CAS Chem.name Chem.SMILES #CA_without_S9 #Obs_CA_with_S9 Bioassay - Reference(s) - 75-34-3 1,1-Dichloroethane CC(Cl)Cl negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 76-44-8 Heptachlor ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 79-27-6 1,1,2,2-Tetrabromoethane BrC(Br)C(Br)Br negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 526-78-3 2,3-Dibromosuccinic acid OC(=O)C(Br)C(Br)C(O)=O negative negative in Vitro Mammalian Chromosome Aberration Test NIHS Japan 75-35-4 Vinylidene Chloride C=C(Cl)Cl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 78-43-3 Tris(dichloropropyl)phosphate O=P(OCC(Cl)CCl)(OCC(Cl)CCl)OCC(Cl)CCl negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 3322-93-8 1-(1,2-Dibromoethyl)-3,4-Dibromocyclohexane BrCC(Br)C1CCC(Br)C(Br)C1 negative positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 112-26-5 1,2-Bis(2-chloroethoxy)ethane ClCCOCCOCCCl negative positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 1918-16-7 propachlor CC(C)N(C(=O)CCl)c1ccccc1 negative positive in Vitro Mammalian Chromosome Aberration Test UNITED STATES ENVIRONMENTAL PROTECTION AGENCY, Prevention, Pesticides And Toxic Substances (7508C), EPA 738-R-015, November 1998 79-01-6 Trichloroethylene ClC=C(Cl)Cl negative negative in Vitro Mammalian Chromosome Aberration Test Danish EPA Inventory, Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test In Vitro, Revised Edition. Life-Science Information Center; Tokyo, Japan. 532-27-4 2-chloroacetophenone O=C(CCl)c1ccccc1 negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone (CAS No. 532-27-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Natl Toxicol Program Tech Rep Ser 1990 Mar; 379:1-191; http://www.pubfacts.com/detail/12692642/NTP-Toxicology-and-Carcinogenesis-Studies-of-2-Chloroacetophenone-CAS-No.-532-27-4-in-F344/N-Rats-an; http://ntp.niehs.nih.gov/results/pubs/longterm/reports/longterm/tr300399/abstracts/tr379/index.html 74-96-4 bromoethane CCBr negative negative in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CAS No. 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1989, 363, 1-186. 62-73-7 Dichlorvos COP(=O)(OC)OC=C(Cl)Cl positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 96-13-9 2,3-Dibromo-1-Propanol OCC(Br)CBr positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 126-72-7 Tris(2,3-Dibromopropyl)Phosphate O=P(OCC(Br)CBr)(OCC(Br)CBr)OCC(Br)CBr positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 154-93-8 carmustine O=C(NCCCl)N(CCCl)N=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 494-03-1 chlornaphazine ClCCN(CCCl)c1ccc2ccccc2c1 positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 542-75-6 1,3-Dichloropropene ClCC=CCl positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 598-72-1 alpha-Bromopropionic_acid CC(Br)C(O)=O positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 616-23-9 2,3-dichloro-1-propanol OCC(Cl)CCl positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 15972-60-8 Alachlor CCc1cccc(CC)c1N(COC)C(=O)CCl positive positive in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 71-55-6 1,1,1-trichloroethane; Ethane, 1,1,1-trichloro-; Chlorten CC(Cl)(Cl)Cl positive positive in Vitro Mammalian Chromosome Aberration Test GALLOWAY,SM, ARMSTRONG, MJ, REUBEN,C, COLMAN,S BROWN,B, CANNON,C, BLOOM,A.D, NAKAMURA,F, AHMED,M. DUK,S, RIMPO,J, MARGOLIN,BH, RESNICK,MA, ANDERSON,B AND ZEIGER,E; CHROMOSOME ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE HAMSTER OVARY CELLS: EVALUATIONS OF 108 CHEMICALS; ENVIRON. MOL. MUTAGEN. 10(SUPPL. 10):1-175, 1987 23184-66-9 Butachlor CCCCOCN(C(=O)CCl)c1c(CC)cccc1CC positive positive in Vitro Mammalian Chromosome Aberration Test Lin MF, Wu CL, Wang TC, Pesticide clastogenicity in CHO cells, Mutat. Res., 1987 Jul; 188(3):241-50 107-06-2 1,2-Dichloroethane ClCCCl positive positive in Vitro Mammalian Chromosome Aberration Test Gregg, N. et al.: 1,2-Dichloroethane, Critria Document for|an Occupational Exposure Limit, HSE, London, 1993; Sofuni, T. et al. (1985): Eisei Shikenjo Hokoku 103, 64 -|75. 78-87-5 1,2-Dichloropropane CC(Cl)CCl positive positive in Vitro Mammalian Chromosome Aberration Test Galloway S., et al., Environ .Mol. Mutagen., 10, 1-75, 1987. 106-93-4 1,2-Dibromoethane BrCCBr positive positive in Vitro Mammalian Chromosome Aberration Test H. Tezuka, N. Ando, R. Suzuki, M. Terahata, M. Moriya, Y. Shirasu, Sister-chromatid exchanges and chromosomal aberrations in cultured Chinese hamster cells treated with pesticides positive in microbial reversion assays. Mutat. Res., 1980, 78(2),177-191. 96-18-4 1,2,3-Trichloropropane ClCC(Cl)CCl positive positive in Vitro Mammalian Chromosome Aberration Test 1,2,3-Trichloropropane, CAS No 96-18-4. NTP Technical Report on the Toxicology and Carcinogenesis Studies in F344/N rats and B6C3F1 Mice (gavage studies). 1993, pp.9, 63 107-05-1 Allyl chloride C=CCCl positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; (SUPPL), 1997 75-26-3 2-bromopropane CC(C)Br positive positive in Vitro Mammalian Chromosome Aberration Test Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst.; JETOC (Ed.) Supp. 2 (2000) (Tables in English) 77439-76-0 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone OC1C(C(Cl)Cl)=C(Cl)C(=O)O1 positive positive in Vitro Mammalian Chromosome Aberration Test MATSUMURA,H, WATANABE,M, MATSUMOTO,K AND OHTA,T; 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) INDUCES GENE MUTATIONS AND INHIBITS METABOLIC COOPERATION IN CULTURED CHINESE HAMSTER CELLS; J. TOXICOL. ENVIRON. HEALTH 43(1):65-72, 1994 13909-09-6 Semustine CC1CCC(NC(=O)N(CCCl)N=O)CC1 positive positive in Vitro Mammalian Chromosome Aberration Test Shah VC, Vyas RC, Adhvaryu SG; Cytogenetic effects of Me-CCNU on sister chromatid exchange frequency, cellular kinetics and chromosome aberrations. Neoplasma [1986, 33(1):33-37] 563-47-3 3-chloro-2-methylprop-1-ene CC(=C)CCl positive positive in Vitro Mammalian Chromosome Aberration Test Japan Chemical Industry Ecology- Toxicology And Information Center, Japan; Mutagenicity Test Data Of Existing Chemical Substances Based On The Toxicity Investigation Of The Industrial Safety And Health Law; (Suppl. 2), 2000 127-00-4 1-chloro-2-propanol CC(O)CCl positive positive in Vitro Mammalian Chromosome Aberration Test NTP Toxicology and Carcinogenesis Studies of 1-Chloro-2-propanol (Technical Grade) (CAS NO. 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies. Natl Toxicol Program Tech Rep Ser. 1998 Sep; 477:1-264 79-43-6 dichloracetic acid OC(=O)C(Cl)Cl positive positive in Vitro Mammalian Chromosome Aberration Test JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN; MUTAGENICITY TEST DATA OF EXISTING CHEMICAL SUBSTANCES BASED ON THE TOXICITY INVESTIGATION OF THE INDUSTRIAL SAFETY AND HEALTH LAW; 1996 107-07-3 2-Chloroethanol OCCCl positive positive in Vitro Mammalian Chromosome Aberration Test Tennant R.W. et al. Year 1987 Science, 236, 933-941 5634-39-9 iodinated glycerol CC(I)C1OCC(CO)O1 positive positive in Vitro Mammalian Chromosome Aberration Test NTP technical report on the toxicology and carcinogenesis studies of iodinated glycerol (CAS 5634-39-9) in F344/N rats and B6C3F1 mice. John Edgar French, NTP TR 340, March, 1990 58-89-9 Lindane ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 156-59-2 cis-1,2-Dichloroethylene Cl/C=C\Cl negative negative in Vitro Mammalian Chromosome Aberration Test Sofuni, T., Ed. (1998). Data Book of Chromosomal Aberration Test in vitro, Revised Edition. Life-Science Information Center, Tokyo, Japan 760-23-6 3,4-Dichloro-1-butene C=CC(Cl)CCl positive positive in Vitro Mammalian Chromosome Aberration Test NIHS Japan 79-34-5 1,1,2,2-Tetrachloroethane ClC(Cl)C(Cl)Cl negative negative in Vitro Mammalian Chromosome Aberration Test NTP Technical Report on the Toxicity Studies of 1,1,2,2-Tetrachloroethane (CAS No. 79-34-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice, March 2004; https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox049.pdf