CAS Chem.name Chem.SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 95-64-7 3,4-Xylidine Cc1ccc(N)cc1C negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 108-44-1 3-Aminotoluene Cc1cccc(N)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 611-06-3 2,4-Dichloronitrobenzene [O-][N+](=O)c1ccc(Cl)cc1Cl negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-88-7 4-isopropylaniline;_p-Isopropylaniline CC(C)c1ccc(N)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 55-80-1 3-Methyl-4'-(dimethylamino)azobenzene Cc1cccc(N=Nc2ccc(N(C)C)cc2)c1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-59-2 2,3-Xylidine Cc1cccc(N)c1C negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-51-2 o-Chloroaniline Nc1ccccc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 106-47-8 p-Chloroaniline Nc1ccc(Cl)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-69-0 3,5-Xylidine Cc1cc(C)cc(N)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 134-32-7 1-Naphthylamine Nc1cccc2ccccc12 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 554-00-7 2,4-Dichloroaniline Nc1ccc(Cl)cc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 91-23-6 o-nitroanizole COc1ccccc1[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 100-17-4 4-nitroanisole COc1ccc(cc1)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 89-61-2 1,4-Dichloro-2-nitrobenzene [O-][N+](=O)c1cc(Cl)ccc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 90-04-0 o-Anisidine COc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-05-0 N,N-Diethyl-p-Phenylenediamine CCN(CC)c1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 95-54-5 o-Phenylenediamine Nc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-98-9 N,N-Dimethyl-p-Phenylenediamine CN(C)c1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 101-14-4 4,4'-Methylenebis(2-Chloroaniline) Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 103-69-5 N-Ethylaniline CCNc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 104-94-9 p-Anisidine COc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-45-2 m-Phenylenediamine Nc1cccc(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 156-43-4 p-Phenetidine CCOc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 536-90-3 m-Anisidine COc1cccc(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 3209-22-1 2,3-Dichloronitrobenzene [O-][N+](=O)c1cccc(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 15481-70-6 Toluene-2,6-diamine, dihydrochloride Cc1c(N)cccc1N_Cl_Cl positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 823-40-5 2,6-diaminotoluene Cc1c(N)cccc1N positive positive in Vitro Mammalian Chromosome Aberration Test ARMSTRONG,MJ, BEAN,CL AND GALLOWAY,SM; A QUANTITATIVE ASSESSMENT OF THE CYTOTOXICITY ASSOCIATED WITH CHROMOSOMAL ABERRATION DETECTION IN CHINESE HAMSTER OVARY CELLS; MUTAT. RES. 265(1):45-60, 1992 42397-64-8 1,6-Dinitropyrene [O-][N+](=O)c1ccc2ccc3c(ccc4ccc1c2c34)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-62-7 2,6-Xylidine Cc1cccc(C)c1N positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-53-4 2-methylbenzenamine Cc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 67730-11-4 2-amino-6-methyldipyrido(1,2-a:3',2'-d)imidazole; GLU-P-1 CC1=CC=CN2C1=Nc1ccc(N)nc21 positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 106-49-0 4-Aminotoluene; p-toluidine Cc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 26148-68-5 2-amino-9h-pyrido[2,3-b]indole; a-alpha-c; 2-amino-9h-pyrido(2,3-b)indole Nc1ccc2c(Nc3ccccc-23)n1 positive positive in Vitro Mammalian Chromosome Aberration Test IARC Monographs on the evaluation of the carcinogenic risk of chemicals to human, v. 40, 1986, pp. 245-252 100-00-5 1-Chloro-4-nitrobenzene [O-][N+](=O)c1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 5131-60-2 4-Chloro-m-phenylenediamine Nc1ccc(Cl)c(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996; Loveday, Ks., Anderson, Be., Resnick, Ma., Zeiger, E.; Chromosome Aberration And Sister Chromatid Exchange Tests In Chinese Hamster Ovary Cells In Vitro, V: Results With 46 Chemicals; Environ. 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Mutagen. 16(9):272-303, 1990 95-83-0 4-chloro-o-phenylenediamine Nc1ccc(Cl)cc1N positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; 95-80-7 Toluene-2,4-diamine Cc1ccc(N)cc1N positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; 95-70-5 2,5-diaminotoluene Cc1cc(N)ccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Products OPINION ON Toluene-2,5-diamine COLIPA n A5 The SCCP adopted this opinion at its 13th plenary meeting on 2 October 2007 99-54-7 3,4-dichloronitrobenzene [O-][N+](=O)c1ccc(Cl)c(Cl)c1 positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005 609-20-1 2,6-dichloro-p-phenylenediamine Nc1cc(Cl)c(N)c(Cl)c1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 119-93-7 Orthotolidine Cc1cc(-c2ccc(N)c(C)c2)ccc1N positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 101-80-4 4,4'-oxydianiline Nc1ccc(Oc2ccc(N)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 137-17-7 2,4,5-trimethylaniline; trimethylaniline, 2,4,5-; 2,4,5trimethylaniline[1] Cc1cc(C)c(C)cc1N positive positive in Vitro Mammalian Chromosome Aberration Test LOVEDAY,KS ANDERSON,BE RESNICK,MA ZEIGER,E; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO, V: RESULTS WITH 46 CHEMICALS; ENVIRON. MOL. MUTAGEN. 16(9):272-303, 1990 13552-44-8 Methylenedianiline dihydrochloride Cl_Cl_Nc1ccc(Cc2ccc(N)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(N=Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate, M. Jr, Harnois, M.C., Sofuni, T., A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 1988, 195(2), 151-213. 39156-41-7 2,4-Diaminoanisole Sulfate COc1ccc(N)cc1N_OS(O)(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan