CAS Chem.name Chem.SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 58-25-3 3H-1,4-Benzodiazepin-2-amine,_7-chloro-N-methyl-5-phenyl-,_4-oxide CNC1C[N+](=C(c2ccccc2)c2cc(Cl)ccc2N=1)[O-] negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 134-62-3 N,N-Diethyl-M-Toluamide (Deet) CCN(CC)C(=O)c1cccc(C)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 439-14-5 Diazepam CN1C(=O)CN=C(c2ccccc2)c2cc(Cl)ccc12 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 6505-28-8 2,2'-((3,3'-Dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(3-oxo-N-phenylbutyramide) CC(=O)C(C(=O)Nc1ccccc1)N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccccc3)c(OC)c2)cc1OC negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 6448-95-9 Pigment red 22 Cc1ccc(cc1N=Nc1c(O)c(cc2ccccc12)C(=O)Nc1ccccc1)[N+](=O)[O-] negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 50-37-3 Lysergide CCN(CC)C(=O)C{P-}1CN(C)C{P+}2CC3=CNc4cccc(C2=C1)c34 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 129-51-1 Ergometrine maleate CC(CO)NC(=O)C1CN(C)C2CC3=CNc4cccc(C2=C1)c34 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 26630-87-5 Disperse Red 206 CC(=O)OCCN(CCOC(C)=O)c1ccc(N=NC2=Nc3ccc(Cl)cc3S2)c(NC(=O)c2ccccc2)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1918-16-7 propachlor CC(C)N(C(=O)CCl)c1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test UNITED STATES ENVIRONMENTAL PROTECTION AGENCY, Prevention, Pesticides And Toxic Substances (7508C), EPA 738-R-015, November 1998 2832-40-8 c.i. disperse yellow 3 CC1=CC(=NNc2ccc(NC(C)=O)cc2)C(=O)C=C1 negative negative in Vitro Mammalian Chromosome Aberration Test Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ. Mol. Mutagen., 1989,14(3),165-187. 6471-49-4 c.i. pigment red 23 COc1ccc(cc1NN=C1C(=O)C(=Cc2ccccc12)C(=O)Nc1cccc(c1)[N+](=O)[O-])[N+](=O)[O-] negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CAS No. 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1992, 411, 1-283. 2512-29-0 butanamide, 2- (4-methyl-2-nitrophenyl)azo -3-oxo-n-phenyl-; hansa yellow; c.i. pigment yellow 1 CC(=O)C(N=Nc1ccc(C)cc1[N+](=O)[O-])C(=O)Nc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test 2-[(4-Methyl-2-nitrophenyl)azo]-3-oxo-N-phenylbutyramide, CAS No 2512-29-0. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/13177/1 2786-76-7 2-naphthalenecarboxamide, 4-[[4-(aminocarbonyl)phenyl]azo]-n-(2-ethoxyphenyl)-3-hydroxy- CCOc1ccccc1NC(=O)c1cc2ccccc2c(N=Nc2ccc(C(N)=O)cc2)c1O negative negative in Vitro Mammalian Chromosome Aberration Test 4-[[4-(Aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide, CAS No 2786-76-7. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/14874 5280-68-2 2-naphthalenecarboxamide, n-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]- COc1ccc(C(=O)Nc2ccccc2)cc1N=Nc1c2ccccc2cc(C(=O)Nc2cc(OC)c(Cl)cc2OC)c1O negative negative in Vitro Mammalian Chromosome Aberration Test N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]naphthalene-2-carboxamide, CAS No 5280-68-2. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/14808 68134-22-5 butanamide, n-(2,3-dihydro-2-oxo-1h-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluoromethyl)phenyl]azo]- CC(=O)C(C(=O)Nc1ccc2c(c1)NC(=O)N2)N=Nc1ccccc1C(F)(F)F negative negative in Vitro Mammalian Chromosome Aberration Test N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluoromethyl)phenyl]azo]butyramide, CAS No 68134-22-5. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/14436 68227-78-1 2-naphthalenecarboxamide, n-(5-chloro-2-methylphenyl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]- Cc1ccc(Cl)cc1NC(=O)c1cc2ccccc2c(N=Nc2cc(C(=O)Nc3ccccc3)ccc2OC)c1O negative negative in Vitro Mammalian Chromosome Aberration Test N-(5-Chloro-2-methylphenyl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]naphthalene-2-carboxamide, CAS No 68227-78-1. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/11197 82199-12-0 n-(2,3-dihydro-2-oxo-1h-benzimidazol-5-yl)-2-[(2-methoxyphenyl)azo]-3-oxobutyramide CC(=O)C(C(=O)Nc1ccc2c(c1)NC(=O)N2)N=Nc1ccccc1OC negative negative in Vitro Mammalian Chromosome Aberration Test N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-2-[(2-methoxyphenyl)azo]-3-oxobutyramide, CAS No 82199-12-0. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/5446 6358-85-6 pigment yellow-12 CC(=O)C(C(=O)Nc1ccccc1)N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccccc3)c(Cl)c2)cc1Cl negative negative in Vitro Mammalian Chromosome Aberration Test Morita, T., Hamada, S., Masumura, K., Wakata, A., Maniwa, J., Takasawa, H., Yasunaga, K., Hashizume, T., Honma, M., Evaluation of the sensitivity and specificity of in vivo erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogens. Mutat. Res., 2016, 802, 1-29. 53-96-3 2-acetylaminofluorene CC(=O)Nc1ccc2c(Cc3ccccc-23)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Matsuoka, A., M. Hayashi and M. Ishidate Jr. (1979), Mutation Res., 66, 277-290 65-45-2 Salicylamide NC(=O)c1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-68-5 butanamide,_n-(2-methylphenyl)-3-oxo- CC(=O)CC(=O)Nc1ccccc1C positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 103-90-2 Acetaminophen CC(=O)Nc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 536-33-4 Ethionamide CCc1cc(C(N)=S)ccn1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 938-73-8 ethenzamide; Benzamide, 2-ethoxy- CCOc1ccccc1C(N)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 15972-60-8 Alachlor CCc1cccc(CC)c1N(COC)C(=O)CCl positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 98-92-0 Niacinamide NC(=O)c1cccnc1 positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 23184-66-9 Butachlor CCCCOCN(C(=O)CCl)c1c(CC)cccc1CC positive positive in Vitro Mammalian Chromosome Aberration Test Lin MF, Wu CL, Wang TC, Pesticide clastogenicity in CHO cells, Mutat. Res., 1987 Jul; 188(3):241-50 2380-86-1 6-Hydroxyindole Oc1ccc2C=CNc2c1 positive positive in Vitro Mammalian Chromosome Aberration Test SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS Opinion on 6-Hydroxyindole COLIPA N A128 Adopted by the SCCP during the 7th plenary meeting of 28 March 2006 SCCP/0947/05