CAS Chem.name Chem.SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 106-46-7 1,4-Dichlorobenzene Clc1ccc(Cl)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 122-39-4 N-Phenylbenzenamine c1ccccc1Nc1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005 135-88-6 Phenyl-Beta-Naphthylamine c1ccccc1Nc1ccc2ccccc2c1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1570-64-5 4-Chloro-2-methyl-phenol Cc1cc(Cl)ccc1O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 88-60-8 phenol,_2-(1,1-dimethylethyl)-5-methyl- Cc1ccc(C(C)(C)C)c(O)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 88-18-6 2-(1,1-dimethylethyl)phenol CC(C)(C)c1ccccc1O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 137-09-7 2,4-diaminophenol.2hcl Cl_Cl_Nc1ccc(O)c(N)c1 negative negative in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175. 50-07-7 mitomycin CC1=C(N)C(=O)C2C(COC(N)=O)C3(OC)C4C(CN3C=2C1=O)N4 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 63-25-2 carbaryl CNC(=O)Oc1cccc2ccccc12 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 65-45-2 Salicylamide NC(=O)c1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 74-31-7 N,N'-Diphenyl-p-Phenylenediamine c1ccccc1Nc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 92-88-6 [1,1'-biphenyl]-4,4'-diol Oc1ccc(-c2ccc(O)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 93-46-9 N,N'-Di-2-Naphthyl-P-Phenylenediamine c1cccc2ccc(Nc3ccc(Nc4ccc5ccccc5c4)cc3)cc12 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 97-53-0 1-Allyl-3-Methoxy-4-Hydroxybenzene COc1cc(CC=C)ccc1O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 101-70-2 4,4'-Dimethoxydiphenylamine COc1ccc(Nc2ccc(OC)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 101-72-4 N-Phenyl-N'-isopropyl-p-phenylenediamine CC(C)Nc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-73-5 p-Isopropoxydiphenylamine CC(C)Oc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 106-50-3 p-Phenylenediamine Nc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-39-4 m-Cresol Cc1cccc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 118-79-6 2,4,6-Tribromophenol Oc1c(Br)cc(Br)cc1Br positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 154-23-4 Catechin OC1Cc2c(cc(O)cc2O)OC1c1ccc(O)c(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 637-07-0 Clofibrate CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 793-24-8 N-1,3-Dimethylbutyl-N'-phenyl-p-phenylenediamine CC(C)CC(C)Nc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 882-09-7 Colfibric_acid CC(C)(C(O)=O)Oc1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 1129-41-5 3-Methylphenyl_N-methylcarbamate Cc1cccc(OC(=O)NC)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 7090-25-7 Nitrosocarbaryl CN(C(=O)Oc1cccc2ccccc12)N=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 58139-35-8 3-Methylphenyl N-nitroso N-methylcarbamate Cc1cccc(OC(=O)N(C)N=O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate Jr., M., and S. Odashima (1977) Mutation Res.,48, 337-354. 2581-34-2 4-Nitro-3-cresol Cc1cc(O)ccc1[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 2416-94-6 2,3,6-trimethylphenol Cc1ccc(C)c(C)c1O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1333-16-0 Bisphenol F (mixed isomers) Oc1ccccc1Cc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 620-92-8 4,4'-Methylenebis(phenol) Oc1ccc(Cc2ccc(O)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-95-4 2,4,5-Trichlorophenol Oc1cc(Cl)c(Cl)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test Armstrong MJ, et. al., 2,4,6-Trichlorophenol (TCP) induces chromosome breakage and aneuploidy in vitro, Mutat Res,303(3),1993,101-108 620-17-7 Phenol, 3-ethyl- CCc1cccc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test SCREENING-LEVEL HAZARD CHARACTERIZATION OF HIGH PRODUCTION VOLUME CHEMICALS, March, 2008, INTERIM 80-05-7 4,4'-Isopropylidenediphenol CC(C)(c1ccc(O)cc1)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tayama S., Nakagava Y., Tayama K., Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells, Mutat. Research649 (2008), 114-125Issues 1-2 89-72-5 O-sec-Butylphenol CCC(C)c1ccccc1O positive positive in Vitro Mammalian Chromosome Aberration Test M.Matsumoto, et.al, Bull.Natl.Inst. health Sci., 2011,129, 68-75 120-83-2 2,4-Dichlorophenol Oc1ccc(Cl)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test HILLIARD,CA et al ; ENVIRON. MOL. MUTAGEN. 31(4):316-326, 1998 99-71-8 Phenol,_4-(1-methylpropyl)- CCC(C)c1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Kusakabe, H., Yamakage, K., Wakuri, S., Sasaki, K., Nakagawa, Y., Watanabe, M., Hayashi, M., Sofuni, T., Ono, H., Tanaka, N., Relevance of chemical structure and cytotoxicity to the induction of chromosome aberrations based on the testing results of 98 high production volume industrial chemicals. Mutat. Res., 2002, 517(1-2), 187-198. 59-92-7 Levodopa NC(Cc1ccc(O)c(O)c1)C(O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 90-43-7 1,1'-biphenyl-2-ol Oc1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Tayama-Nawai, S., Yoshida, S., Nakao, T., Hiraga, K., Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol. Mutat. Res., 1984, 141(2), 95-99. 117-39-5 Quercetin Oc1ccc(C2=C(O)C(=O)c3c(cc(O)cc3O)O2)cc1O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 132-27-4 O-Phenylphenate Sodium [Na]{+}.O{-}c1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test ortho-PHENYLPHENOL AND ITS SODIUM SALT, IARC MONOGRAPHS VOLUME 73, p.451-480; Tayama, S. & Nakagawa, Y., Mutat. Res., 1991, 259, 1–12 555-30-6 2-methyl-3-(3,4-dihydroxyphenyl)-L-alanine CC{P+}(N)(Cc1ccc(O)c(O)c1)C(O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 933-75-5 2,3,6-trichlorophenol Oc1c(Cl)ccc(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test SOFUNI,T, et al; A COMPARISON OF CHROMOSOME ABERRATION INDUCTION BY 25 COMPOUNDS TESTED BY TWO CHINESE HAMSTER CELL (CHL AND CHO) SYSTEMS IN CULTURE; MUTAT. RES. 241(2), 1990, 175-213 1079-21-6 2,5-Dihydroxybiphenyl Oc1ccc(O)cc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test S.Tayama et al., Mutat.Res., 1989, 223(1), 23-33 58-90-2 2,3,4,6-Tetrachlorophenol Oc1c(Cl)cc(Cl)c(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test WORLD HEALTH ORGANIZATION, INTERNATIONAL AGENCY FOR RESEARCH ON CANCER - IARC, MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide VOLUME 71, p.796-816 95-70-5 2,5-diaminotoluene Cc1cc(N)ccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Products OPINION ON Toluene-2,5-diamine COLIPA n A5 The SCCP adopted this opinion at its 13th plenary meeting on 2 October 2007 609-20-1 2,6-dichloro-p-phenylenediamine Nc1cc(Cl)c(N)c(Cl)c1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 87-66-1 pyrogallol (1,2,3-trihydroxybenzene) Oc1cccc(O)c1O positive positive in Vitro Mammalian Chromosome Aberration Test SILVA,MDC GASPAR,J SILVA,ID LEAO,D AND RUEFF,J INDUCTION OF CHROMOSOMAL ABERRATIONS BY PHENOLIC COMPOUNDS: POSSIBLE ROLE OF REACTIVE OXYGEN SPECIES; MUTAT. RES. 540(1):29-42, 2003 105-11-3 p-quinone dioxime ON=C1C=CC(=NO)C=C1 positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL. 2), 2000 118-75-2 tetrachloro-1,4-benzoquinone O=C1C(Cl)=C(Cl)C(=O)C(Cl)=C1Cl positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005 68-76-8 triaziquone O=C1C=C(N2CC2)C(=O)C(N2CC2)=C1N1CC1 positive positive in Vitro Mammalian Chromosome Aberration Test M. Ishidate Jr., et. al. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutation Research, 195 (1988) 151-213 106-44-5 p-cresol Cc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test p-Cresol, CAS No 106-44-5. ECHA Legal notice, Registration dossier. https://echa.europa.eu/registration-dossier/-/registered-dossier/15980 11121-48-5 C. I. acid red 94; Rose Bengal O=C1C(I)=CC2=C(c3c(Cl)c(Cl)c(Cl)c(Cl)c3C(=O)O{-}.K{+})c3cc(I)c(O{-}.K{+})c(I)c3OC2=C1I positive positive in Vitro Mammalian Chromosome Aberration Test William Au and T. C. Hsu, Studies on the Clastogenic Effects of Biologic Stains and Dyes, Environmental Mutagenesis 1: 27-35 (1979); M. Ishidate Jr., M.C. Harnois and T. Sofuni, A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutation Research, 195 (1988) 151-213 842-07-9 c.i. solvent yellow 14 Oc1ccc2ccccc2c1N=Nc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ. Mol. Mutagen., 1989,14(3),165-187. 39156-41-7 2,4-Diaminoanisole Sulfate COc1ccc(N)cc1N_OS(O)(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 16423-68-0 Erythrosine sodium O=C1C(I)=CC2=C(c3ccccc3C(=O)O{-}.[Na]{+})c3cc(I)c(O{-}.[Na]{+})c(I)c3OC2=C1I positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan