CAS Chem.name Chem.SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 72-43-5 Methoxychlor COc1ccc(C(c2ccc(OC)cc2)C(Cl)(Cl)Cl)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 80-43-3 Cumene peroxide CC(C)(c1ccccc1)OOC(C)(C)c1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 87-61-6 1,2,3-Trichlorobenzene Clc1cccc(Cl)c1Cl negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 96-69-5 4,4'-thiobis(6-tert-butyl-m-cresol) Cc1cc(O)c(C(C)(C)C)cc1Sc1cc(C(C)(C)C)c(O)cc1C negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 100-41-4 Ethyl Benzene CCc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 106-46-7 1,4-Dichlorobenzene Clc1ccc(Cl)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 118-74-1 Hexachlorobenzene Clc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 119-47-1 p-Cresol, 2,2'-methylenebis(6-tert- butyl- Cc1cc(Cc2cc(C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 140-66-9 4-(1,1,3,3-Tetramethylbutyl)phenol CC(C)(C)CC(C)(C)c1ccc(O)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 439-14-5 Diazepam CN1C(=O)CN=C(c2ccccc2)c2cc(Cl)ccc12 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 11042-64-1 gamma-Oryzanol CC(CCC=C(C)C)C1CCC2(C)C3CCC4C(C)(C)C(OC(=O)C=Cc5ccc(O)c(OC)c5)CCC44CC34CCC12C negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1843-05-6 Octabenzone; (2-Hydroxy-4-(octyloxy)phenyl)phenylmethanone CCCCCCCCOc1ccc(C(=O)c2ccccc2)c(O)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 25154-52-3 Nonylphenol CCCCCCCCCc1ccc(O)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 5707-44-8 1,1'-Biphenyl, 4-ethyl- CCc1ccc(-c2ccccc2)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 6165-51-1 Benzene, 1,4-dimethyl-2-(1-phenylethyl)- CC(c1ccccc1)c1cc(C)ccc1C negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 76-83-5 Chlorotriphenylmethane ClC(c1ccccc1)(c1ccccc1)c1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 83-32-9 Acenaphthene C1Cc2cccc3cccc1c23 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 87-86-5 Pentachlorophenol, Technical Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 89-83-8 5-methyl-2-(1-methylethyl)phenol; Thymol CC(C)c1ccc(C)cc1O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 92-52-4 Biphenyl c1ccccc1-c1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 94-59-7 Safrole C=CCc1ccc2c(c1)OCO2 negative positive in Vitro Mammalian Chromosome Aberration Test Ishidate Jr., M., and T. Sofuni (1985) in: J. Ashby et al.(Eds.), Progress in Mutation Research, Vol. 5, Elsevier, 97-52-9 benzenamine, 2-methoxy-4-nitro- COc1cc(ccc1N)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 120-12-7 Anthracene c1cccc2cc3ccccc3cc12 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 935-95-5 2,3,5,6-Tetrachlorophenol Oc1c(Cl)c(Cl)cc(Cl)c1Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1570-64-5 4-Chloro-2-methyl-phenol Cc1cc(Cl)ccc1O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 2216-69-5 1-Methoxynaphthalene COc1cccc2ccccc12 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 88-60-8 phenol,_2-(1,1-dimethylethyl)-5-methyl- Cc1ccc(C(C)(C)C)c(O)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 611-19-8 benzene, 1-chloro-2-(chloromethyl)- ClCc1ccccc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 88-18-6 2-(1,1-dimethylethyl)phenol CC(C)(C)c1ccccc1O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 96-76-4 2,4-Di-tert-butylphenol CC(C)(C)c1ccc(O)c(C(C)(C)C)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 106-37-6 p-Dibromobenzene Brc1ccc(Br)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 26630-87-5 Disperse Red 206 CC(=O)OCCN(CCOC(C)=O)c1ccc(N=NC2=Nc3ccc(Cl)cc3S2)c(NC(=O)c2ccccc2)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 4901-51-3 2,3,4,5-Tetrachlorophenol Oc1cc(Cl)c(Cl)c(Cl)c1Cl negative positive in Vitro Mammalian Chromosome Aberration Test SOFUNI,T, MATSUOKA,A, SAWADA,M, ISHIDATE,MJR, ZEIGER,E AND SHELBY,MD; A COMPARISON OF CHROMOSOME ABERRATION INDUCTION BY 25 COMPOUNDS TESTED BY TWO CHINESE HAMSTER CELL (CHL AND CHO) SYSTEMS IN CULTURE; MUTAT. RES. 241(2):175-213, 1990 90-41-5 2-aminobiphenyl (2-phenylaniline) Nc1ccccc1-c1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test http://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF90-41-5f.pdf 394-69-4 5-fluoroquinoline Fc1cccc2c1cccn2 negative positive in Vitro Mammalian Chromosome Aberration Test Suzuki, T., Takeshita, K., Saeki, K., Kadoi, M., Hayashi, M. and Sofuni, T.; Clastogenicity of Quinoline and Monofluorinated Quinolines in Chinese Hamster Lung Cells; J. Health Sci. 53(3):325-328, 2007 148-24-3 oxyquinoline [usan]; 8-quinolinol; Oc1cccc2cccnc12 negative positive in Vitro Mammalian Chromosome Aberration Test Loveday et al. (1990) 91-23-6 o-nitroanizole COc1ccccc1[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 91-20-3 Naphthalene c1cccc2ccccc12 negative positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 4; 2008 16071-86-6 c.i. direct brown 95 O=C1C=CC(=NNc2cc3ccc2O{-}.[Cu]{2+}.O{-}S3(=O)=O)C(=O)C1=NNc1ccc(-c2ccc(N=Nc3ccc(O{-}.[Na]{+})c(C(=O)O{-}.[Na]{+})c3)cc2)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175. 26021-57-8 hydroxybenzomorpholine; 3,4-dihydro-2h-1,4-benzoxazin-6-ol Oc1ccc2c(c1)NCCO2 negative negative in Vitro Mammalian Chromosome Aberration Test SCCP (Scientific Committee on Consumer Products), Opinion on Hydroxybenzomorpholine, 20 June 2006. 1825-21-4 pentachloroanisole COc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of Pentachloroanisole (CAS No. 1825-21-4) in F344 Rats and B6C3F1 Mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1993, 414, 1-284. 51630-58-1 Fenvalerate CC(C)C(c1ccc(Cl)cc1)C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Caballo C., Herrara A., Barrueco C., Santa-Maria A., Sanz F., De La Plena E., Analysis Of Cytogenetic Damage Induced In CHO Cells By The Pyrethroid Insecticide Fenvalerate, Terato. Carcino. Mutagen., 1992, 12(6), 243-249 2786-76-7 2-naphthalenecarboxamide, 4-[[4-(aminocarbonyl)phenyl]azo]-n-(2-ethoxyphenyl)-3-hydroxy- CCOc1ccccc1NC(=O)c1cc2ccccc2c(N=Nc2ccc(C(N)=O)cc2)c1O negative negative in Vitro Mammalian Chromosome Aberration Test 4-[[4-(Aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide, CAS No 2786-76-7. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/14874 103597-45-1 2,2'-methylenebis(6-(2h-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) CC(C)(C)CC(C)(C)c1cc(Cc2cc(C(C)(C)CC(C)(C)C)cc(N3N=C4C=CC=CC4=N3)c2O)c(O)c(N2N=C3C=CC=CC3=N2)c1 negative negative in Vitro Mammalian Chromosome Aberration Test [1] 2,2'-Methylene bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol). ECHA Legal notice, Registration dossier. https://echa.europa.eu/registration-dossier/-/registered-dossier/5321 59-98-3 Tolazoline C1CNC(Cc2ccccc2)=N1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 61-25-6 Papaverine Hydrochloride COc1ccc(Cc2c3cc(OC)c(OC)cc3ccn2)cc1OC positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 63-25-2 carbaryl CNC(=O)Oc1cccc2ccccc12 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 65-45-2 Salicylamide NC(=O)c1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 68-89-3 Dipyrone CC1=C(N(C)CS(O)(=O)=O)C(=O)N(c2ccccc2)N1C positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 92-88-6 [1,1'-biphenyl]-4,4'-diol Oc1ccc(-c2ccc(O)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-57-8 o-Chlorophenol Oc1ccccc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 97-53-0 1-Allyl-3-Methoxy-4-Hydroxybenzene COc1cc(CC=C)ccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-76-3 Methyl-p-hydroxybenzoate COC(=O)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 104-55-2 cinnamaldehyde;_2-Propenal,_3-phenyl- O=CC=Cc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-39-4 m-Cresol Cc1cccc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 108-73-6 Phloroglucinol; 1,3,5-Benzenetriol Oc1cc(O)cc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 118-79-6 2,4,6-Tribromophenol Oc1c(Br)cc(Br)cc1Br positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 120-47-8 Ethyl-p-hydroxybenzoate CCOC(=O)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 121-79-9 Propyl Gallate CCCOC(=O)c1cc(O)c(O)c(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 121-88-0 2-Amino-5-Nitrophenol Nc1ccc(cc1O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 149-91-7 Gallic Acid Oc1cc(C(O)=O)cc(O)c1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 154-23-4 Catechin OC1Cc2c(cc(O)cc2O)OC1c1ccc(O)c(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 396-01-0 Triamterene Nc1c2c(nc(N)c(-c3ccccc3)n2)nc(N)n1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 458-37-7 Curcumin COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 477-30-5 Colcemid CNC1CCc2cc(OC)c(OC)c(OC)c2C2=CC=C(OC)C(=O)C=C12 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 637-07-0 Clofibrate CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 882-09-7 Colfibric_acid CC(C)(C(O)=O)Oc1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 938-73-8 ethenzamide;_Benzamide,_2-ethoxy-;_Benzamide,_o-ethoxy- CCOc1ccccc1C(N)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1129-41-5 3-Methylphenyl_N-methylcarbamate Cc1cccc(OC(=O)NC)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1401-55-4 Tannic_acid OC1C(COC(=O)c2cc(O)c(O)c(O)c2)OC(OC(=O)c2cc(O)c(O)c(O)c2)C(O)C1OC(=O)c1cc(O)c(O)c(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 2425-10-7 Phenol, 3,4-dimethyl-, methylcarbamate; Xylylcarb Cc1ccc(OC(=O)NC)cc1C positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 7090-25-7 Nitrosocarbaryl CN(C(=O)Oc1cccc2ccccc12)N=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 58139-33-6 3,4-Dimethylphenyl-N-nitroso-N-methylcarbamate Cc1ccc(OC(=O)N(C)N=O)cc1C positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 58139-35-8 3-Methylphenyl_N-nitroso_N-methylcarbamate Cc1cccc(OC(=O)N(C)N=O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate Jr., M., and S. Odashima (1977) Mutation Res.,48, 337-354. 60687-93-6 Lacchaic acid CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(O)=O)c2C(O)=O)C3=O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 2581-34-2 4-Nitro-3-cresol Cc1cc(O)ccc1[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 91-76-9 1,3,5-triazine-2,4-diamine,_6-phenyl- Nc1nc(-c2ccccc2)nc(N)n1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 2416-94-6 2,3,6-trimethylphenol Cc1ccc(C)c(C)c1O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 123-07-9 Phenol, 4-ethyl- CCc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1333-16-0 Bisphenol F (mixed isomers) Oc1ccccc1Cc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 620-92-8 4,4'-Methylenebis(phenol) Oc1ccc(Cc2ccc(O)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 824-78-2 p-Nitrophenol sodium salt [Na+].[O-]c1ccc(cc1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 2257-09-2 Phenethyl isothiocyanate S=C=NCCc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Musk S., T. Smith, et al., Mutation Research, 348, 19-23, (1995) 88-06-2 2,4,6-Trichlorophenol Oc1c(Cl)cc(Cl)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test WORLD HEALTH ORGANIZATION, INTERNATIONAL AGENCY FOR RESEARCH ON CANCER - IARC, MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide VOLUME 71, p.796-816 95-95-4 2,4,5-Trichlorophenol Oc1cc(Cl)c(Cl)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test Armstrong MJ, et. al., 2,4,6-Trichlorophenol (TCP) induces chromosome breakage and aneuploidy in vitro, Mutat Res,303(3),1993,101-108 98-54-4 p-tert-Butylphenol; Phenol, 4-(1,1-dimethylethyl)- CC(C)(C)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test p-tert-Butylphenol, CAS No 98-54-4,OECD SIDS Initial Assessment Report for 10th SIAM, Japan, march 15-17,2000 620-17-7 Phenol, 3-ethyl- CCc1cccc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test SCREENING-LEVEL HAZARD CHARACTERIZATION OF HIGH PRODUCTION VOLUME CHEMICALS, March, 2008, INTERIM 80-05-7 4,4'-Isopropylidenediphenol CC(C)(c1ccc(O)cc1)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tayama S., Nakagava Y., Tayama K., Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells, Mutat. Research649 (2008), 114-125Issues 1-2 89-72-5 O-sec-Butylphenol CCC(C)c1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test M.Matsumoto, et.al, Bull.Natl.Inst. health Sci., 2011,129, 68-75 106-48-9 p-Chlorophenol Oc1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS 120-83-2 2,4-Dichlorophenol Oc1ccc(Cl)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test HILLIARD,CA et al ; ENVIRON. MOL. MUTAGEN. 31(4):316-326, 1998 599-64-4 phenol,_4-(1-methyl-1-phenylethyl)- CC(C)(c1ccccc1)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Miller, J.E., Armstrong, M.J., Bean, C.L., Skopek, T.R., Nichols, W.W., DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens. Mutat. Res., 1998, 400(1-2), 169-186. 99-71-8 Phenol,_4-(1-methylpropyl)- CCC(C)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Kusakabe, H., Yamakage, K., Wakuri, S., Sasaki, K., Nakagawa, Y., Watanabe, M., Hayashi, M., Sofuni, T., Ono, H., Tanaka, N., Relevance of chemical structure and cytotoxicity to the induction of chromosome aberrations based on the testing results of 98 high production volume industrial chemicals. Mutat. Res., 2002, 517(1-2), 187-198. 59-92-7 Levodopa NC(Cc1ccc(O)c(O)c1)C(O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 90-43-7 1,1'-biphenyl-2-ol Oc1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tayama-Nawai, S., Yoshida, S., Nakao, T., Hiraga, K., Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol. Mutat. Res., 1984, 141(2), 95-99. 94-26-8 N-Butyl-p-hydroxybenzoate CCCCOC(=O)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tayama S., Nakagava Y., Tayama K., Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells, Mutat. Research649 (2008), 114-125Issues 1-2 117-39-5 Quercetin Oc1ccc(C2=C(O)C(=O)c3c(cc(O)cc3O)O2)cc1O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 132-27-4 O-Phenylphenate Sodium [Na]{+}.O{-}c1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test ortho-PHENYLPHENOL AND ITS SODIUM SALT, IARC MONOGRAPHS VOLUME 73, p.451-480; Tayama, S. & Nakagawa, Y., Mutat. Res., 1991, 259, 1–12 550-10-7 Hydrocotarnine_hydrochloride CN1CCc2cc3c(c(OC)c2C1)OCO3 positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 555-30-6 2-methyl-3-(3,4-dihydroxyphenyl)-L-alanine CC{P+}(N)(Cc1ccc(O)c(O)c1)C(O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 933-75-5 2,3,6-trichlorophenol Oc1c(Cl)ccc(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test SOFUNI,T, et al; A COMPARISON OF CHROMOSOME ABERRATION INDUCTION BY 25 COMPOUNDS TESTED BY TWO CHINESE HAMSTER CELL (CHL AND CHO) SYSTEMS IN CULTURE; MUTAT. RES. 241(2), 1990, 175-213 933-78-8 2,3,5-trichlorophenol Oc1cc(Cl)cc(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 1079-21-6 2,5-Dihydroxybiphenyl Oc1ccc(O)cc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test S.Tayama et al., Mutat.Res., 1989, 223(1), 23-33 15950-66-0 2,3,4-trichlorophenol Oc1ccc(Cl)c(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Sofuni, T., Shelby, M.D., Thilagar, A., Kumaroo, V., Kaur, P., Gulati, D., Putman, D.L., Murli, H., Marshall, R., Tanaka, N., Anderson, B., Zeiger, E., Ishidate, M. Jr, Multilaboratory comparison of in vitro tests for chromosome aberrations in CHO and CHL cells tested under the same protocols. Environ. Mol. Mutagen., 1997, 29(2), 189-207. 58-90-2 2,3,4,6-Tetrachlorophenol Oc1c(Cl)cc(Cl)c(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test WORLD HEALTH ORGANIZATION, INTERNATIONAL AGENCY FOR RESEARCH ON CANCER - IARC, MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide VOLUME 71, p.796-816 94-13-3 Propylparaben CCCOC(=O)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tayama S., Nakagava Y., Tayama K., Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells, Mutat. Research649 (2008), 114-125Issues 1-2 38777-13-8 N-Nitrosopropoxur CC(C)Oc1ccccc1OC(=O)N(C)N=O positive positive in Vitro Mammalian Chromosome Aberration Test LIN,C, WEI,LY, AND WANG,T; FOOD AND CHEMICAL TOXICOLOGY 45(6):928-934, 2007 3380-34-5 Triclosan Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl negative negative in Vitro Mammalian Chromosome Aberration Test Rodricks, J.V., Swenberg, J.A., Borzelleca, J.F., Maronpot, R.R., Shipp, A.M., Triclosan: a critical review of the experimental data and development of margins of safety for consumer products. Crit. Rev. Toxicol., 2010, 40(5), 422-484. 95-85-2 2-Amino-4-chlorophenol Nc1cc(Cl)ccc1O positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 4; 2008 100-44-7 Benzyl chloride ClCc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL), 1997 33419-42-0 Etoposide CC1OCC2C(C(O)C(O)C(OC3C4COC(=O)C4C(c4cc(OC)c(O)c(OC)c4)c4cc5c(cc34)OCO5)O2)O1 positive positive in Vitro Mammalian Chromosome Aberration Test GUIMARAES,APA DIAS,FL CARDOSO,RS KRONKA,SN AND SAKAMOTO-HOJO,ET; CHROMOSOMAL ABERRATIONS INDUCED BY 5-AZACYTIDINE COMBINED WITH VP-16 (ETOPOSIDE) IN CHO-K1 AND XRS-5 CELL LINES; TERATOG. CARCINOG. MUTAGEN. 23(SUPPL. 1):171-186, 2003 518-28-5 podophyllotoxin COc1cc(C2C3C(COC3=O)C(O)c3cc4c(cc23)OCO4)cc(OC)c1OC positive positive in Vitro Mammalian Chromosome Aberration Test Mei Chih Lin, Hui Wen Cheng, Yi Chen Tsai, Po Lin Liao, Jaw Jou Kang, and Yu Wen Cheng; Podophyllin, but not the constituents quercetin or kaempferol, induced genotoxicity in vitro and in vivo through ROS production; Drug Chem Toxicol, January 2009, Vol. 32, No. 1 , Pages 68-76 87-66-1 pyrogallol (1,2,3-trihydroxybenzene) Oc1cccc(O)c1O positive positive in Vitro Mammalian Chromosome Aberration Test SILVA,MDC GASPAR,J SILVA,ID LEAO,D AND RUEFF,J INDUCTION OF CHROMOSOMAL ABERRATIONS BY PHENOLIC COMPOUNDS: POSSIBLE ROLE OF REACTIVE OXYGEN SPECIES; MUTAT. RES. 540(1):29-42, 2003 6151-30-0 quinacrine dihydrochloride dihydrate CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12_Cl_Cl_O_O positive positive in Vitro Mammalian Chromosome Aberration Test J.A. Clarke, D.C. Sokal, A.M. Cancel, D.B. Campen, R. Gudi, V.O. Wagner, R.H.C. San, D. Jacobson-Kram, Re-evaluation of the mutagenic potential of quinacrine dihydrochloride hydrate, Mutat. Res. 494 (2001) 41-53. 23214-92-8 doxorubicin; adriamycin CC1C(O)C(N)CC(OC2CC(O)(C(=O)CO)Cc3c2c(O)c2c(c3O)C(=O)c3cccc(OC)c3C2=O)O1 positive positive in Vitro Mammalian Chromosome Aberration Test Dr. William W. Au, Dennis A. Johnston, Cheryl Collie-Bruyere andT. C. Hsu; Short-term cytogenetic assays of nine cancer chemotherapeutic drugs with metabolic activation, Environmental Mutagenesis Volume 2, Issue 4, pages 455–464, 1980 114-26-1 Propoxur CC(C)Oc1ccccc1OC(=O)NC positive positive in Vitro Mammalian Chromosome Aberration Test L.Y. Wei, J.S. Chao, and C.C. Hong, Assessment of the Ability of Propoxur, Methomyl, and Aldicarb, Three Carbamate Insecticides, to Induce Micronuclei In Vitro in Cultured Chinese Hamster Ovary Cells and In Vivo in BALB/c Mice, Environmental and Molecular Mutagenesis 29:386–393 (1997) 2185-92-4 2-Biphenylamine hydrochloride Cl_Nc1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193 912-60-7 Noscapine hydrochloride CN{+}1(.Cl{-})CCc2cc3c(c(OC)c2C{P+}1C{P-}1c2ccc(OC)c(OC)c2C(=O)O1)OCO3 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan