CAS Chem.name Chem.SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 81-15-2 trinitro-t-butyl xylene Cc1c(c(C)c(c(c1[N+]([O-])=O)C(C)(C)C)[N+]([O-])=O)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-29-6 Cinnamyl Anthranilate Nc1ccccc1C(=O)OCC=Cc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 95-64-7 3,4-Xylidine Cc1ccc(N)cc1C negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 97-56-3 C.I. Solvent Yellow 3 Cc1ccccc1N=Nc1ccc(N)c(C)c1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 98-95-3 Nitrobenzene [O-][N+](=O)c1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-44-1 3-Aminotoluene Cc1cccc(N)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 121-14-2 2,4-Dinitrotoluene (purified) Cc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 535-87-5 1,5-Diaminobenzoic acid Nc1cc(N)cc(c1)C(O)=O negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 611-06-3 2,4-Dichloronitrobenzene [O-][N+](=O)c1ccc(Cl)cc1Cl negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1582-09-8 trifluralin CCCN(CCC)c1c(cc(cc1[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 127-68-4 3-Nitro-benzenesulfonic_acid OS(=O)(=O)c1cccc(c1)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 5281-04-9 C.I. Pigment Red 57, calcium salt (1:1) [Ca+2].Cc1ccc(N=Nc2c(O)c(cc3ccccc32)C([O-])=O)c(c1)S([O-])(=O)=O negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 121-03-9 2-Methyl-5-nitrobenzenesulfonic acid Cc1ccc(cc1S(O)(=O)=O)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-88-7 4-isopropylaniline;_p-Isopropylaniline CC(C)c1ccc(N)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 584-84-9 Toluene 2,4-diisocyanate Cc1ccc(cc1N=C=O)N=C=O negative negative in Vitro Mammalian Chromosome Aberration Test GULATI,DK. et al; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 55-80-1 3-Methyl-4'-(dimethylamino)azobenzene CN(C)c1ccc(cc1)N=Nc1cccc(C)c1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-59-2 2,3-Xylidine Cc1cccc(N)c1C negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 88-44-8 4-amino-m-toluenesulfonic acid Cc1ccc(N)c(c1)S(O)(=O)=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-51-2 o-Chloroaniline Nc1ccccc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 97-52-9 benzenamine, 2-methoxy-4-nitro- COc1cc(ccc1N)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 99-09-2 m-nitroaniline Nc1cccc(c1)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-68-8 4,4'-Diphenylmethane Diisocyanate O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 106-47-8 p-Chloroaniline Nc1ccc(Cl)cc1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-69-0 3,5-Xylidine Cc1cc(C)cc(N)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 121-47-1 3-Amino-benzenesulfonic_acid Nc1cccc(c1)S(O)(=O)=O negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 554-00-7 2,4-Dichloroaniline Nc1ccc(Cl)cc1Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 26630-87-5 Disperse Red 206 CC(=O)OCCN(CCOC(C)=O)c1ccc(N=Nc2nc3ccc(Cl)cc3s2)c(NC(=O)c2ccccc2)c1 negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1918-16-7 propachlor CC(C)N(C(=O)CCl)c1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test UNITED STATES ENVIRONMENTAL PROTECTION AGENCY, Prevention, Pesticides And Toxic Substances (7508C), EPA 738-R-015, November 1998 102-36-3 3,4-Dichlorophenyl isocyanate Clc1ccc(cc1Cl)N=C=O negative negative in Vitro Mammalian Chromosome Aberration Test http://apps.echa.europa.eu/registered/data/dossiers/DISS-a13473ac-d753-67db-e044-00144f67d031/AGGR-8effb176-5f7e-45aa-bbda-d8fb05fc581b_DISS-a13473ac-d753-67db-e044-00144f67d031.html#AGGR-8effb176-5f7e-45aa-bbda-d8fb05fc581b 54-88-6 n,n-dimethyl-4-(phenylazo)-m-toluidine CN(C)c1ccc(N=Nc2ccccc2)c(C)c1 negative positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 90-41-5 2-aminobiphenyl (2-phenylaniline) Nc1ccccc1-c1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test http://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF90-41-5f.pdf 90-94-8 4,4-bis(dimethylamino)benzophenone CN(C)c1ccc(cc1)C(=O)c1ccc(cc1)N(C)C negative positive in Vitro Mammalian Chromosome Aberration Test NTP 1990; Lafi et al. 1986 91-23-6 o-nitroanizole COc1ccccc1[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 100-17-4 4-nitroanisole COc1ccc(cc1)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology and Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 570-24-1 1-amino-2-methyl-6-nitrobenzene Cc1cccc(c1N)[N+]([O-])=O negative positive in Vitro Mammalian Chromosome Aberration Test Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning 6-Nitro-O-Toluidine COLIPA N B56 Adopted By The SCCNFP During The 24th Plenary Meeting Of 24-25 June 2003 121-73-3 1-chloro-3-nitrobenzene [O-][N+](=O)c1cccc(Cl)c1 negative negative in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175. 569-61-9 c.i. basic red 9 monohydrochloride Cl.Nc1ccc(cc1)C(c1ccc(N)cc1)=C1C=CC(=N)C=C1 negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of C.I. Basic Red 9 Monohydrochloride (Pararosaniline) (CAS No. 569-61-9) In F344/N Rats and B6C3F1 Mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1986, 285, 1-228. 16071-86-6 c.i. direct brown 95 [Na+].[Na+].[Cu+2].[O-]C(=O)c1cc(ccc1[O-])N=Nc1ccc(cc1)-c1ccc(NN=C2C(=O)C=CC(=NNc3cc(ccc3[O-])S([O-])(=O)=O)C2=O)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175. 137-09-7 2,4-diaminophenol.2hcl Cl.Cl.Nc1ccc(O)c(N)c1 negative negative in Vitro Mammalian Chromosome Aberration Test Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., et al., Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 1987, 10(Suppl. 10), 1-175. 33229-34-4 hc blue no. 2 OCCNc1ccc(cc1[N+]([O-])=O)N(CCO)CCO negative negative in Vitro Mammalian Chromosome Aberration Test Loveday, K.S., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: Results with 46 chemicals. Environ. Mol. Mutagen., 1990, 16(4), 272-303. 82576-75-8 ethanol, 2-[(4-amino-2-methyl-5-nitrophenyl)amino]- Cc1cc(N)c(cc1NCCO)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Kirkland: SCCP/1025/06, Opinion on HC Violet n 1, COLIPA N B66, June 2006 http://ec.europa.eu/health/archive/ph_risk/committees/04_sccp/docs/sccp_o_063.pdf Last accessed 25.02.2016 2608-48-2 5-(4-nitrophenyl)-2,4-pentadienal [O-][N+](=O)c1ccc(C=CC=CC=O)cc1 negative negative in Vitro Mammalian Chromosome Aberration Test Zeiger, E., Shelby, M.D., Ivett, J., McFee, A.F., Mutagenicity testing of 5-(4-nitrophenyl)-2,4-pentadien-1-al (spy dust) and its metabolites in vitro and in vivo. Environ. Mutagen., 1987, 9(3), 269-280. 96-91-3 4,6-dinitro-2-aminophenol Nc1cc(cc(c1O)[N+]([O-])=O)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test SCCS (Scientific Committee on Consumer Safety), Opinion on picramic acid and sodium picramate, 14 December 2010. 81612-54-6 HC Orange no. 3 OCCNc1ccc(OCC(O)CO)cc1[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning HC Orange No. 3 Colipa No. B68, European Commission, 24 – 25 June 2003; http://ec.europa.eu/food/fs/sc/sccp/out214_en.pdf 54381-16-7 ethanol, 2,2'-o(4-aminophenyl)iminoabis-, sulfate (1:1) (salt) OS(O)(=O)=O.Nc1ccc(cc1)N(CCO)CCO negative positive in Vitro Mammalian Chromosome Aberration Test European Commission Health & Consumer Protection Directorate-GeneraL Directorate C - Public Health and Risk Assessment C7 - Risk assessment Scientific Committee On Consumer Products Opinion on N,N-bis(2-hydroxyethyl)-p-phenylenediamine sulfate COLIPA N A50. Adopted by the SCCP during the 8th plenary meeting of 20 June 2006 136-40-3 Phenazopyridine hydrochloride Cl.Nc1ccc(\N=N\c2ccccc2)c(N)n1 negative positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 599-79-1 Sulfasalazine OC(=O)c1cc(ccc1O)N=Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1 negative negative in Vitro Mammalian Chromosome Aberration Test Bishop, J.B., Witt, K.L., Gulati, D.K., MacGregor, J.T., Evaluation of the mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP). Mutagenesis, 1990, 5(6), 549-554. 1936-15-8 c.i. acid orange 10 [Na+].[Na+].Oc1ccc2cc(cc(c2c1N=Nc1ccccc1)S([O-])(=O)=O)S([O-])(=O)=O negative positive in Vitro Mammalian Chromosome Aberration Test Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ. Mol. Mutagen., 1989, 14(3), 165-187. 2512-29-0 butanamide, 2-[(4-methyl-2-nitrophenyl)azo]-3-oxo-n-phenyl- CC(=O)C(N=Nc1ccc(C)cc1[N+]([O-])=O)C(=O)Nc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test 2-[(4-Methyl-2-nitrophenyl)azo]-3-oxo-N-phenylbutyramide, CAS No 2512-29-0. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/13177/1 34432-92-3 n-ethyl-n-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline CCN(CCOC(C)OCC(C)C)c1ccc(cc1)N=Nc1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test N-Ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline, CAS No 34432-92-3. ECHA Legal notice, Registration dossier. http://echa.europa.eu/registration-dossier/-/registered-dossier/5682 51-28-5 2,4-Dinitro-phenol Oc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 88-53-9 benzenesulfonic_acid,_2-amino-5-chloro-4-methyl- Cc1cc(N)c(cc1Cl)S(O)(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 88-89-1 Picric Acid Oc1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 89-61-2 1,4-Dichloro-2-nitrobenzene [O-][N+](=O)c1cc(Cl)ccc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 90-04-0 o-Anisidine COc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-05-0 N,N-Diethyl-p-Phenylenediamine CCN(CC)c1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 93-68-5 butanamide,_n-(2-methylphenyl)-3-oxo- CC(=O)CC(=O)Nc1ccccc1C positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 95-54-5 o-Phenylenediamine Nc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 97-00-7 2,4-Dinitrochlorobenzene [O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-56-9 4-Nitro-o-Phenylenediamine Nc1ccc(cc1N)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-57-0 2-Amino-4-Nitrophenol Nc1cc(ccc1O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 99-98-9 N,N-Dimethyl-p-Phenylenediamine CN(C)c1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 100-22-1 N,N,N',N'-Tetramethyl-p-Phenylenediamine CN(C)c1ccc(cc1)N(C)C positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 100-61-8 Methyl-phenyl-amine CNc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-14-4 4,4'-Methylenebis(2-Chloroaniline) Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 101-72-4 N-Phenyl-N'-isopropyl-p-phenylenediamine CC(C)Nc1ccc(Nc2ccccc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 103-69-5 N-Ethylaniline CCNc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 104-94-9 p-Anisidine COc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 106-50-3 p-Phenylenediamine Nc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 108-45-2 m-Phenylenediamine Nc1cccc(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 121-88-0 2-Amino-5-Nitrophenol Nc1ccc(cc1O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 123-30-8 4-Aminophenol Nc1ccc(O)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 156-43-4 p-Phenetidine CCOc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 536-90-3 m-Anisidine COc1cccc(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 591-27-5 3-Aminophenol Nc1cccc(O)c1 positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1934-21-0 Acid Yellow 23 OC(=O)C1=NN(C(=O)C1N=Nc1ccc(cc1)S(O)(=O)=O)c1ccc(cc1)S(O)(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 3209-22-1 2,3-Dichloronitrobenzene [O-][N+](=O)c1cccc(Cl)c1Cl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 5307-14-2 2-Nitro-p-Phenylenediamine Nc1ccc(N)c(c1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 15972-60-8 Alachlor CCc1cccc(CC)c1N(COC)C(=O)CCl positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 15481-70-6 Toluene-2,6-diamine, dihydrochloride Cl.Cl.Cc1c(N)cccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 823-40-5 2,6-diaminotoluene Cc1c(N)cccc1N positive positive in Vitro Mammalian Chromosome Aberration Test ARMSTRONG,MJ, BEAN,CL AND GALLOWAY,SM; A QUANTITATIVE ASSESSMENT OF THE CYTOTOXICITY ASSOCIATED WITH CHROMOSOMAL ABERRATION DETECTION IN CHINESE HAMSTER OVARY CELLS; MUTAT. RES. 265(1):45-60, 1992 25956-17-6 C.I._Food_Red_17 [Na+].[Na+].COc1cc(c(C)cc1N=Nc1c(O)ccc2cc(ccc21)S([O-])(=O)=O)S([O-])(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 87-62-7 2,6-Xylidine Cc1cccc(C)c1N positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 824-78-2 p-Nitrophenol sodium salt [Na+].[O-]c1ccc(cc1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 91-08-7 2,6-Toluene diisocyanate Cc1c(cccc1N=C=O)N=C=O positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK.et al; III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989; JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996 95-53-4 2-methylbenzenamine Cc1ccccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 91-97-4 Bitolylene diisocyanate Cc1cc(ccc1N=C=O)-c1ccc(N=C=O)c(C)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology Toxicology & Information Center, Japan (JETOC), Mutagenicity Test Data of Existing Chemical Substances, 1995/12/31; Test guideline equivalent or similar to OECD Guideline 473 (In vitro Mammalian Chromosome Aberration Test) and EU Method B.10 (Mutagenicity - In Vitro Mammalian Chromosome Aberration Test); http://apps.echa.europa.eu/registered/data/dossiers/DISS-9d9568c1-3c26-0b72-e044-00144f67d249/AGGR-6ce1eaf3-4cda-40c4-93ac-8c7f98960912_DISS-9d9568c1-3c26-0b72-e044-00144f67d249.html#GEN_RESULTS_HD 88-85-7 dinoseb CCC(C)c1cc(cc(c1O)[N+]([O-])=O)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Dinoseb- Study Report, ECHA Europa, OECD Gideline 473, February 2006; http://apps.echa.europa.eu/registered/data/dossiers/DISS-9d9d5546-37af-1230-e044-00144f67d249/AGGR-5d90f38f-b418-4186-af54-407fd3c8d17b_DISS-9d9d5546-37af-1230-e044-00144f67d249.html#GEN_DATA_SOURCE_HD 2650-18-2 C.I. Acid Blue 9 [NH4+].[NH4+].CCN(Cc1cccc(c1)S([O-])(=O)=O)c1ccc(cc1)C(=C1C=CC(C=C1)=[N+](CC)Cc1cccc(c1)S([O-])(=O)=O)c1ccccc1S([O-])(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 23184-66-9 Butachlor CCCCOCN(C(=O)CCl)c1c(CC)cccc1CC positive positive in Vitro Mammalian Chromosome Aberration Test Lin MF, Wu CL, Wang TC, Pesticide clastogenicity in CHO cells, Mutat. Res., 1987 Jul; 188(3):241-50 106-49-0 4-Aminotoluene; p-toluidine Cc1ccc(N)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate et. al. Mutat. Res., 1988, 195 (2), 151-213. 16055-80-4 L-Kynurenine_sulfate OS(O)(=O)=O.N[C@H](CC(=O)c1ccccc1N)C(O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 2783-94-0 FD&C Yellow 6 [Na+].[Na+].Oc1ccc2cc(ccc2c1\N=N\c1ccc(cc1)S([O-])(=O)=O)S([O-])(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 95-85-2 2-Amino-4-chlorophenol Nc1cc(Cl)ccc1O positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 4; 2008 2465-27-2 Auramine hydrochloride Cl.CN(C)c1ccc(cc1)C(=N)c1ccc(cc1)N(C)C positive positive in Vitro Mammalian Chromosome Aberration Test Au, W., and T.C. Hsu (1979) Environ. Mutagen., 1, 27-35. 26381-41-9 Basic brown 16 [Cl-].C[N+](C)(C)c1ccc2ccc(O)c(N=Nc3ccc(N)cc3)c2c1 positive positive in Vitro Mammalian Chromosome Aberration Test OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS; CONCERNING BASIC BROWN 16COLIPA n C9, adopted by the SCCNFP during the 23rd plenary meeting of 18 March 2003 100-00-5 1-Chloro-4-nitrobenzene [O-][N+](=O)c1ccc(Cl)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996 5131-60-2 4-Chloro-m-phenylenediamine Nc1ccc(Cl)c(N)c1 positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; 1996; Loveday, Ks., Anderson, Be., Resnick, Ma., Zeiger, E.; Chromosome Aberration And Sister Chromatid Exchange Tests In Chinese Hamster Ovary Cells In Vitro, V: Results With 46 Chemicals; Environ. Mol. Mutagen. 16(9):272-303, 1990 95-83-0 4-chloro-o-phenylenediamine Nc1ccc(Cl)cc1N positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; 95-80-7 Toluene-2,4-diamine Cc1ccc(N)cc1N positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; 95-70-5 2,5-diaminotoluene Cc1cc(N)ccc1N positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Products OPINION ON Toluene-2,5-diamine COLIPA n A5 The SCCP adopted this opinion at its 13th plenary meeting on 2 October 2007 99-54-7 3,4-dichloronitrobenzene [O-][N+](=O)c1ccc(Cl)c(Cl)c1 positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY-TOXICOLOGY & INFORMATION CENTER (JETOC), JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION SYSTEM OF THE INDUSTRIAL SAFETY AND HEALTH LAW, SUPPLEMENT 3; 2005 609-20-1 2,6-dichloro-p-phenylenediamine Nc1cc(Cl)c(N)c(Cl)c1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 119-93-7 Orthotolidine Cc1cc(ccc1N)-c1ccc(N)c(C)c1 positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 20721-50-0 2,2'-((4-((4-Aminophenyl)azo)phenyl)imino)bisethanol Nc1ccc(cc1)N=Nc1ccc(cc1)N(CCO)CCO positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety OPINION ON Disperse Black 9 COLIPA n C106 The SCCS adopted this opinion at its 6th plenary meeting of 23 March 2010 4926-55-0 2-[(2-nitrophenyl)amino]ethanol OCCNc1ccccc1[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test Scientific Committee on Consumer Safety SCCS OPINION ON HC Yellow n 2 COLIPA n B41.The SCCS adopted this opinion at its 8th plenary meeting of 21 September 2010 88-74-4 2-nitroaniline Nc1ccccc1[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL), 1997 100-01-6 4-nitroaniline Nc1ccc(cc1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 62-23-7 4-nitrobenzoic acid OC(=O)c1ccc(cc1)[N+]([O-])=O positive positive in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CAS No. 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1994 Dec; 442:1-306. 101-80-4 4,4'-oxydianiline Nc1ccc(Oc2ccc(N)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 137-17-7 2,4,5-trimethylaniline; trimethylaniline, 2,4,5-; 2,4,5trimethylaniline[1] Cc1cc(C)c(N)cc1C positive positive in Vitro Mammalian Chromosome Aberration Test LOVEDAY,KS ANDERSON,BE RESNICK,MA ZEIGER,E; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO, V: RESULTS WITH 46 CHEMICALS; ENVIRON. MOL. MUTAGEN. 16(9):272-303, 1990 13552-44-8 Methylenedianiline dihydrochloride Cl.Cl.Nc1ccc(Cc2ccc(N)cc2)cc1 positive positive in Vitro Mammalian Chromosome Aberration Test GULATI,DK, WITT,K, ANDERSON,B, ZEIGER,E AND SHELBY,MD; CHROMOSOME ABERRATION AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE HAMSTER OVARY CELLS IN VITRO. III: RESULTS WITH 27 CHEMICALS; ENVIRON. MOL. MUTAGEN. 13(2):133-193, 1989 140-56-7 fenaminosulf [Na+].CN(C)c1ccc(cc1)N=NS([O-])(=O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Tezuka, H., Ando, N., Suzuki, R., Terahata, M., Moriya, M., Shirasu, Y., Sister-chromatid exchanges and chromosomal aberrations in cultured Chinese hamster cells treated with pesticides 1 in microbial reversion assays. Mutat. Res., 1980, 78(2), 177-191. 2185-92-4 2-Biphenylamine hydrochloride Cl.Nc1ccccc1-c1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193 60-11-7 4-(dimethylamino)azobenzene CN(C)c1ccc(cc1)N=Nc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Ishidate, M. Jr, Harnois, M.C., Sofuni, T., A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 1988, 195(2), 151-213. 85-86-9 2-naphthalenol, 1- 4-(phenylazo)phenyl azo - Oc1ccc2ccccc2c1N=Nc1ccc(cc1)N=Nc1ccccc1 positive positive in Vitro Mammalian Chromosome Aberration Test Au, W, Hsu, T.C., Studies on the clastogenic effects of biologic stains and dyes. Environ. Mutagen., 1979,1(1), 27-35. 1552-42-7 6-dimethylamino-3,3-bis(4-dimethylaminophenyl)phthalide; Crystal violet lactone CN(C)c1ccc(cc1)C1(OC(=O)c2cc(ccc21)N(C)C)c1ccc(cc1)N(C)C negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 6459-94-5 1,3-naphthalenedisulfonic acid, 8-[[3,3-dimethyl-4-[[4-[[(4-methylphenyl)sulfonyl]oxy]phenyl]azo][1,1-biphenyl]-4-yl]azo]-7-hydroxy-, disodium salt [Na+].[Na+].Cc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)\N=N\c1ccc(cc1C)-c1ccc(\N=N\c2c(O)ccc3cc(cc(c32)S([O-])(=O)=O)S([O-])(=O)=O)c(C)c1 negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1991, 405,1-236. 1937-37-7 direct black 38 [Na+].[Na+].Nc1ccc(N=Nc2ccc(cc2)-c2ccc(cc2)N=Nc2c(N)c3c(O)c(N=Nc4ccccc4)c(cc3cc2S([O-])(=O)=O)S([O-])(=O)=O)c(N)c1 negative negative in Vitro Mammalian Chromosome Aberration Test http://ntp.niehs.nih.gov/testing/status/agents/ts-10886-n.html#Genetic-Toxicology 2832-40-8 c.i. disperse yellow 3 CC(=O)Nc1ccc(cc1)N=Nc1cc(C)ccc1O negative negative in Vitro Mammalian Chromosome Aberration Test Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E., Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ. Mol. Mutagen., 1989,14(3),165-187. 2425-85-6 c.i. pigment red 3 Cc1ccc(N=Nc2c(O)ccc3ccccc32)c(c1)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of C.I. Pigment Red 3 (CAS No. 2425-85-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1992, 407, 1-289. 6471-49-4 c.i. pigment red 23 COc1ccc(cc1N=Nc1c(O)c(cc2ccccc21)C(=O)Nc1cccc(c1)[N+]([O-])=O)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CAS No. 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1992, 411, 1-283. 39300-45-3 dinocap CCCCCCC(C)c1cc(cc(c1OC(=O)\C=C\C)[N+]([O-])=O)[N+]([O-])=O negative negative in Vitro Mammalian Chromosome Aberration Test Dinocap, Summary of Toxicological Data, California Department of Food and Agriculture Toxicology Branch; http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/344.pdf 39156-41-7 2,4-Diaminoanisole Sulfate OS(O)(=O)=O.COc1ccc(N)cc1N positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan