CAS	Chem.name	Chem.SMILES	#CA_without_S9	#Obs_CA_with_S9	Bioassay - 	Reference(s) -
11070-44-3	Tetrahydromethylphthalic anhydride	CC1C=CCC2C1C(=O)OC2=O	negative	negative	in Vitro Mammalian Chromosome Aberration Test 	NIHS Japan
34090-76-1	Methyltetrahydrophthalic anhydride (MTHPA)	CC1CCC2=C(C1)C(=O)OC2=O	negative	negative	in Vitro Mammalian Chromosome Aberration Test 	U.S. Environmental Protection Agency, September, 2009 Hazard Characterization Document, SCREENING-LEVEL HAZARD CHARACTERIZATION Cyclic Anhydrides Category
117-08-8	Tetrachlorophthalic anhydride	O=C1c2c(Cl)c(Cl)c(Cl)c(Cl)c2C(=O)O1	negative	negative	in Vitro Mammalian Chromosome Aberration Test 	Galloway S., et al., Environ. Mol. Mutagenesis, 10, 1-175, 1987.
118-45-6	4-Chlorophthalic anhydride	O=C1c2ccc(Cl)cc2C(=O)O1	negative	negative	in Vitro Mammalian Chromosome Aberration Test 	4-Chlorophthalic Anhydride, OECD, Guideline 473, In vitro Mammalian Chromosome Aberration Test, ECHA-Europe, June 2003.
552-30-7	Trimellitic anhydride	OC(=O)c1ccc2c(c1)C(=O)OC2=O	negative	negative	in Vitro Mammalian Chromosome Aberration Test 	Trimellitic Anhydride and Trimellitic Acid, SIDS Initial Assessment Report for 15th SIAM, Boston, 2002.( Bigger, C.A. and Sigler, C.I. 1991. CHO/HGPRT mutation assay with confirmation. Final Report.Microbiological Associates, Inc. Laboratory Study Number TA039.332001; Putnam, D.L. and Morris, M.J. 1991. Chromosome aberrations in chinese hamster ovary (CHO) cells.Final Report. Microbiological Associates, Inc. Laboratory Study Number TA039.337100).
108-31-6	Maleic Anhydride	O=C1C=CC(=O)O1	positive	positive	in Vitro Mammalian Chromosome Aberration Test 	Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan
1466-82-6	Aspirin_anhydride	CC(=O)Oc1ccccc1C(=O)OC(=O)c1ccccc1OC(C)=O	positive	positive	in Vitro Mammalian Chromosome Aberration Test 	Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan.
85-44-9	Phthalic anhydride	O=C1c2ccccc2C(=O)O1	positive	positive	in Vitro Mammalian Chromosome Aberration Test 	HILLIARD,CA ARMSTRONG,MJ BRADT,CI HILL,RB GREENWOOD,SK AND GALLOWAY,SM; CHROMOSOME ABERRATIONS IN VITRO RELATED TO CYTOTOXICITY OF NONMUTAGENIC CHEMICALS AND METABOLIC POISONS; ENVIRON. MOL. MUTAGEN. 31(4):316-326, 1998