)C(=O)OCC(Br)CBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 13366-73-9 Photodieldrin ClC1C2(Cl)C3C4C5C(C3C3C4C1(Cl)C(Cl)(Cl)C23Cl)O5 in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 19660-16-3 2,3-Dibromopropyl crylate C=CC(=O)OCC(Br)CBr in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 127-18-4 Tetrachloroethylene ClC(Cl)=C(Cl)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) VAMVAKAS,S, et. al.; MUTAGENICITY OF TETRACHLOROETHENE IN THE AMES TEST-METABOLIC ACTIVATION BY CONJUGATION WITH GLUTATHIONE; J. BIOCHEM. TOXICOL. 4(1):21-27, 1989; SHIMADA,T, et. al.; ACTIVITIES OF CHLORINATED ETHANE AND ETHYLENE COMPOUNDS IN THE SALMONELLA/RAT MICROSOME MUTAGENESIS AND RAT HEPATOCYTE/DNA REPAIR ASSAYS UNDER VAPOR PHASE EXPOSURE CONDITIONS; CELL BIOL. TOXICOL. 1(3):159-179, 1985 58-89-9 Lindane ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 2425-06-1 Captafol O=C1C2CC=CCC2C(=O)N1SC(Cl)(Cl)C(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Barrueco, C. and De La Pena, E.; Mutagenic Evaluation of the Pesticides Captan, Folpet, Captafol, Dichlofluanid and Related Compounds with the Mutants TA 102 and TA 104 of Salmonella Typhimurium; Mutagenesis 3(6):467-480, 1988 12789-03-6 chlordane ClC1CC2C(C1Cl)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) ZEIGER,E, ANDERSON,B, HAWORTH,S, LAWLOR,T AND MORTELMANS,K; SALMONELLA MUTAGENICITY TESTS. V. RESULTS FROM THE TESTING OF 311 CHEMICALS; ENVIRON. MOL. MUTAGEN. 19(SUPPL.21):2-141, 1992 2303-16-4 Diallate; Carbamic acid, diisopropylthio-, S-(2,3-dichloroallyl) ester CC(C)N(C(C)C)C(=O)SCC(Cl)=CCl in vitro Ames negative in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) SANDHU,SS, WATERS,MD, MORTELMANS,KE, EVANS,EL, JOTZ,MM, MITCHELL,AD AND KASICA, V; EVALUATION OF DIALLATE AND TRIALLATE HERBICIDES FOR GENOTOXIC EFFECTS IN A BATTERY OF IN VITRO AND SHORT-TERM IN VIVO TESTS; MUTAT. RES. 136(6):173-183, 1984 8001-35-2 toxaphene CC1(C)C(=C)C2(Cl)C(Cl)(Cl)C1(Cl)C(Cl)(Cl)C2(Cl)Cl in vitro Ames positive in vitro Ames positive Bacterial Reverse Mutation Assay (e.g. Ames Test) Hosey, K. M. Quinn, J. J. Roche, M. Fogarty, C. A. Brougham, Screening for Genotoxicity and Oestrogenicity of Endocrine Disrupting Chemicals In Vitro, J. Environ. Protection 3 (21012), 902 – 914 60-57-1 Dieldrin ClC1=C(Cl)C2(Cl)C3C4CC(C3C1(Cl)C2(Cl)Cl)C1C4O1 in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 76-44-8 Heptachlor ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 115-29-7 Endosulfan O=S1OCC2C(CO1)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 309-00-2 Aldrin ClC1=C(Cl)C2(Cl)C3C4CC(C=C4)C3C1(Cl)C2(Cl)Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory 87-84-3 1,2,3,4,5-Pentabromo-6-Chlorocyclohexane ClC1C(Br)C(Br)C(Br)C(Br)C1Br in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 526-78-3 2,3-Dibromosuccinic Acid OC(=O)C(Br)C(Br)C(O)=O in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) NIHS Japan 156-59-2 Cis-1,2-Dichloroethylene Cl/C=C\Cl in vitro Ames negative in vitro Ames negative Bacterial Reverse Mutation Assay (e.g. Ames Test) National Toxicology program. P&G Inventory