CAS Chem.name Chem.SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 90-30-2 n-phenyl-1-naphthylamine c1ccccc1Nc1cccc2ccccc12 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 95-64-7 3,4-Xylidine Cc1ccc(N)cc1C negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 97-56-3 C.I. Solvent Yellow 3 Cc1ccccc1N=Nc1ccc(N)c(C)c1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 101-67-7 4,4'-Dioctyldiphenylamine CCCCCCCCc1ccc(Nc2ccc(CCCCCCCC)cc2)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 101-96-2 N,N'-Di-sec-butyl-p-phenylenediamine CCC(C)Nc1ccc(NC(C)CC)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-44-1 3-Aminotoluene Cc1cccc(N)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 121-14-2 2,4-Dinitrotoluene (purified) Cc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 122-39-4 N-Phenylbenzenamine c1ccccc1Nc1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005 611-06-3 2,4-Dichloronitrobenzene [O-][N+](=O)c1ccc(Cl)cc1Cl negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1582-09-8 trifluralin CCCN(CCC)c1c(cc(cc1[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-88-7 4-isopropylaniline;_p-Isopropylaniline CC(C)c1ccc(N)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 6448-95-9 Pigment red 22 Cc1ccc(cc1N=Nc1c(O)c(cc2ccccc12)C(=O)Nc1ccccc1)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 55-80-1 3-Methyl-4'-(dimethylamino)azobenzene Cc1cccc(N=Nc2ccc(N(C)C)cc2)c1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 86-30-6 N-Nitrosodiphenylamine O=NN(c1ccccc1)c1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-59-2 2,3-Xylidine Cc1cccc(N)c1C negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-51-2 o-Chloroaniline Nc1ccccc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 97-52-9 benzenamine, 2-methoxy-4-nitro- COc1cc(ccc1N)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-09-2 m-nitroaniline Nc1cccc(c1)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 106-47-8 p-Chloroaniline Nc1ccc(Cl)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-69-0 3,5-Xylidine Cc1cc(C)cc(N)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 134-32-7 1-Naphthylamine Nc1cccc2ccccc12 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 135-88-6 Phenyl-Beta-Naphthylamine c1ccccc1Nc1ccc2ccccc2c1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 554-00-7 2,4-Dichloroaniline Nc1ccc(Cl)cc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 54-88-6 n,n-dimethyl-4-(phenylazo)-m-toluidine Cc1cc(N(C)C)ccc1N=Nc1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 90-94-8 4,4-bis(dimethylamino)benzophenone CN(C)c1ccc(C(=O)c2ccc(N(C)C)cc2)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test NTP 1990; Lafi et al. 1986 91-23-6 o-nitroanizole COc1ccccc1[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 100-17-4 4-nitroanisole COc1ccc(cc1)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 2429-74-5 c.i. direct blue 15 COc1cc(-c2ccc(NN=C3C(S(=O)(=O)O{-}.[Na]{+})=Cc4cc(S(=O)(=O)O{-}.[Na]{+})cc(N)c4C3=O)c(OC)c2)ccc1NN=C1C(S(=O)(=O)O{-}.[Na]{+})=Cc2cc(S(=O)(=O)O{-}.[Na]{+})cc(N)c2C1=O negative negative in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175. 16071-86-6 c.i. direct brown 95 O=C1C=CC(=NNc2cc3ccc2O{-}.[Cu]{2+}.O{-}S3(=O)=O)C(=O)C1=NNc1ccc(-c2ccc(N=Nc3ccc(O{-}.[Na]{+})c(C(=O)O{-}.[Na]{+})c3)cc2)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175. 33229-34-4 hc blue no. 2 OCCNc1ccc(cc1[N+]([O-])=O)N(CCO)CCO negative negative in Vitro Mammalian Chromosome Aberration Test Loveday, K.S., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: Results with 46 chemicals. Environ. Mol. Mutagen., 1990, 16(4), 272-303. 26021-57-8 Hydroxybenzomorpholine Oc1ccc2c(c1)NCCO2 negative negative in Vitro Mammalian Chromosome Aberration Test SCCP (Scientific Committee on Consumer Products), Opinion on Hydroxybenzomorpholine, 20 June 2006. 81612-54-6 HC Orange no. 3 OCCNc1ccc(OCC(O)CO)cc1[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning HC Orange No. 3 Colipa No. B68, European Commission, 24 – 25 June 2003; http://ec.europa.eu/food/fs/sc/sccp/out214_en.pdf 34432-92-3 n-ethyl-n-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline CCN(CCOC(C)OCC(C)C)c1ccc(N=Nc2ccccc2)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test N-Ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline, CAS No 34432-92-3. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/5682 1229-55-6 solvent red 1 COc1ccccc1N=Nc1c2ccccc2ccc1O negative negative in Vitro Mammalian Chromosome Aberration Test Brooks, A.L., Seiler, F.A., Hanson, R.L., Henderson, R.F., In vitro genotoxicity of dyes present in colored smoke munitions. Environ. Mol. Mutagen., 1989, 13(4), 304-313. 74-31-7 N,N'-Diphenyl-p-Phenylenediamine c1ccccc1Nc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 89-61-2 1,4-Dichloro-2-nitrobenzene [O-][N+](=O)c1cc(Cl)ccc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 90-04-0 o-Anisidine COc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-05-0 N,N-Diethyl-p-Phenylenediamine CCN(CC)c1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-46-9 N,N'-Di-2-Naphthyl-P-Phenylenediamine c1cccc2ccc(Nc3ccc(Nc4ccc5ccccc5c4)cc3)cc12 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 97-00-7 2,4-Dinitrochlorobenzene [O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-98-9 N,N-Dimethyl-p-Phenylenediamine CN(C)c1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 100-22-1 N,N,N',N'-Tetramethyl-p-Phenylenediamine CN(C)c1ccc(N(C)C)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 100-61-8 Methyl-phenyl-amine CNc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-14-4 4,4'-Methylenebis(2-Chloroaniline) Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-70-2 4,4'-Dimethoxydiphenylamine COc1ccc(Nc2ccc(OC)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 101-72-4 N-Phenyl-N'-isopropyl-p-phenylenediamine CC(C)Nc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-73-5 p-Isopropoxydiphenylamine CC(C)Oc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 103-69-5 N-Ethylaniline CCNc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 104-94-9 p-Anisidine COc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 128-95-0 1,4-Diamino-anthraquinone Nc1ccc(N)c2c1C(=O)c1ccccc1C2=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 156-43-4 p-Phenetidine CCOc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 494-03-1 chlornaphazine ClCCN(CCCl)c1ccc2ccccc2c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 536-90-3 m-Anisidine COc1cccc(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 793-24-8 N-1,3-Dimethylbutyl-N'-phenyl-p-phenylenediamine CC(C)CC(C)Nc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 3209-22-1 2,3-Dichloronitrobenzene [O-][N+](=O)c1cccc(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 42397-64-8 1,6-Dinitropyrene [O-][N+](=O)c1ccc2ccc3c(ccc4ccc1c2c34)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 42397-65-9 1,8-Dinitropyrene [O-][N+](=O)c1ccc2ccc3ccc(c4ccc1c2c34)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-62-7 2,6-Xylidine Cc1cccc(C)c1N positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-53-4 2-methylbenzenamine Cc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 2650-18-2 C.I. Acid Blue 9 CCN(Cc1cccc(S(=O)(=O)O{-}.N{+})c1)c1ccc(C2=C3C=CC(C=C3)=N{+}(CC)(Cc3cccc(S(=O)(=O)O{-}.N{+})c3).O{-}S(=O)(=O)c3ccccc23)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 7532-20-9 1,3-Dinitropyrene [O-][N+](=O)c1cc(c2ccc3cccc4ccc1c2c34)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 38604-70-5 1-Acetyl-1-methyl-2-phenylhydrazine CC(=O)N(C)Nc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 106-49-0 4-Aminotoluene; p-toluidine Cc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 117-79-3 2-Aminoanthraquinone Nc1ccc2c(c1)C(=O)c1ccccc1C2=O positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996 2465-27-2 Auramine hydrochloride Cl_CN(C)c1ccc(C(=N)c2ccc(N(C)C)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Au, W., and T.C. Hsu (1979) Environ. Mutagen., 1, 27-35. 100-00-5 1-Chloro-4-nitrobenzene [O-][N+](=O)c1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 2475-45-8 c.i. disperse blue 1 Nc1ccc(N)c2c1C(=O)c1c(N)ccc(N)c1C2=O positive positive in Vitro Mammalian Chromosome Aberration Test Anderson, Be., Zeiger, E., Shelby, Md., Resnick, Ma., Gulati, Dk., Ivett, Jl. And Loveday, Ks.; Chromosome Aberration And Sister Chromatid Exchange Test Results With 42 Chemicals; Environ.Mol. Mutagen. 16(Suppl. 18):55-137, 1990 99-54-7 3,4-dichloronitrobenzene [O-][N+](=O)c1ccc(Cl)c(Cl)c1 positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005 119-93-7 Orthotolidine Cc1cc(-c2ccc(N)c(C)c2)ccc1N positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 20721-50-0 2,2'-((4-((4-Aminophenyl)azo)phenyl)imino)bisethanol Nc1ccc(N=Nc2ccc(N(CCO)CCO)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety OPINION ON Disperse Black 9 COLIPA n C106 The SCCS adopted this opinion at its 6th plenary meeting of 23 March 2010 4926-55-0 2-[(2-nitrophenyl)amino]ethanol OCCNc1ccccc1[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety SCCS OPINION ON HC Yellow n 2 COLIPA n B41.The SCCS adopted this opinion at its 8th plenary meeting of 21 September 2010 122-66-7 Hydrazobenzene c1ccccc1NNc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 100-01-6 4-nitroaniline Nc1ccc(cc1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 101-80-4 4,4'-oxydianiline Nc1ccc(Oc2ccc(N)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 100-63-0 phenylhydrazine NNc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL. 2), 2000 137-17-7 2,4,5-trimethylaniline; trimethylaniline, 2,4,5-; 2,4,5trimethylaniline[1] Cc1cc(C)c(C)cc1N positive positive in Vitro Mammalian Chromosome Aberration Test LOVEDAY,KS ANDERSON,BE RESNICK,MA ZEIGER,E; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO, V: RESULTS WITH 46 CHEMICALS; ENVIRON. MOL. MUTAGEN. 16(9):272-303, 1990 13552-44-8 Methylenedianiline dihydrochloride Cl_Cl_Nc1ccc(Cc2ccc(N)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 7220-79-3 Methylene Blue trihydrate CN(C)c1ccc2c(c1)s{+}(.Cl{-})c1cc(N(C)C)ccc1n2_O_O_O positive positive in Vitro Mammalian Chromosome Aberration Test NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYLENE BLUE TRIHYDRATE (CAS NO. 7220-79-3) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) National Toxicology Program P.O. Box 12233 Research Triangle Park, NC 27709 May 2008 NTP TR 540 NIH Publication No. 08-4429 National Institutes of Health Public Health Service U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES 140-56-7 fenaminosulf CN(C)c1ccc(N=NS(=O)(=O)O{-}.[Na]{+})cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tezuka, H., Ando, N., Suzuki, R., Terahata, M., Moriya, M., Shirasu, Y., Sister-chromatid exchanges and chromosomal aberrations in cultured Chinese hamster cells treated with pesticides 1 in microbial reversion assays. Mutat. Res., 1980, 78(2), 177-191. 54381-08-7 HC Orange no. 1 Oc1ccc(Nc2ccccc2[N+]([O-])=O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Safety Assessment of HC Orange No. 1 as Used in Cosmetics, CIR EXPERT PANEL MEETING MARCH 18-19, 2013 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(N=Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate, M. Jr, Harnois, M.C., Sofuni, T., A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 1988, 195(2), 151-213. 1552-42-7 6-dimethylamino-3,3-bis(4-dimethylaminophenyl)phthalide; Crystal violet lactone CN(C)c1ccc(C2(c3ccc(N(C)C)cc3)c3ccc(N(C)C)cc3C(=O)O2)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 842-07-9 c.i. solvent yellow 14 Oc1ccc2ccccc2c1N=Nc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ. Mol. Mutagen., 1989,14(3),165-187.